Conditions, Biomarker Targets & Longevity Protocols (14)
ICD-10-mapped pathophysiology, optimal lab ranges, and direct cash-pay treatment comparison tables.
Atherogenic Dyslipidemia & Elevated ApoB
Excess circulating apolipoprotein B-containing lipoproteins (LDL, VLDL remnants, Lp(a)) driving subendothelial arterial retention and atherosclerotic plaque progression.
Essential Hypertension & Endothelial Stiffness
Sustained systemic arterial blood pressure elevation increasing left ventricular afterload, cerebral microvascular shear, and glomerular barotrauma.
Acne Vulgaris & Extrinsic Cutaneous Photoaging
Pilosebaceous follicular hyperkeratinization and Cutibacterium acnes inflammation alongside UV-induced dermal collagenase upregulation and epidermal dysplasia.
Androgenetic Alopecia & Follicular Miniaturization
Dihydrotestosterone-mediated progressive miniaturization of terminal scalp hair follicles across frontotemporal and vertex distributions in genetically susceptible men and women.
Male Hypogonadism & Androgen Deficiency
Biochemically confirmed low morning serum total and free testosterone accompanied by somatic, sexual, hematologic, and neurocognitive symptoms.
Perimenopause & Vasomotor Estrogen Deficiency
Ovarian follicular depletion producing erratic and declining 17-beta-estradiol and progesterone levels, triggering vasomotor instability, sleep fragmentation, urogenital atrophy, and accelerated trabecular bone loss.
Primary Hypothyroidism & Peripheral T4-to-T3 Deficit
Insufficient thyroid hormone receptor activation across metabolic tissues resulting from autoimmune Hashimoto thyroiditis or impaired deiodinase conversion.
Vasculogenic Erectile Dysfunction & Lower Urinary Tract BPH
Impaired cavernosal smooth-muscle nitric oxide/cGMP relaxation frequently co-occurring with prostatic stromal hyperplasia and bladder outlet obstruction.
Cellular Longevity & mTOR/AMPK Optimization
Preventive geroscience protocols targeting nutrient-sensing pathways, autophagic proteostasis, mitochondrial biogenesis, and inflammaging suppression.
Chronic Neuroinflammation & Central Sensitization
Microglial Toll-like receptor 4 hyperactivation and blunted endogenous opioid tone driving fibromyalgia, autoimmune fatigue, and central pain amplification.
Chronic Sleep-Maintenance Insomnia & Circadian Drift
Persistent difficulty initiating or maintaining restorative slow-wave and REM sleep architecture >= 3 nights weekly for over 3 months.
Major Depressive & Generalized Anxiety Disorders
Persistent affective anhedonia, autonomic hyperarousal, and cognitive executive slowing mediated by monoaminergic, HPA-axis, and neuroplastic circuit dysregulation.
Metabolic Syndrome & Visceral Adiposity
Cluster of central visceral adiposity, fasting hyperinsulinemia, elevated triglycerides, depressed HDL-C, and systemic vascular hypertension driving cardiometabolic morbidity.
Type 2 Diabetes & Insulin Resistance
Progressive skeletal muscle and hepatic insulin resistance paired with pancreatic beta-cell secretory exhaustion requiring multi-pathway glycemic and cardiorenal protection.