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Asthma, COPD & Respiratory Disease • ICD-10-CM J43.0

Unilateral pulmonary emphysema [MacLeod's syndrome]

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM J43.0 • 7 Linked .gov / PubMed Citations • Governance: Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Unilateral pulmonary emphysema [MacLeod's syndrome] Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

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What Is Unilateral pulmonary emphysema [MacLeod's syndrome]?

Recognized across U.S. clinical coding as J43.0 (Lungs & Asthma), Unilateral pulmonary emphysema [MacLeod's syndrome] is evaluated via FeNO/eosinophil Type-2 inflammation in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: phenotyping) to align day-to-day symptom relief with long-term physiological stability.

Pathophysiology, Underlying Causes & Clinical Presentation

Tissue-level etiology in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0) features alveolar elastic recoil in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: loss). therapeutic stabilization in lungs & asthma is verified against Resting Pulse Oximetry in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: (SpO2)).

Common Symptoms & Clinical Signs

  • • Presentation of Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0): chronic productive or in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: dry cough worsening)
  • • Secondary Unilateral pulmonary emphysema [MacLeod's syndrome] clinical sign: prolonged recovery from in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: viral respiratory infections)
  • • Symptom flares in Unilateral pulmonary emphysema [MacLeod's syndrome] correlating with Fractional Exhaled Nitric in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: Oxide (FeNO)) deviation outside < 25 ppb (J43.0)
  • • Functional lungs & asthma impact requiring FeNO/eosinophil Type-2 inflammation in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: phenotyping) evaluation (J43.0)

Unilateral pulmonary emphysema [MacLeod's syndrome] Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code J43.0 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Asthma, COPD & Respiratory Disease NLM Clinical Tables
Diagnostic / Lab Marker: Fractional Exhaled Nitric in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: Oxide (FeNO)) < 25 ppb (J43.0) Clinical Reference Target Range
Diagnostic / Lab Marker: Resting Pulse Oximetry in Unilateral pulmonary emphysema [MacLeod's syndrome] (J43.0: (SpO2)) 96% – 100% (J43.0) Clinical Reference Target Range
Diagnostic / Lab Marker: Blood Eosinophil Count [Unilateral pulmonary emphysema [MacLeod's syndrome] J43.0] < 150 cells/uL (phenotyping marker) (J43.0) Clinical Reference Target Range
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Treatment selection for Unilateral pulmonary emphysema [MacLeod's syndrome] depends on clinical severity, diagnostic lab results, and medical history. Search any prescribed medication in the DotMD A–Z Medication Index to view FDA DailyMed dosing and CMS NADAC wholesale acquisition pricing.

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Peer-Reviewed Human Clinical Trials & Meta-Analyses (Unilateral pulmonary emphysema [MacLeod's syndrome])

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Multivariate Cluster Analyses to Characterize Asthma Heterogeneity and: What a 2,281-Participant Study Found

Benralizumab reduced exacerbations and improved lung function, primarily in late-onset asthma clusters.

The journal of allergy and clinical immunology. In practice • 2024-10-15 • Phase III Randomized Trial
N = 2,281 96/100 PMID 38663470 ↗
New Insights on Efficacy of mometasone/indacaterol/glycopyrronium in patients with inadequately: What a 3,065-Participant Study Found

MF/IND/GLY showed improvement in lung function and reduction in asthma exacerbations over MF/IND and FLU/SAL independent of baseline eosinophil levels, indicating that eosinophil levels did not affect the efficacy of...

Respiratory medicine • 2023-10-15 • Phase III Randomized Trial
N = 3,065 90/100 PMID 37392789 ↗
Can This Approach Help? Inside the Latest Research on Viscoelastic testing to assess the effects of rapid fibrinogen concentrate

There was a strong correlation between the plasma fibrinogen level and FIBTEM MCF.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis • 2021-09-01 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 33973891 ↗
Can This Approach Help? Inside the Latest Research on Subsequent immune checkpoint inhibitor treatment on overall survival with

In the JAVELIN Lung 200 trial, avelumab showed clinical activity as second-line treatment for patients with advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) • 2021-04-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 33636453 ↗
Can This Approach Help? Inside the Latest Research on Laryngeal Reinnervation vs Type I Thyroplasty in Unilateral Vocal Fold Paralysis

The results from this study have provided us with the assurance that conducting an adequately powered randomized controlled clinical trial of laryngeal reinnervation versus type I thyroplasty for adults with UVFP in the UK is...

The Laryngoscope • 2025-09-15 • Phase III Randomized Trial
N = 12 82/100 PMID 40323143 ↗
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