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Heart & Cardiovascular Disease • ICD-10-CM I21.4

Non-ST elevation (NSTEMI) myocardial infarction

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM I21.4 • 7 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Non-ST elevation (NSTEMI) myocardial infarction Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Non-ST elevation (NSTEMI) myocardial infarction?

Non-ST elevation (NSTEMI) myocardial infarction—coded clinically as I21.4 across Heart & Vascular guidelines—combines transthoracic echocardiography [Non-ST elevation (NSTEMI) myocardial infarction I21.4] with structured follow-up of NT-proBNP [Non-ST elevation (NSTEMI) myocardial infarction I21.4] (< 100 pg/mL (I21.4)).

Pathophysiology, Underlying Causes & Clinical Presentation

Tissue-level etiology in Non-ST elevation (NSTEMI) myocardial infarction (I21.4) features structural ventricular wall in Non-ST elevation (NSTEMI) myocardial infarction (I21.4: stress). therapeutic stabilization in heart & vascular is verified against NT-proBNP [Non-ST elevation (NSTEMI) myocardial infarction I21.4].

Common Symptoms & Clinical Signs

  • • Presentation of Non-ST elevation (NSTEMI) myocardial infarction (I21.4): exertional chest pressure in Non-ST elevation (NSTEMI) myocardial infarction (I21.4: or retrosternal tightness)
  • • Secondary Non-ST elevation (NSTEMI) myocardial infarction clinical sign: shortness of breath in Non-ST elevation (NSTEMI) myocardial infarction (I21.4: when climbing stairs)
  • • Symptom flares in Non-ST elevation (NSTEMI) myocardial infarction correlating with Left Ventricular Ejection in Non-ST elevation (NSTEMI) myocardial infarction (I21.4: Fraction (LVEF)) deviation outside 55% – 70% (I21.4)
  • • Functional heart & vascular impact requiring transthoracic echocardiography [Non-ST elevation (NSTEMI) myocardial infarction I21.4] evaluation (I21.4)

Non-ST elevation (NSTEMI) myocardial infarction Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code I21.4 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Heart & Cardiovascular Disease NLM Clinical Tables
Diagnostic / Lab Marker: Left Ventricular Ejection in Non-ST elevation (NSTEMI) myocardial infarction (I21.4: Fraction (LVEF)) 55% – 70% (I21.4) Clinical Reference Target Range
Diagnostic / Lab Marker: NT-proBNP [Non-ST elevation (NSTEMI) myocardial infarction I21.4] < 100 pg/mL (I21.4) Clinical Reference Target Range
Diagnostic / Lab Marker: High-Sensitivity Troponin I [Non-ST elevation (NSTEMI) myocardial infarction I21.4] < 14 ng/L (I21.4) Clinical Reference Target Range
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FDA-Monographed Medications & Public Cash Price Reference for Non-ST elevation (NSTEMI) myocardial infarction

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Treatment selection for Non-ST elevation (NSTEMI) myocardial infarction depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Non-ST elevation (NSTEMI) myocardial infarction)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Liraglutide on no-reflow in patients with acute ST-segment elevation heart: What a 284-Participant Study Found

Liraglutide may be associated with less no-reflow in STEMI, which should be confirmed by larger-scale trials.

International journal of cardiology • 2016-04-01 • Randomized Controlled Trial
N = 284 93/100 PMID 26849684 ↗
Can This Approach Help? Inside the Latest Research on Influence of ezetimibe in addition to high-dose atorvastatin therapy on plaque

Ezetimibe in addition to atorvastatin therapy did not influence NC content, but was associated with regression of coronary atherosclerosis.

Cardiovascular revascularization medicine : including molecular interventions • 2017-03-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 27919638 ↗
Can This Approach Help? Inside the Latest Research on Reduction in the magnitude of serum potassium elevation in combination therapy

In Japanese patients with type 2 diabetes and albuminuria treated with esaxerenone, concomitant use of SGLT2 inhibitor reduced the magnitude of serum potassium elevation without any change of its blood-pressure-lowering and...

Journal of diabetes investigation • 2022-07-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 35199478 ↗
Can This Approach Help? Inside the Latest Research on Assessing the potential correlation of polymorphisms in the IL6R with relative

While it is unlikely that "cytokine storm" is the norm in severe COVID19, baseline elevations above 150 pg/ml may be associated with worst outcomes and as such may warrant treatment considerations.

Cytokine • 2021-12-15 • Phase III Randomized Trial
N = 100 88/100 PMID 34353696 ↗
Can This Approach Help? Inside the Latest Research on Different doses of atorvastatin, rosuvastatin, and simvastatin on older adults

Patients with higher doses had lower level of CK-MB, BNP, ALT, and TnI and lower occurrence of MACE after PCI.

Drug development research • 2020-08-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 32142170 ↗
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