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High Blood Pressure & Vascular Health • ICD-10-CM I73.9

Claudication

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM I73.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Claudication Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Claudication?

Under High Blood Pressure & Vascular Health diagnostic criteria (I73.9), workup for Claudication integrates 24-hour ambulatory blood in Claudication (I73.9: pressure monitoring) with evidence-graded therapy tailored to Serum Creatinine & in Claudication (I73.9: Potassium) response.

Pathophysiology, Underlying Causes & Clinical Presentation

Biological expression of Claudication (I73.9, Blood Pressure) reflects venous valve incompetence [Claudication I73.9]. longitudinal control is benchmarked via Serum Creatinine & in Claudication (I73.9: Potassium).

Common Symptoms & Clinical Signs

  • • Presentation of Claudication (I73.9): morning occipital headache, in Claudication (I73.9: pulsatile tinnitus, or)
  • • Secondary Claudication clinical sign: calf cramping or in Claudication (I73.9: claudication triggered by)
  • • Symptom flares in Claudication correlating with Serum Creatinine & in Claudication (I73.9: Potassium) deviation outside K+ 4.0 – 4.8 mEq/L (I73.9)
  • • Functional blood pressure impact requiring 24-hour ambulatory blood in Claudication (I73.9: pressure monitoring) evaluation (I73.9)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Claudication Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code I73.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub High Blood Pressure & Vascular Health NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Serum Creatinine & in Claudication (I73.9: Potassium) K+ 4.0 – 4.8 mEq/L (I73.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Urine Albumin-to-Creatinine Ratio [Claudication I73.9] < 15 mg/g (I73.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Home Seated Blood in Claudication (I73.9: Pressure) < 120/75 mmHg (I73.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Claudication

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Pentoxifylline Trental • RxCUI 312301 Blood Viscosity Reducer 82% $0.2250 $ 17.61 /mo
Cilostazol Pletal • RxCUI 242461 Phosphodiesterase 3 Inhibitor 76% $0.1250 $ 7.18 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Claudication)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Benefits and safety of Actovegin in the treatment of intermittent claudication:: What a 366-Participant Study Found

The results of this 12-week course of Actovegin demonstrated its superiority over placebo in the increase in ICD and ACD at weeks 2, 12 and 24 from the start of treatment.

International angiology : a journal of the International Union of Angiology • 2022-10-15 • Phase III Randomized Trial
N = 366 93/100 PMID 36264097 ↗
New Insights on Semaglutide and walking capacity in people with symptomatic peripheral artery: What a 396-Participant Study Found

Semaglutide increased walking distance in patients with symptomatic peripheral artery disease and type 2 diabetes.

Lancet (London, England) • 2025-05-03 • Phase III Randomized Trial
N = 396 93/100 PMID 40169145 ↗
New Insights on Clazosentan on cerebral vasospasm-related morbidity and all-cause mortality after: What a 221-Participant Study Found

Clazosentan significantly reduced the combined incidence of vasospasm-related morbidity and all-cause mortality post-aSAH with no unexpected safety findings.

Journal of neurosurgery • 2022-12-01 • Phase III Randomized Trial
N = 221 88/100 PMID 35364589 ↗
Can This Approach Help? Inside the Latest Research on Valsartan blood-pressure-lowering Long-term Use Evaluation (VALUE) trial of heart

A unique feature of VALUE is the assessment of the predictive power of this heart and blood vessel risk factor scale in a large population of treated hypertensive patients.

Blood pressure • 1998-05-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 9758088 ↗
Can This Approach Help? Inside the Latest Research on Changes in REVEAL Lite 2 risk status are associated with long-term outcomes in

REVEAL Lite 2 can monitor PAH M/M risk and facilitate treatment optimization.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation • 2024-12-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 39222737 ↗
Zero-PHI Patient Support & Cohort Discussions

Claudication Patient Community & “People Like Me” Threads

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