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Back Pain, Spine & Musculoskeletal Injuries • ICD-10-CM M48.05

Spinal stenosis, thoracolumbar region

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM M48.05 • 7 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Spinal stenosis, thoracolumbar region Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Spinal stenosis, thoracolumbar region?

Spinal stenosis, thoracolumbar region—coded clinically as M48.05 across Back, Spine & Ortho guidelines—combines progressive core/posterior-chain physical in Spinal stenosis, thoracolumbar region (M48.05: therapy) with structured follow-up of 25-Hydroxy Vitamin D [Spinal stenosis, thoracolumbar region M48.05] (40 – 65 ng/mL (M48.05)).

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Spinal stenosis, thoracolumbar region (M48.05) center on chemical nerve-root compression in Spinal stenosis, thoracolumbar region (M48.05: within the neural). targeted back, spine & ortho interventions aim to normalize Oswestry / Functional in Spinal stenosis, thoracolumbar region (M48.05: Mobility Score).

Common Symptoms & Clinical Signs

  • • Presentation of Spinal stenosis, thoracolumbar region (M48.05): neurogenic leg heaviness in Spinal stenosis, thoracolumbar region (M48.05: while walking upright)
  • • Secondary Spinal stenosis, thoracolumbar region clinical sign: localized axial low-back in Spinal stenosis, thoracolumbar region (M48.05: or cervical neck)
  • • Symptom flares in Spinal stenosis, thoracolumbar region correlating with Oswestry / Functional in Spinal stenosis, thoracolumbar region (M48.05: Mobility Score) deviation outside Minimal functional limitation (M48.05)
  • • Functional back, spine & ortho impact requiring progressive core/posterior-chain physical in Spinal stenosis, thoracolumbar region (M48.05: therapy) evaluation (M48.05)

Spinal stenosis, thoracolumbar region Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code M48.05 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Back Pain, Spine & Musculoskeletal Injuries NLM Clinical Tables
Diagnostic / Lab Marker: Oswestry / Functional in Spinal stenosis, thoracolumbar region (M48.05: Mobility Score) Minimal functional limitation (M48.05) Clinical Reference Target Range
Diagnostic / Lab Marker: 25-Hydroxy Vitamin D [Spinal stenosis, thoracolumbar region M48.05] 40 – 65 ng/mL (M48.05) Clinical Reference Target Range
Diagnostic / Lab Marker: Neurologic Myotome / in Spinal stenosis, thoracolumbar region (M48.05: Reflex Exam) 5/5 symmetrical motor strength (M48.05) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Spinal stenosis, thoracolumbar region

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Treatment selection for Spinal stenosis, thoracolumbar region depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Spinal stenosis, thoracolumbar region)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Sildenafil effects on sexual and heart and blood vessel responses in women with

Findings suggest that sildenafil may partially reverse the sexual dysfunction commonly associated with SCI in women.

Urology • 2000-06-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 10840082 ↗
Calmer Recovery After Surgery: How This Sedative Steadies Breathing and Heart Rate

Dexmedetomidine as an add-on booster to oxycodone PCA produced transient blood flow and heart rate effects without differences in slow heart rate or in the measured breathing variables.

Acta anaesthesiologica Scandinavica • 2027-01-15 • Randomized Controlled Trial
N = 98 88/100 PMID 42929478 ↗
Can This Approach Help? Inside the Latest Research on Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and

Analysis of CSF collected prospectively in a large cohort of children treated for ALL demonstrated significant changes in markers of oxidative stress and neurodegeneration within three.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2025-11-03 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 40905823 ↗
New Insights on An Economic Analysis of SC24 in Canada: A Randomized Study of SBRT Compared With: What a 229-Participant Study Found

SBRT is associated with higher upfront costs than CRT.

International journal of radiation oncology, biology, physics • 2024-07-15 • Phase III Randomized Trial
N = 229 82/100 PMID 38218455 ↗
Can This Approach Help? Inside the Latest Research on Automated detection of spinal bone marrow oedema in axial spondyloarthritis:

ML software shows potential for automated MRI BMO assessment in axSpA, offering benefits such as improved consistency, reduced labour costs and minimized inter- and intra-reader variability.

Rheumatology (Oxford, England) • 2025-10-01 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 40489668 ↗
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