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Weight Management & Metabolic Syndrome • ICD-10-CM R63.4

Body Weight

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM R63.4 • 8 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Body Weight Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Body Weight?

What is body weight? Body weight is the total mass of your body. Keeping track of your weight is one way to check for changes in your health, but it can't tell you the whole story. That's because your weight includes muscle, bone, fat, and water. Also, everyday factors can play a role in your weight, such as your: Diet Activity level Stress level Sleep habits Family history and genetics Age What factors help determine a healthy body weight? A healthy weight is more than just a number on the scale. It's about feeling good, having energy, and lowering your risk of disease. Your health care provider can help you determine a healthy body weight based on several factors.

Pathophysiology, Underlying Causes & Clinical Presentation

Biological expression of Body Weight (R63.4, Weight & Metabolism) reflects blunted endogenous GLP-1/PYY in Body Weight (R63.4: satiety hormone release). Cross-referenced with NIH MeSH (Body Weight Changes, Body Weight), longitudinal control is benchmarked via Waist-to-Height Ratio [Body Weight R63.4].

Common Symptoms & Clinical Signs

  • • Family history and genetics
  • • Underweight. Your weight is lower than it should be for your health
  • • Presentation of Body Weight (R63.4): joint load discomfort in Body Weight (R63.4: in knees, hips,)
  • • Secondary Body Weight clinical sign: daytime sluggishness or in Body Weight (R63.4: loud snoring linked)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Body Weight Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code R63.4 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Weight Management & Metabolic Syndrome NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Waist-to-Height Ratio [Body Weight R63.4] < 0.50 (R63.4) Clinical Reference Target Range
Diagnostic / Lab Marker: HOMA-IR Insulin Resistance in Body Weight (R63.4: Index) < 1.4 (R63.4) Clinical Reference Target Range
Diagnostic / Lab Marker: ALT & Fasting in Body Weight (R63.4: Triglycerides) ALT < 25 U/L; TG < 100 mg/dL (R63.4) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Body Weight

Check Drug Interactions →
Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Phentermine Hydrochloride Lomaira, Phentermine HCl • RxCUI 803353 Sympathomimetic Amine Anorectic 89% $0.0848 $ 11.93 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Body Weight)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Potent incretin-based therapy for: What a 5,140-Participant Study Found

The side effects related to semaglutide and tirzepatide were primarily of mild-to-moderate severity and mostly gastrointestinal, which was more frequent during the dose-titration period and leveled off during the treatment period.

Obesity reviews : an official journal of the International Association for the Study of Obesity • 2024-05-15 • Meta-Analysis
N = 5,140 99/100 PMID 38463003 ↗
New Insights on Tirzepatide as a novel effective and safe strategy for treating: What a 11,758-Participant Study Found

Tirzepatide, as a weight loss drug, significantly reduces BMI, waist circumference and body weight while gastrointestinal adverse reactions need to be vigilant.

Frontiers in public health • 2024-01-15 • Meta-Analysis
N = 11,758 99/100 PMID 38356942 ↗
New Insights on Evaluation and comparison of real-world benefits and safety of tirzepatide and: What a 34,166-Participant Study Found

Both Tir and Sem demonstrated favorable antidiabetic effects and were particularly suitable for T2DM patients who were obese or overweight.

Pharmacological research • 2024-01-15 • Meta-Analysis
N = 34,166 99/100 PMID 38061595 ↗
New Insights on Benefits and safety of ipragliflozin as add-on to metformin for type 2: What a 847-Participant Study Found

Results : Five RCTs with 847 patients were included.

Postgraduate medicine • 2019-11-15 • Meta-Analysis
N = 847 97/100 PMID 31414934 ↗
New Insights on Glucagon-like peptide-1 receptor agonists for weight management in mental: What a 595-Participant Study Found

S-SEM(QW) may be the preferred treatment option, given its largest estimated effects versus control on body weight; however, its comparative ranking is uncertain due to sparse networks, substantial.

Translational psychiatry • 2026-07-08 • Meta-Analysis
N = 595 97/100 PMID 42420255 ↗
Zero-PHI Patient Support & Cohort Discussions

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