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Heart & Cardiovascular Disease • ICD-10-CM I42.81

Arrhythmogenic cardiomyopathy

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM I42.81 • 4 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Arrhythmogenic cardiomyopathy Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Arrhythmogenic cardiomyopathy?

Clinical triage of Arrhythmogenic cardiomyopathy (I42.81) in Heart & Vascular relies on transthoracic echocardiography [Arrhythmogenic cardiomyopathy I42.81], guiding step-wise therapeutic adjustments toward Apolipoprotein B (ApoB) [Arrhythmogenic cardiomyopathy I42.81] (< 70 mg/dL (I42.81)).

Pathophysiology, Underlying Causes & Clinical Presentation

In Arrhythmogenic cardiomyopathy (I42.81), physiological disruption stems from fibrotic extracellular matrix in Arrhythmogenic cardiomyopathy (I42.81: deposition), informing Heart & Cardiovascular Disease protocols that track Apolipoprotein B (ApoB) [Arrhythmogenic cardiomyopathy I42.81] (< 70 mg/dL (I42.81)).

Common Symptoms & Clinical Signs

  • • Presentation of Arrhythmogenic cardiomyopathy (I42.81): reduced exercise tolerance in Arrhythmogenic cardiomyopathy (I42.81: and premature cardiovascular)
  • • Secondary Arrhythmogenic cardiomyopathy clinical sign: exertional chest pressure in Arrhythmogenic cardiomyopathy (I42.81: or retrosternal tightness)
  • • Symptom flares in Arrhythmogenic cardiomyopathy correlating with High-Sensitivity Troponin I [Arrhythmogenic cardiomyopathy I42.81] deviation outside < 14 ng/L (I42.81)
  • • Functional heart & vascular impact requiring transthoracic echocardiography [Arrhythmogenic cardiomyopathy I42.81] evaluation (I42.81)

Arrhythmogenic cardiomyopathy Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code I42.81 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Heart & Cardiovascular Disease NLM Clinical Tables
Diagnostic / Lab Marker: High-Sensitivity Troponin I [Arrhythmogenic cardiomyopathy I42.81] < 14 ng/L (I42.81) Clinical Reference Target Range
Diagnostic / Lab Marker: Apolipoprotein B (ApoB) [Arrhythmogenic cardiomyopathy I42.81] < 70 mg/dL (I42.81) Clinical Reference Target Range
Diagnostic / Lab Marker: Left Ventricular Ejection in Arrhythmogenic cardiomyopathy (I42.81: Fraction (LVEF)) 55% – 70% (I42.81) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Arrhythmogenic cardiomyopathy

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Treatment selection for Arrhythmogenic cardiomyopathy depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Arrhythmogenic cardiomyopathy)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Liraglutide on heart and blood vessel Outcomes in Patients With Diabetes With or: What a 835-Participant Study Found

Based on these findings, liraglutide should be considered suitable for patients with T2D with or without a history of NYHA functional class I to III HF.

Journal of the American College of Cardiology • 2020-03-17 • Randomized Controlled Trial
N = 835 93/100 PMID 32164886 ↗
Can This Approach Help? Inside the Latest Research on Water- and Lipid-Soluble Statins on Nonculprit Lesions in Patients with Acute

IB-IVUS revealed a significant reduction in fibrous volume from 33.8 ± 20.0 to 27.5 ± 14.9 mm 3 (P 3 (P < 0.05), respectively; however, significant changes were not noted in the volume of the lipid pool for the atorvastatin...

International heart journal • 2018-01-27 • Randomized Controlled Trial
Multi-cohort 82/100 PMID 29279527 ↗
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