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Anxiety, OCD & Trauma Disorders • ICD-10-CM F40.00

Agoraphobia

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F40.00 • 5 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
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Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Agoraphobia Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Agoraphobia?

For patients presenting with Agoraphobia (ICD-10-CM F40.00), Anxiety, OCD & Trauma Disorders protocols prioritize cognitive-behavioral exposure readiness in Agoraphobia (F40.00: evaluation) paired with baseline and interval GAD-7 Anxiety Severity in Agoraphobia (F40.00: Score) assessment.

Pathophysiology, Underlying Causes & Clinical Presentation

Pathophysiologically, Agoraphobia (ICD-10 F40.00) is driven by amygdala threat-circuit hyperreactivity [Agoraphobia F40.00]; specialists in Anxiety, OCD & Trauma Disorders monitor Resting Heart Rate in Agoraphobia (F40.00: Variability (HRV)) to gauge tissue recovery.

Common Symptoms & Clinical Signs

  • • Presentation of Agoraphobia (F40.00): excessive, hard-to-control anticipatory in Agoraphobia (F40.00: worry or intrusive)
  • • Secondary Agoraphobia clinical sign: sudden autonomic surges in Agoraphobia (F40.00: with racing heart,)
  • • Symptom flares in Agoraphobia correlating with GAD-7 Anxiety Severity in Agoraphobia (F40.00: Score) deviation outside < 4 (minimal anxiety) (F40.00)
  • • Functional anxiety & ptsd impact requiring cognitive-behavioral exposure readiness in Agoraphobia (F40.00: evaluation) evaluation (F40.00)

Agoraphobia Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F40.00 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Anxiety, OCD & Trauma Disorders NLM Clinical Tables
Diagnostic / Lab Marker: GAD-7 Anxiety Severity in Agoraphobia (F40.00: Score) < 4 (minimal anxiety) (F40.00) Clinical Reference Target Range
Diagnostic / Lab Marker: Resting Heart Rate in Agoraphobia (F40.00: Variability (HRV)) Stable upward personal trend (F40.00) Clinical Reference Target Range
Diagnostic / Lab Marker: TSH & Ferritin in Agoraphobia (F40.00: Rule-Out) TSH 0.8–2.5 mIU/L; Ferritin > 50 ng/mL (F40.00) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Agoraphobia

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Treatment selection for Agoraphobia depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Agoraphobia)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Cognitive behavioral therapy, sertraline, or a combination in childhood: What a 488-Participant Study Found

Both cognitive behavioral therapy and sertraline reduced the severity of anxiety in children with anxiety; a combination of the two therapies had a superior response rate.

The New England journal of medicine • 2008-12-25 • Randomized Controlled Trial
N = 488 93/100 PMID 18974308 ↗
What the Latest Evidence Really Says About Drug treatment for panic disorder with or without agoraphobia: systematic review

The findings suggest that SSRIs provide high rates of full symptom relief with low risk of side effects for the treatment of panic disorder.

BMJ (Clinical research ed.) • 2022-01-19 • Meta-Analysis
Multi-cohort 92/100 PMID 35045991 ↗
Can This Approach Help? Inside the Latest Research on Instructed increase in fear activation during exposure exercises does not enhance

At the follow-up assessment, both treatment variants were equally effective in all outcomes.

Behaviour research and therapy • 2026-02-15 • Phase III Randomized Trial
N = 124 82/100 PMID 41539132 ↗
Zero-PHI Patient Support & Cohort Discussions

Agoraphobia Patient Community & “People Like Me” Threads

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