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Heart & Cardiovascular Disease • ICD-10-CM R01.1

Heart murmur

Also known as: Heart, Cardiac, Cardio, Myocardium

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM R01.1 • 8 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Heart murmur Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Heart murmur?

Clinical triage of Heart murmur (also termed Heart or Cardiac) (R01.1) in Heart & Vascular relies on coronary perfusion imaging [Heart murmur R01.1], guiding step-wise therapeutic adjustments toward NT-proBNP [Heart murmur R01.1] (< 100 pg/mL (R01.1)).

Pathophysiology, Underlying Causes & Clinical Presentation

In Heart murmur (R01.1), physiological disruption stems from structural ventricular wall in Heart murmur (R01.1: stress), informing Heart & Cardiovascular Disease protocols that track NT-proBNP [Heart murmur R01.1] (< 100 pg/mL (R01.1)).

Common Symptoms & Clinical Signs

  • • Presentation of Heart murmur (R01.1): reduced exercise tolerance in Heart murmur (R01.1: and premature cardiovascular)
  • • Secondary Heart murmur clinical sign: exertional chest pressure in Heart murmur (R01.1: or retrosternal tightness)
  • • Symptom flares in Heart murmur correlating with Left Ventricular Ejection in Heart murmur (R01.1: Fraction (LVEF)) deviation outside 55% – 70% (R01.1)
  • • Functional heart & vascular impact requiring coronary perfusion imaging [Heart murmur R01.1] evaluation (R01.1)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Heart murmur Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code R01.1 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Heart & Cardiovascular Disease NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Left Ventricular Ejection in Heart murmur (R01.1: Fraction (LVEF)) 55% – 70% (R01.1) Clinical Reference Target Range
Diagnostic / Lab Marker: NT-proBNP [Heart murmur R01.1] < 100 pg/mL (R01.1) Clinical Reference Target Range
Diagnostic / Lab Marker: High-Sensitivity Troponin I [Heart murmur R01.1] < 14 ng/L (R01.1) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Heart murmur

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Treatment selection for Heart murmur depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Heart murmur)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
GLP-1RA vs. Placebo: Which Works Better for Heart failure and mildly reduced or preserved ejection fraction?

GLP-1RA reduce HF exacerbations and can play a role in reducing hospitalizations, improving patient's functional status, and significantly impacting the global healthcare burden of HF.

International journal of cardiology • 2025-11-01 • Meta-Analysis
N = 4,474 99/100 PMID 40623630 ↗
New Insights on GLP-1 receptor agonists on heart and blood vessel outcomes in heart failure with: What a 4,043-Participant Study Found

GLP-1 RAs may significantly lower the combined risk of mortality and hospitalization in patients with HFpEF.

Clinical research in cardiology : official journal of the German Cardiac Society • 2026-09-15 • Meta-Analysis
N = 4,043 99/100 PMID 40637782 ↗
New Insights on Sildenafil for congenital heart diseases induced lung high blood pressure, a: What a 849-Participant Study Found

Sildenafil is a well-tolerated treatment in congenital heart diseases induced lung high blood pressure, as it has proven its efficacy not only in lowering both PAP mean and systolic but also in reducing the ventilation time,...

BMC pediatrics • 2023-07-20 • Meta-Analysis
N = 849 97/100 PMID 37474896 ↗
New Insights on Major outcomes in high-risk hypertensive patients randomized to: What a 9,048-Participant Study Found

Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive.

JAMA • 2002-12-18 • Randomized Controlled Trial
N = 9,048 96/100 PMID 12479763 ↗
New Insights on Glucose levels predict hospitalization for congestive heart failure in patients: What a 25,620-Participant Study Found

Fasting plasma glucose is an independent predictor of hospitalization for CHF in high-risk subjects.

Circulation • 2007-03-20 • Randomized Controlled Trial
N = 25,620 96/100 PMID 17339550 ↗
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