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Bacterial, Viral & Fungal Infections • ICD-10-CM A04.8

Helicobacter pylori infection

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM A04.8 • 8 Linked .gov / PubMed Citations • Governance: Dr. Priya Nair, MD, FAAD (NPI #1295730425)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Helicobacter pylori infection Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Helicobacter pylori infection?

Physicians managing Helicobacter pylori infection (A04.8; Bacterial, Viral & Fungal Infections) utilize bacterial/fungal culture with in Helicobacter pylori infection (A04.8: antimicrobial susceptibility testing) and objective Complete Blood Count in Helicobacter pylori infection (A04.8: (WBC & Differential)) targets (WBC 4.0 – 10.0 x10^3/uL (A04.8)) to prevent progression and functional morbidity.

Pathophysiology, Underlying Causes & Clinical Presentation

In Helicobacter pylori infection (A04.8), physiological disruption stems from pathogen-associated molecular pattern in Helicobacter pylori infection (A04.8: (PAMP) innate immune), informing Bacterial, Viral & Fungal Infections protocols that track C-Reactive Protein / in Helicobacter pylori infection (A04.8: Procalcitonin) (Resolution to baseline (A04.8)).

Common Symptoms & Clinical Signs

  • • Presentation of Helicobacter pylori infection (A04.8): acute fever, chills, in Helicobacter pylori infection (A04.8: malaise, and myalgias)
  • • Secondary Helicobacter pylori infection clinical sign: sore throat, productive in Helicobacter pylori infection (A04.8: cough, sinus/ear pain,)
  • • Symptom flares in Helicobacter pylori infection correlating with Complete Blood Count in Helicobacter pylori infection (A04.8: (WBC & Differential)) deviation outside WBC 4.0 – 10.0 x10^3/uL (A04.8)
  • • Functional infections & antivirals impact requiring bacterial/fungal culture with in Helicobacter pylori infection (A04.8: antimicrobial susceptibility testing) evaluation (A04.8)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Helicobacter pylori infection Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code A04.8 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Bacterial, Viral & Fungal Infections NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Complete Blood Count in Helicobacter pylori infection (A04.8: (WBC & Differential)) WBC 4.0 – 10.0 x10^3/uL (A04.8) Clinical Reference Target Range
Diagnostic / Lab Marker: C-Reactive Protein / in Helicobacter pylori infection (A04.8: Procalcitonin) Resolution to baseline (A04.8) Clinical Reference Target Range
Diagnostic / Lab Marker: Targeted PCR / in Helicobacter pylori infection (A04.8: Culture & Sensitivity) Pathogen clearance / negative test (A04.8) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Helicobacter pylori infection

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Idkit Hp One (Citric Acid Anhydrous and 13c Urea) Idkit Hp One • RxCUI RXN-B50402100 Helicobacter pylori Diagnostic 91% $1.8700 $ 143.14 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Helicobacter pylori infection)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the: What a 1,046-Participant Study Found

Both vonoprazan-based regimens were superior to proton pump inhibitor-based triple therapy in clarithromycin-resistant strains and in the overall study population.

Gastroenterology • 2022-09-15 • Phase III Randomized Trial
N = 1,046 96/100 PMID 35679950 ↗
New Insights on Vonoprazan-based quadruple therapy is non-inferior to esomeprazole-based: What a 510-Participant Study Found

Vonoprazan was found to be well-tolerated and non-inferior to esomeprazole for eradicating H.

Chinese medical journal • 2025-11-20 • Phase III Randomized Trial
N = 510 93/100 PMID 39965795 ↗
New Insights on Vonoprazan non-inferior to lansoprazole in treating duodenal ulcer and: What a 263-Participant Study Found

Vonoprazan was well tolerated and non-inferior to lansoprazole for duodenal ulcer healing and achieved H.

Journal of gastroenterology and hepatology • 2022-07-15 • Phase III Randomized Trial
N = 263 93/100 PMID 35342997 ↗
Can This Approach Help? Inside the Latest Research on Efficacy of keverprazan-based quadruple therapy for Helicobacter pylori

Keverprazan 20 mg twice daily, used as a component of bismuth quadruple therapy, provided effective H.

International journal of antimicrobial agents • 2024-11-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 39293772 ↗
Can This Approach Help? Inside the Latest Research on Sequential eradication of Helicobacter pylori as a treatment for immune

Pylori eradication rate, but also a remarkable platelet response for ITP patients.

Annals of hematology • 2022-07-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 35643952 ↗
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