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Heart & Cardiovascular Disease • ICD-10-CM I88.9

Lymph node inflammation (lymphadenitis)

Also known as: Lymphadenitis

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM I88.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Lymph node inflammation (lymphadenitis) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Lymph node inflammation (lymphadenitis)?

Under Heart & Cardiovascular Disease diagnostic criteria (I88.9), workup for Lymph node inflammation (lymphadenitis) (also termed Lymphadenitis) integrates coronary perfusion imaging [Lymph node inflammation (lymphadenitis) I88.9] with evidence-graded therapy tailored to Apolipoprotein B (ApoB) [Lymph node inflammation (lymphadenitis) I88.9] response.

Pathophysiology, Underlying Causes & Clinical Presentation

Lymph node inflammation (lymphadenitis) (I88.9) alters heart & vascular homeostasis through myocardial oxygen supply-demand in Lymph node inflammation (lymphadenitis) (I88.9: mismatch); clinical remission targets Left Ventricular Ejection in Lymph node inflammation (lymphadenitis) (I88.9: Fraction (LVEF)) within 55% – 70% (I88.9).

Common Symptoms & Clinical Signs

  • • Presentation of Lymph node inflammation (lymphadenitis) (I88.9): shortness of breath in Lymph node inflammation (lymphadenitis) (I88.9: when climbing stairs)
  • • Secondary Lymph node inflammation (lymphadenitis) clinical sign: palpitations, skipped beats, in Lymph node inflammation (lymphadenitis) (I88.9: or irregular resting)
  • • Symptom flares in Lymph node inflammation (lymphadenitis) correlating with Apolipoprotein B (ApoB) [Lymph node inflammation (lymphadenitis) I88.9] deviation outside < 70 mg/dL (I88.9)
  • • Functional heart & vascular impact requiring coronary perfusion imaging [Lymph node inflammation (lymphadenitis) I88.9] evaluation (I88.9)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Lymph node inflammation (lymphadenitis) Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code I88.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Heart & Cardiovascular Disease NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Apolipoprotein B (ApoB) [Lymph node inflammation (lymphadenitis) I88.9] < 70 mg/dL (I88.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Left Ventricular Ejection in Lymph node inflammation (lymphadenitis) (I88.9: Fraction (LVEF)) 55% – 70% (I88.9) Clinical Reference Target Range
Diagnostic / Lab Marker: NT-proBNP [Lymph node inflammation (lymphadenitis) I88.9] < 100 pg/mL (I88.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Lymph node inflammation (lymphadenitis)

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Nepafenac Ilevro, Nevanac • RxCUI 1362132 Nonsteroidal Anti-inflammatory Drug 74% $121.0253 $ 185.00 /mo
Durezol (Difluprednate) Durezol • RxCUI 804544-B66758086 Anti-Inflammation Agent 89% $42.2491 $ 20.03 /mo
Prednisolone Acetate Pred Forte, Pred Mild • RxCUI 1376336 Corticosteroid 84% $30.7132 $ 30.89 /mo
Difluprednate Durezol • RxCUI 804544 Anti-Inflammation Agent 82% $7.0479 $ 20.03 /mo
Bromfenac Sodium Bromfenac Ophthalmic Solution, Prolensa • RxCUI 1375917 Nonsteroidal Anti-inflammatory Drug 89% $11.7673 $ 23.25 /mo
Loteprednol Etabonate Lotemax Sm, Alrex • RxCUI 1312625 Corticosteroid 85% $14.2657 $ 33.75 /mo
Fluorometholone Fml, Fml Forte • RxCUI 310377 Corticosteroid 75% $11.0075 $ 185.00 /mo
Technetium Tc 99m Sulfur Colloid Kit Technetium Tc 99m Sulfur Colloid Kit Generic • RxCUI RXN-65174179-1777 FDA Prescription Therapeutic Agent 90% $1.5300 $ 70.47 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Lymph node inflammation (lymphadenitis))

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Benefits and safety of CT-P10 Versus Rituximab in Untreated Low-Tumor-Burden: What a 258-Participant Study Found

These updated data support therapeutic similarity of CT-P10 and rituximab and support the use of CT-P10 single-drug treatment for previously untreated LTBFL.

Clinical lymphoma, myeloma & leukemia • 2022-02-15 • Phase III Randomized Trial
N = 258 93/100 PMID 34686445 ↗
New Insights on Value of Ultrasound in Patients with T1-T2 Breast Cancer with No Palpable Lymph: What a 1,425-Participant Study Found

In patients with cT1-2 breast cancer included in the AMAROS trial, sentinel lymph node involvement did not differ between patients who received pre-operative staging with AUS and those who were staged with clinical examination...

Annals of surgical oncology • 2026-04-15 • Phase III Randomized Trial
N = 1,425 90/100 PMID 41392224 ↗
New Insights on Quality comparison of mediastinal lymph node dissection between video-assisted: What a 1,685-Participant Study Found

This study found no significant differences in N2 upstaging proportions between the VATS and open.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery • 2025-07-01 • Phase III Randomized Trial
N = 1,685 90/100 PMID 40578313 ↗
Can This Approach Help? Inside the Latest Research on A Phase 1/2 Study of CAT-8015 in Adult Relapsed or Refractory B-Cell Non-Hodgkin

The primary objectives of this study are to determine the maximum tolerated dose (MTD) or optimal biologic dose (OBD) and safety profile of CAT-8015 in participants with relapsed or refractory advanced B-cell NHL (diffuse large B-cell lymph

ClinicalTrials.gov Registry (NIH NLM) • 2013-03-04 • Completed Human Clinical Trial (NCT)
N = 23 89/100 PMID NCT01030536 ↗
Can This Approach Help? Inside the Latest Research on Skin-applied minoxidil in hair loss areata: no effect on the perifollicular

However, no significant differences in the extent or composition of the perifollicular infiltrates were detected at week 12 between patients receiving minoxidil and placebo, or between the week-12 and week-24 biopsies of those...

The Journal of investigative dermatology • 1992-07-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 1607678 ↗
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