dotMD.com
Menopause, Perimenopause & Hormone Therapy • ICD-10-CM E28.39

Other primary ovarian failure

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM E28.39 • 7 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Other primary ovarian failure Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Other primary ovarian failure

3 of 3 Free Questions Remaining

What Is Other primary ovarian failure?

Other primary ovarian failure—coded clinically as E28.39 across Menopause & HRT guidelines—combines or non-hormonal NK3-receptor in Other primary ovarian failure (E28.39: therapy) with structured follow-up of 17-Beta Estradiol & in Other primary ovarian failure (E28.39: FSH (Contextual)) (Symptom-guided physiological target (E28.39)).

Pathophysiology, Underlying Causes & Clinical Presentation

Biological expression of Other primary ovarian failure (E28.39, Menopause & HRT) reflects accelerated trabecular osteoclast in Other primary ovarian failure (E28.39: turnover). longitudinal control is benchmarked via TSH & HbA1c in Other primary ovarian failure (E28.39: Midlife Panel).

Common Symptoms & Clinical Signs

  • • Presentation of Other primary ovarian failure (E28.39): midsection body-composition shift, in Other primary ovarian failure (E28.39: joint stiffness, and)
  • • Secondary Other primary ovarian failure clinical sign: vasomotor hot flashes, in Other primary ovarian failure (E28.39: sudden facial/chest warmth,)
  • • Symptom flares in Other primary ovarian failure correlating with TSH & HbA1c in Other primary ovarian failure (E28.39: Midlife Panel) deviation outside TSH 0.8–2.5 mIU/L; HbA1c < 5.6% (E28.39)
  • • Functional menopause & hrt impact requiring or non-hormonal NK3-receptor in Other primary ovarian failure (E28.39: therapy) evaluation (E28.39)

Other primary ovarian failure Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code E28.39 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Menopause, Perimenopause & Hormone Therapy NLM Clinical Tables
Diagnostic / Lab Marker: TSH & HbA1c in Other primary ovarian failure (E28.39: Midlife Panel) TSH 0.8–2.5 mIU/L; HbA1c < 5.6% (E28.39) Clinical Reference Target Range
Diagnostic / Lab Marker: 17-Beta Estradiol & in Other primary ovarian failure (E28.39: FSH (Contextual)) Symptom-guided physiological target (E28.39) Clinical Reference Target Range
Diagnostic / Lab Marker: DEXA Bone Density in Other primary ovarian failure (E28.39: & Fasting ApoB) T-Score > -1.0; ApoB < 75 mg/dL (E28.39) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Other primary ovarian failure

Check Drug Interactions →

Treatment selection for Other primary ovarian failure depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Other primary ovarian failure)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Valsartan vs. other angiotensin II receptor blockers in the treatment of high: What a 13,110-Participant Study Found

Valsartan administered at 160 or 320 mg is more effective at lowering BP than losartan 100 mg and shows comparable efficacy to other ARBs in patients with essential high blood pressure.

International journal of clinical practice • 2009-05-15 • Meta-Analysis
N = 13,110 99/100 PMID 19392925 ↗
New Insights on Efficacy comparison of monotherapies and combination therapies for androgenetic: What a 3,133-Participant Study Found

In recent years, combination therapies are showing significant promise as potential therapies.

Dermatologic therapy • 2022-03-15 • Meta-Analysis
N = 3,133 99/100 PMID 34897933 ↗
New Insights on Combination Therapy in Androgenetic hair loss: A Network Meta-Analysis of: What a 3,012-Participant Study Found

Based on the current studies, we found that the combination of Minoxidil with spironolactone, PRPF, flutamide, and finasteride may offer better treatment outcomes for patients with androgenetic hair loss.

Aesthetic plastic surgery • 2026-07-15 • Meta-Analysis
N = 3,012 99/100 PMID 42168420 ↗
New Insights on Safety profile of telmisartan as single-drug treatment or combined with: What a 8,023-Participant Study Found

The consolidated data show that telmisartan +/- HCTZ are well tolerated in patients of all ages and have placebo-like tolerabilities.

Blood pressure. Supplement • 2008-06-15 • Randomized Controlled Trial
N = 8,023 96/100 PMID 18705533 ↗
New Insights on Endometrial safety and bleeding profile of a 17β-estradiol/progesterone oral: What a 1,835-Participant Study Found

All doses of TX-001HR provided endometrial protection and were associated with an improved bleeding profile over time; older age, further last menstrual period, or lower baseline E2 may predict amenorrhea with TX-001HR.

Menopause (New York, N.Y.) • 2020-04-15 • Phase III Randomized Trial
N = 1,835 96/100 PMID 31913228 ↗
Zero-PHI Patient Support & Cohort Discussions

Other primary ovarian failure Patient Community & “People Like Me” Threads

“People Like Me” Cohort Filter (Zero-PHI)

Filter Other primary ovarian failure community threads and patient logs by age, biological sex, dosage, and treatment duration.

No threads match this cohort filter yet. Click + Start Anonymous Discussion to ask the community about Other primary ovarian failure.

Related Conditions in Menopause, Perimenopause & Hormone Therapy