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High Blood Pressure & Vascular Health • ICD-10-CM I74.4

Embolism - peripheral

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM I74.4 • 8 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Embolism - peripheral Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Embolism - peripheral?

Designated in federal medical registries as I74.4, Embolism - peripheral falls under Blood Pressure management, where vascular stiffness assessment [Embolism - peripheral I74.4] establishes baseline severity and rules out diagnostic mimics.

Pathophysiology, Underlying Causes & Clinical Presentation

Biological expression of Embolism - peripheral (I74.4, Blood Pressure) reflects intimal-medial vascular remodeling [Embolism - peripheral I74.4]. longitudinal control is benchmarked via Urine Albumin-to-Creatinine Ratio [Embolism - peripheral I74.4].

Common Symptoms & Clinical Signs

  • • Presentation of Embolism - peripheral (I74.4): localized extremity swelling, in Embolism - peripheral (I74.4: warmth, or venous)
  • • Secondary Embolism - peripheral clinical sign: cold distal extremities in Embolism - peripheral (I74.4: or diminished peripheral)
  • • Symptom flares in Embolism - peripheral correlating with Urine Albumin-to-Creatinine Ratio [Embolism - peripheral I74.4] deviation outside < 15 mg/g (I74.4)
  • • Functional blood pressure impact requiring vascular stiffness assessment [Embolism - peripheral I74.4] evaluation (I74.4)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Embolism - peripheral Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code I74.4 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub High Blood Pressure & Vascular Health NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Urine Albumin-to-Creatinine Ratio [Embolism - peripheral I74.4] < 15 mg/g (I74.4) Clinical Reference Target Range
Diagnostic / Lab Marker: Home Seated Blood in Embolism - peripheral (I74.4: Pressure) < 120/75 mmHg (I74.4) Clinical Reference Target Range
Diagnostic / Lab Marker: Ankle-Brachial Index (ABI) [Embolism - peripheral I74.4] 1.00 – 1.30 (I74.4) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Embolism - peripheral

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Treatment selection for Embolism - peripheral depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Embolism - peripheral)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Risk of Venous Thromboembolism with Statins: Evidence Gathered via a Network: What a 137,940-Participant Study Found

Rosuvastatin is significantly reduces the risk of VTE when compared with a placebo, other statin subtypes, and fibrate.

Balkan medical journal • 2023-09-11 • Meta-Analysis
N = 137,940 99/100 PMID 37519020 ↗
New Insights on Safety Profile of Bremelanotide Across the Clinical Development: What a 1,247-Participant Study Found

Although not deemed clinically important, bremelanotide should be used with caution in patients at risk of heart and blood vessel disease, and blood pressure should be well controlled during treatment.

Journal of women's health (2002) • 2022-02-15 • Phase III Randomized Trial
N = 1,247 96/100 PMID 35147466 ↗
New Insights on Real-world benefits and safety of direct oral anticoagulants with low molecular: What a 28,112-Participant Study Found

DOACs reduce the risk of VTE and DVT following elective THA compared with LMWH without increasing bleeding risk, for UK-licensed agents and doses.

The bone & joint journal • 2026-11-01 • Meta-Analysis
N = 28,112 94/100 PMID 42966367 ↗
New Insights on Safety and real-world benefits of ubrogepant in participants with major heart and: What a 311-Participant Study Found

The safety and real-world benefits of ubrogepant for the acute treatment of a single migraine attack did not differ by the presence of major heart and blood vessel risk factors.

Cephalalgia : an international journal of headache • 2021-08-15 • Phase III Randomized Trial
N = 311 93/100 PMID 33874756 ↗
What the Latest Evidence Really Says About Glucagon-like peptide-1 receptor agonists on mortality and heart and blood vessel

The agents of this class appear to reduce all-cause mortality, heart and blood vessel mortality, and the incidence of heart attack at mid-term follow up.

International journal of cardiology • 2017-08-01 • Meta-Analysis
Multi-cohort 92/100 PMID 28501352 ↗
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