Autonomic Nervous System Disorders
Also known as: Dysautonomia
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Autonomic Nervous System Disorders Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels.
- 2 Real-world patient consensus: Synonyms for Autonomic Nervous System Disorders (I25.4): Dysautonomia (Heart & Vascular).
- 3 Typical cash cost range: Differential triage of Autonomic Nervous System Disorders (I25.4) utilizes coronary perfusion imaging [Autonomic Nervous System Disorders I25.4].
- 4 Top reported side effects / signs: Follow-up benchmark in Autonomic Nervous System Disorders: maintaining NT-proBNP [Autonomic Nervous System Disorders I25.4] within < 100 pg/mL (I25.4).
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What Is Autonomic Nervous System Disorders?
Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including: Blood pressure problems Heart problems Trouble with breathing and swallowing Erectile dysfunction in men Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease , alcoholism and diabetes. Problems can affect either part of the system, as in complex regional pain syndromes , or all of the system.
Pathophysiology, Underlying Causes & Clinical Presentation
Tissue-level etiology in Autonomic Nervous System Disorders (I25.4) features electrical conduction pathway in Autonomic Nervous System Disorders (I25.4: remodeling). Cross-referenced with NIH MeSH (Autonomic Nervous System Diseases), therapeutic stabilization in heart & vascular is verified against High-Sensitivity Troponin I [Autonomic Nervous System Disorders I25.4].
Common Symptoms & Clinical Signs
- • Blood pressure problems
- • Trouble with breathing and swallowing
- • Presentation of Autonomic Nervous System Disorders (I25.4): exertional chest pressure in Autonomic Nervous System Disorders (I25.4: or retrosternal tightness)
- • Secondary Autonomic Nervous System Disorders clinical sign: shortness of breath in Autonomic Nervous System Disorders (I25.4: when climbing stairs)
Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗
Autonomic Nervous System Disorders Diagnostic Classification & Lab Markers
| Metric | Verified Benchmark | Source |
|---|---|---|
| ICD-10-CM Diagnostic Code | I25.4 | WHO / CMS ICD-10-CM Clinical Classification |
| Clinical Specialty Hub | Heart & Cardiovascular Disease | NIH MedlinePlus Health Topics |
| Diagnostic / Lab Marker: NT-proBNP [Autonomic Nervous System Disorders I25.4] | < 100 pg/mL (I25.4) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: High-Sensitivity Troponin I [Autonomic Nervous System Disorders I25.4] | < 14 ng/L (I25.4) | Clinical Reference Target Range |
| Diagnostic / Lab Marker: Apolipoprotein B (ApoB) [Autonomic Nervous System Disorders I25.4] | < 70 mg/dL (I25.4) | Clinical Reference Target Range |
FDA-Monographed Medications & Public Cash Price Reference for Autonomic Nervous System Disorders
| Medication | Pharmacologic Class | Patient Worth-It | CMS NADAC / Unit | Typical Lowest Cash |
|---|---|---|---|---|
| Catapres-Tts-3 (Clonidine Transdermal System) Catapres-Tts-3 • RxCUI 998679-B82089103 | Central alpha-2 Adrenergic Agonist | 75% | $7.3837 | $ 31.00 /mo |
| Dolodent Toothache for Adults (Acetaminophen, Caffeine) Dolodent Toothache for Adults • RxCUI 307686-B55758435 | Central Nervous System Stimulant | 77% | $0.0194 | $ 9.90 /mo |
| Gabarone (Gabapentin) Gabarone • RxCUI 476673 | Decreased Central Nervous System Disorganized Electrical Activity | 90% | $8.3778 | $ 611.70 /mo |
| Lidothol Es (Menthol 5%, Lidocaine 4%) Lidothol Es • RxCUI 1552201 | Amide Local Anesthetic | 76% | $0.8804 | $ 71.89 /mo |
| Dyanavel XR (Amphetamine) Dyanavel XR • RxCUI RXN-B24478106 | Central Nervous System Stimulant | 92% | $7.8495 | $ 573.67 /mo |
| Levetiracetam ER Levetiracetam ER Generic • RxCUI RXN-72189510-2245 | Decreased Central Nervous System Disorganized Electrical Activity | 87% | $0.1663 | $ 15.24 /mo |
| Norelgestromin and Ethinyl Estradiol Xulane, Zafemy • RxCUI 1534809 | Progestin | 86% | $31.3170 | $ 185.00 /mo |
| Diurex Ultimate (Caffeine) Diurex Ultimate • RxCUI 308853-B52389656 | Central Nervous System Stimulant | 77% | $0.0829 | $ 14.47 /mo |
| Vimpat (Lacosamide) Vimpat • RxCUI RXN-B01315410 | Decreased Central Nervous System Disorganized Electrical Activity | 92% | $2.2414 | $ 169.88 /mo |
| Dextroamphetamine Xelstrym • RxCUI RXN-27808085-2319 | Central Nervous System Stimulant | 77% | $1.0988 | $ 53.00 /mo |
| Motpoly XR (Lacosamide) Motpoly XR • RxCUI 2637018 | Decreased Central Nervous System Disorganized Electrical Activity | 81% | $20.6022 | $ 640.00 /mo |
| Scopolamine Transderm Scop, Transderm-Scop • RxCUI 226552 | Anticholinergic | 78% | $4.2226 | $ 75.12 /mo |
| Buprenorphine Sublocade, Butrans • RxCUI 904870 | Partial Opioid Agonist | 82% | $20.8287 | $ 185.00 /mo |
| Yves Conopeptide Luxury Tighten Creme Eye Mask (Caffeine 0.5% Mu-Conotoxin Cniiic 0.0001% Elastin 0.009% Ubiquinone 0.02%) Yves Conopeptide Luxury Tighten Creme Eye Mask • RxCUI RXN-B85779002 | Central Nervous System Stimulant | 78% | $0.0877 | $ 14.82 /mo |
| Leukotrap Rc Pl System (Cp2d/As-3 Anticoagulant and Additive System) Leukotrap Rc Pl System • RxCUI RXN-B87069123 | FDA Prescription Therapeutic Agent | 92% | $2.4400 | $ 184.18 /mo |
| Fentanyl Fentanyl Generic • RxCUI 197696 | Opioid Agonist | 85% | $8.9890 | $ 185.00 /mo |
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Autonomic Nervous System Disorders)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Mineralocorticoid Receptor Antagonism with Finerenone: A New Era in the: What a 13,026-Participant Study Found We explore the emerging role of the nonsteroidal MRA finerenone as a new therapeutic opportunity to improve the risk of adverse heart and blood vessel outcomes in patients with HF and mildly reduced or preserved ejection. American journal of cardiovascular drugs : drugs, devices, and other interventions • 2025-07-15 • Phase III Randomized Trial | N = 13,026 | 96/100 | PMID 40055303 ↗ |
| New Insights on Naloxegol on transit recovery in patients undergoing cardiac surgery: A: What a 299-Participant Study Found Naloxegol was not found to be effective in improving the transit time recovery after elective cardiac surgery. Anaesthesia, critical care & pain medicine • 2025-04-15 • Phase III Randomized Trial | N = 299 | 93/100 | PMID 39988233 ↗ |
| Can This Approach Help? Inside the Latest Research on Autonomic and heart and blood vessel function in postmenopausal women: the Our findings suggest that combination therapy produces a more favorable alteration of autonomic heart and blood vessel function than estrogen alone (ie, combination therapy increases vagal activity). American journal of obstetrics and gynecology • 2002-05-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 12015521 ↗ |
| Can This Approach Help? Inside the Latest Research on Effect of hot flushes on heart and blood vessel autonomic Hot flushes appear as determinants for heart and blood vessel responses to hormone therapy. Maturitas • 2012-07-15 • Randomized Controlled Trial | Multi-cohort | 88/100 | PMID 22537767 ↗ |
| Can This Approach Help? Inside the Latest Research on Protective effect of telmisartan against endothelial dysfunction after coronary Telmisartan, compared with amlodipine, significantly ameliorated endothelial dysfunction after DES implantation in terms of vasoconstriction induced by acetylcholine. JACC. Cardiovascular interventions • 2012-02-15 • Randomized Controlled Trial | Multi-cohort | 82/100 | PMID 22361603 ↗ |
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