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Heart & Cardiovascular Disease • ICD-10-CM I31.39

Pericardial Disorders

Also known as: Constrict, Constrictive

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM I31.39 • 5 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Pericardial Disorders Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Pericardial Disorders?

The pericardium is a membrane, or sac, that surrounds your heart. It holds the heart in place and helps it work properly. Problems with the pericardium include: Pericarditis - an inflammation of the sac. It can be from a virus or other infection, a heart attack, heart surgery, other medical conditions, injuries, and certain medicines. Pericardial effusion - the buildup of fluid in the sac Cardiac tamponade - a serious problem in which buildup of fluid in the sac causes problems with the function of the heart Symptoms of pericardial problems include chest pain, rapid heartbeat, and difficulty breathing. Fever is a common symptom of acute pericarditis.

Pathophysiology, Underlying Causes & Clinical Presentation

Biological expression of Pericardial Disorders (I31.39, Heart & Vascular) reflects myocardial oxygen supply-demand in Pericardial Disorders (I31.39: mismatch). Cross-referenced with NIH MeSH (Pericarditis, Pericardial Effusion), longitudinal control is benchmarked via Apolipoprotein B (ApoB) [Pericardial Disorders I31.39].

Common Symptoms & Clinical Signs

  • • Pericardial effusion - the buildup of fluid in the sac
  • • Cardiac tamponade - a serious problem in which buildup of fluid in the sac causes problems with the function of the heart
  • • Presentation of Pericardial Disorders (I31.39): shortness of breath in Pericardial Disorders (I31.39: when climbing stairs)
  • • Secondary Pericardial Disorders clinical sign: palpitations, skipped beats, in Pericardial Disorders (I31.39: or irregular resting)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Pericardial Disorders Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code I31.39 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Heart & Cardiovascular Disease NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Apolipoprotein B (ApoB) [Pericardial Disorders I31.39] < 70 mg/dL (I31.39) Clinical Reference Target Range
Diagnostic / Lab Marker: Left Ventricular Ejection in Pericardial Disorders (I31.39: Fraction (LVEF)) 55% – 70% (I31.39) Clinical Reference Target Range
Diagnostic / Lab Marker: NT-proBNP [Pericardial Disorders I31.39] < 100 pg/mL (I31.39) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Pericardial Disorders

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Treatment selection for Pericardial Disorders depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Pericardial Disorders)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Association of physical activity and risk of irregular heartbeat (AFib) in heart: What a 652-Participant Study Found

Our current results suggest that a higher PA level associates with a lower risk of AF in HFpEF patients.

Nutrition, metabolism, and cardiovascular diseases : NMCD • 2021-01-04 • Phase III Randomized Trial
N = 652 87/100 PMID 33097408 ↗
Can This Approach Help? Inside the Latest Research on Ivabradine for controlling heart rate in permanent irregular heartbeat (AFib): A

Ivabradine produced a moderate rate reduction in patients with permanent irregular heartbeat (AFib).

Heart rhythm • 2023-06-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 37245897 ↗
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