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Anxiety, OCD & Trauma Disorders • ICD-10-CM F40.2

Post-Traumatic Stress Disorder

Also known as: PTSD

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM F40.2 • 8 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Post-Traumatic Stress Disorder Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Post-Traumatic Stress Disorder?

What is post-traumatic stress disorder (PTSD)? Post-traumatic stress disorder (PTSD) is a mental health disorder that some people develop after they experience or see a traumatic event. The traumatic event may be life-threatening, such as combat, a natural disaster , a car accident, or sexual assault . But sometimes the event is not necessarily a dangerous one. For example, the sudden, unexpected death of a loved one can also cause PTSD. It's normal to feel afraid during and after a traumatic situation. The fear triggers a "fight-or-flight" response. This is your body's way of helping to protect itself from possible harm.

Pathophysiology, Underlying Causes & Clinical Presentation

Biological expression of Post-Traumatic Stress Disorder (F40.2, Anxiety & PTSD) reflects autonomic vagal withdrawal [Post-Traumatic Stress Disorder F40.2]. Cross-referenced with NIH MeSH (Stress Disorders, Post-Traumatic), longitudinal control is benchmarked via TSH & Ferritin in Post-Traumatic Stress Disorder (F40.2: Rule-Out).

Common Symptoms & Clinical Signs

  • • Your sex; women are more likely to develop PTSD
  • • Having had trauma in childhood
  • • Presentation of Post-Traumatic Stress Disorder (F40.2): sudden autonomic surges in Post-Traumatic Stress Disorder (F40.2: with racing heart,)
  • • Secondary Post-Traumatic Stress Disorder clinical sign: chronic neck, jaw, in Post-Traumatic Stress Disorder (F40.2: and shoulder muscle)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Post-Traumatic Stress Disorder Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code F40.2 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Anxiety, OCD & Trauma Disorders NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: TSH & Ferritin in Post-Traumatic Stress Disorder (F40.2: Rule-Out) TSH 0.8–2.5 mIU/L; Ferritin > 50 ng/mL (F40.2) Clinical Reference Target Range
Diagnostic / Lab Marker: GAD-7 Anxiety Severity in Post-Traumatic Stress Disorder (F40.2: Score) < 4 (minimal anxiety) (F40.2) Clinical Reference Target Range
Diagnostic / Lab Marker: Resting Heart Rate in Post-Traumatic Stress Disorder (F40.2: Variability (HRV)) Stable upward personal trend (F40.2) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Post-Traumatic Stress Disorder

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Regadenoson Lexiscan • RxCUI RXN-10135803-1739 Adenosine Receptor Agonist 79% $2.4300 $ 106.92 /mo
Lexiscan (Regadenoson) Lexiscan • RxCUI RXN-B04696501 Adenosine Receptor Agonist 84% $2.6300 $ 197.86 /mo
Nh3n13 Ammonia N 13 • RxCUI RXN-13267456-1740 Radioactive Diagnostic Agent 82% $2.9400 $ 127.57 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Post-Traumatic Stress Disorder)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Postoperative Pain Treatment After Pancreatic: What a 1,468-Participant Study Found

The available evidence was insufficient to establish the superiority of any single pain-relieving strategy after major pancreatic surgery.

European journal of pain (London, England) • 2026-11-15 • Meta-Analysis
N = 1,468 99/100 PMID 42944586 ↗
New Insights on Continuum of renoprotection with losartan at all stages of type 2 diabetic: What a 1,513-Participant Study Found

In proteinuric individuals with type 2 diabetes, losartan therapy reduced ESRD and hospitalizations for heart failure and was well tolerated at all levels of kidney function.

Journal of the American Society of Nephrology : JASN • 2004-12-15 • Randomized Controlled Trial
N = 1,513 96/100 PMID 15579515 ↗
New Insights on Efficacy of ubrogepant based on prior exposure and response to triptans: A post: What a 1,799-Participant Study Found

Ubrogepant efficacy and tolerability did not differ for the acute treatment of migraine in participants classified as triptan responders, triptan-insufficient responders, and triptan-naïve based on their historical experience...

Headache • 2021-03-15 • Phase III Randomized Trial
N = 1,799 96/100 PMID 33749826 ↗
New Insights on Effect of the Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, on: What a 1,001-Participant Study Found

Esaxerenone may be an effective treatment option for nocturnal high blood pressure, especially in older patients and those with a non-dipper pattern of nocturnal BP.

American journal of hypertension • 2021-05-22 • Phase III Randomized Trial
N = 1,001 96/100 PMID 33165570 ↗
New Insights on Time spent in glycaemic control with sustained body weight reduction with: What a 6,246-Participant Study Found

In this post hoc analysis, people with T2D experienced substantially longer continuous time in glycaemic control and more sustained body weight reductions with tirzepatide versus placebo and active comparators.

Diabetes, obesity & metabolism • 2025-06-15 • Randomized Controlled Trial
N = 6,246 96/100 PMID 40083081 ↗
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Post-Traumatic Stress Disorder Patient Community & “People Like Me” Threads

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