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Prostate (BPH), Bladder & Urinary Tract • ICD-10-CM N40.0

Benign prostatic hyperplasia without lower urinary tract symptoms

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM N40.0 • 7 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Benign prostatic hyperplasia without lower urinary tract symptoms Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Benign prostatic hyperplasia without lower urinary tract symptoms?

Benign prostatic hyperplasia without lower urinary tract symptoms is an ICD-10-CM indexed diagnosis (N40.0) within Prostate (BPH), Bladder & Urinary Tract. Clinical evaluation centers on alpha-1 blockers [Benign prostatic hyperplasia without lower urinary tract symptoms N40.0] alongside serial Total PSA & in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: Serum Creatinine/eGFR) tracking (Age-specific PSA; eGFR > 75 mL/min (N40.0)) to guide individualized care.

Pathophysiology, Underlying Causes & Clinical Presentation

In Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0), physiological disruption stems from alpha-1A adrenergic smooth-muscle in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: tone narrowing the), informing Prostate (BPH), Bladder & Urinary Tract protocols that track IPSS Urinary Symptom in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: Score) (0 – 7 (mild symptoms) (N40.0)).

Common Symptoms & Clinical Signs

  • • Presentation of Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0): weak, hesitant, or in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: intermittent urinary stream)
  • • Secondary Benign prostatic hyperplasia without lower urinary tract symptoms clinical sign: waking two or in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: more times nightly)
  • • Symptom flares in Benign prostatic hyperplasia without lower urinary tract symptoms correlating with Total PSA & in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: Serum Creatinine/eGFR) deviation outside Age-specific PSA; eGFR > 75 mL/min (N40.0)
  • • Functional urology & prostate impact requiring alpha-1 blockers [Benign prostatic hyperplasia without lower urinary tract symptoms N40.0] evaluation (N40.0)

Benign prostatic hyperplasia without lower urinary tract symptoms Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code N40.0 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Prostate (BPH), Bladder & Urinary Tract NLM Clinical Tables
Diagnostic / Lab Marker: Total PSA & in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: Serum Creatinine/eGFR) Age-specific PSA; eGFR > 75 mL/min (N40.0) Clinical Reference Target Range
Diagnostic / Lab Marker: IPSS Urinary Symptom in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: Score) 0 – 7 (mild symptoms) (N40.0) Clinical Reference Target Range
Diagnostic / Lab Marker: Urinalysis & Post-Void in Benign prostatic hyperplasia without lower urinary tract symptoms (N40.0: Residual (PVR)) Negative leukocyte/nitrite; PVR < 50 mL (N40.0) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Benign prostatic hyperplasia without lower urinary tract symptoms

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Terazosin Hydrochloride Hytrin • RxCUI 260376 alpha-Adrenergic Blocker 78% $0.1246 $ 7.45 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Benign prostatic hyperplasia without lower urinary tract symptoms)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Baseline Total Testosterone Level on Successful Treatment of Sexual Dysfunction: What a 1,075-Participant Study Found

Low TT levels at baseline did not negatively influence response to tadalafil in men of advancing age with concomitant lower urinary tract symptoms and benign prostatic hyperplasia and erectile dysfunction.

The journal of sexual medicine • 2016-05-15 • Randomized Controlled Trial
N = 1,075 96/100 PMID 27017071 ↗
New Insights on Benefits and safety of Combination Comprising Tamsulosin and PDE5-Is, Relative to: What a 1,144-Participant Study Found

However, therapy discontinuation due to pain and AEs did not increase with increase in AEs.

American journal of men's health • 2020-01-15 • Meta-Analysis
N = 1,144 94/100 PMID 33342335 ↗
New Insights on Monotherapies and Combination Therapy of Tamsulosin and Tadalafil for Treating: What a 1,531-Participant Study Found

Tadalafil combined with tamsulosin was more effective in the treatment of male LUTS/BPH, with or without ED, on the improvement of total IPSS, QoL, and Qmax.

Urologia internationalis • 2024-01-15 • Meta-Analysis
N = 1,531 94/100 PMID 38081154 ↗
New Insights on Tadalafil on nighttime voiding (nocturia) in men with lower urinary tract: What a 752-Participant Study Found

A statistically significant improvement in nocturnal frequency was seen with tadalafil over placebo; however, the treatment difference was small and not considered clinically meaningful.

World journal of urology • 2014-10-15 • Randomized Controlled Trial
N = 752 93/100 PMID 24504761 ↗
New Insights on Heart and blood vessel risk factors and related comorbid conditions and medical: What a 746-Participant Study Found

Once-daily tadalafil 5 mg improved LUTS/BPH, regardless of severity, in men with coexisting heart and blood vessel risk factors/comorbidities, except for patients with history of > 1 drug for arterial high blood pressure.

International journal of clinical practice • 2015-12-15 • Randomized Controlled Trial
N = 746 93/100 PMID 26299520 ↗
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