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Prostate (BPH), Bladder & Urinary Tract • ICD-10-CM N39.6

Enlarged Prostate (BPH)

Also known as: Benign prostatic hyperplasia

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM N39.6 • 5 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Enlarged Prostate (BPH) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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3 of 3 Free Questions Remaining

What Is Enlarged Prostate (BPH)?

What is the prostate? The prostate is a gland in the male reproductive system. It lies just below the bladder. It makes fluid that is part of semen. What is an enlarged prostate (BPH)? An enlarged prostate is when your prostate gland becomes larger than normal. It's also called benign prostatic hyperplasia or BPH for short. Benign means not cancer. And hyperplasia means too much cell growth. BPH isn't cancer and it doesn't increase your risk of getting prostate cancer . Usually, the prostate gland continues to grow during adult life. That's why BPH is the most common prostate condition in people over age 50.

Pathophysiology, Underlying Causes & Clinical Presentation

In Enlarged Prostate (BPH) (N39.6), physiological disruption stems from prostatic fibromuscular stromal in Enlarged Prostate (BPH) (N39.6: hyperplasia), Cross-referenced with NIH MeSH (Prostatic Hyperplasia), informing Prostate (BPH), Bladder & Urinary Tract protocols that track Urinalysis & Post-Void in Enlarged Prostate (BPH) (N39.6: Residual (PVR)) (Negative leukocyte/nitrite; PVR < 50 mL (N39.6)).

Common Symptoms & Clinical Signs

  • • Are age 40 or older. The chance of getting BPH increases as you get older
  • • Have family members who have had BPH
  • • Presentation of Enlarged Prostate (BPH) (N39.6): weak, hesitant, or in Enlarged Prostate (BPH) (N39.6: intermittent urinary stream)
  • • Secondary Enlarged Prostate (BPH) clinical sign: waking two or in Enlarged Prostate (BPH) (N39.6: more times nightly)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Enlarged Prostate (BPH) Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code N39.6 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Prostate (BPH), Bladder & Urinary Tract NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: IPSS Urinary Symptom in Enlarged Prostate (BPH) (N39.6: Score) 0 – 7 (mild symptoms) (N39.6) Clinical Reference Target Range
Diagnostic / Lab Marker: Urinalysis & Post-Void in Enlarged Prostate (BPH) (N39.6: Residual (PVR)) Negative leukocyte/nitrite; PVR < 50 mL (N39.6) Clinical Reference Target Range
Diagnostic / Lab Marker: Total PSA & in Enlarged Prostate (BPH) (N39.6: Serum Creatinine/eGFR) Age-specific PSA; eGFR > 75 mL/min (N39.6) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Enlarged Prostate (BPH)

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Apalutamide Erleada • RxCUI 1999581 FDA Prescription Therapeutic Agent 89% $0.2200 $ 17.41 /mo
Choline C-11 Choline C-11 Generic • RxCUI RXN-52670556-1744 Radioactive Diagnostic Agent 76% $2.1000 $ 93.55 /mo
Kit for The Preparation of Gallium Ga 68 Gozetotide Locametz • RxCUI RXN-00781224-1779 FDA Prescription Therapeutic Agent 87% $2.6700 $ 116.64 /mo
Radium Ra 223 Dichloride Xofigo • RxCUI 1424214 Radioactive alpha-Particle Emitting Therapeutic Agent 87% $2.3400 $ 103.27 /mo
Fluciclovine F-18 Axumin • RxCUI RXN-69932001-1754 Radioactive Diagnostic Agent 93% $1.7100 $ 77.75 /mo
Nilutamide Nilutamide Generic • RxCUI 311982 Androgen Receptor Inhibitor 86% $3.0700 $ 132.83 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Enlarged Prostate (BPH))

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on [Therapeutic effect of tadalafil on lower urinary tract symptoms with erectile

Daily administration of tadalafil at 5 mg can effectively improve the IPSS sub-item scores in the urinary storage symptoms and IIEF-5 scores, with a persistent effect after withdrawal similar to that of its combination with...

Zhonghua nan ke xue = National journal of andrology • 2019-06-15 • Randomized Controlled Trial
N = 126 88/100 PMID 32223086 ↗
Can This Approach Help? Inside the Latest Research on Facial Skin With Conspicuous Enlarged Pores Closely Related to Severity of Facial

Moreover, the disease control rate (complete full symptom relief/partial full symptom relief/stable disease) of the primary disease was seen in 59.1%, 70.6%, and 87.0% of patients with an enlarged pore score of 1, 2, and 3,...

The Journal of dermatology • 2025-08-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 40503645 ↗
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