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Liver, Gallbladder & Pancreatic Health • ICD-10-CM K86.81

Exocrine pancreatic insufficiency

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM K86.81 • 5 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Exocrine pancreatic insufficiency Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Exocrine pancreatic insufficiency?

Cataloged under federal diagnostic code K86.81 in Liver & Hepatology, Exocrine pancreatic insufficiency requires comprehensive hepatic panel [Exocrine pancreatic insufficiency K86.81] so specialists can calibrate treatment intensity against FIB-4 Hepatic Fibrosis in Exocrine pancreatic insufficiency (K86.81: Index) benchmarks.

Pathophysiology, Underlying Causes & Clinical Presentation

At the cellular and tissue level in liver & hepatology, Exocrine pancreatic insufficiency (K86.81) involves or premature pancreatic in Exocrine pancreatic insufficiency (K86.81: acinar zymogen activation). progression correlates with shifts in FIB-4 Hepatic Fibrosis in Exocrine pancreatic insufficiency (K86.81: Index) (< 1.30 (K86.81)).

Common Symptoms & Clinical Signs

  • • Presentation of Exocrine pancreatic insufficiency (K86.81): right upper quadrant in Exocrine pancreatic insufficiency (K86.81: fullness or sharp)
  • • Secondary Exocrine pancreatic insufficiency clinical sign: unexplained fatigue, pruritus [Exocrine pancreatic insufficiency K86.81]
  • • Symptom flares in Exocrine pancreatic insufficiency correlating with FIB-4 Hepatic Fibrosis in Exocrine pancreatic insufficiency (K86.81: Index) deviation outside < 1.30 (K86.81)
  • • Functional liver & hepatology impact requiring comprehensive hepatic panel [Exocrine pancreatic insufficiency K86.81] evaluation (K86.81)

Exocrine pancreatic insufficiency Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code K86.81 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Liver, Gallbladder & Pancreatic Health NLM Clinical Tables
Diagnostic / Lab Marker: FIB-4 Hepatic Fibrosis in Exocrine pancreatic insufficiency (K86.81: Index) < 1.30 (K86.81) Clinical Reference Target Range
Diagnostic / Lab Marker: Total Bilirubin & in Exocrine pancreatic insufficiency (K86.81: Albumin) Bilirubin 0.2–1.2 mg/dL; Albumin >= 4.0 g/dL (K86.81) Clinical Reference Target Range
Diagnostic / Lab Marker: Fasting Lipase & in Exocrine pancreatic insufficiency (K86.81: Triglycerides) Normal enzymatic baseline (K86.81) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Exocrine pancreatic insufficiency

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Pancrelipase Lipase, Pancrelipase Protease, Pancrelipase Amylase Zenpep • RxCUI 1594671 FDA Prescription Therapeutic Agent 86% $4.1778 $ 177.70 /mo
Pancrelipase Pertzye, Creon • RxCUI 1294122 FDA Prescription Therapeutic Agent 83% $2.6645 $ 116.41 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Exocrine pancreatic insufficiency)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Macronutrient intake, appetite, food preferences and exocrine pancreas function

Both GLP-1 RAs comparably affected body weight, energy and macronutrient intake.

Diabetes, obesity & metabolism • 2021-10-15 • Randomized Controlled Trial
Multi-cohort 82/100 PMID 34189834 ↗
Can This Approach Help? Inside the Latest Research on Perioperative rifaximin is not associated with enhanced functional and volumetric

Further, no significant difference was found in terms of any other endpoints of functional liver- and volume regeneration or perioperative surgical complications following the application of rifaximin versus no intervention.

Scientific reports • 2021-09-09 • Phase III Randomized Trial
N = 45 82/100 PMID 34504196 ↗
Can This Approach Help? Inside the Latest Research on Controlled trial of surgery and postoperative modified FOLFOX6 versus surgery and

There was no difference in survival found between the group of the perioperative chemotherapy plus cetuximab and that of the postoperative chemotherapy in the cohort of our study.

Langenbeck's archives of surgery • 2022-06-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 35211831 ↗
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