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Prostate (BPH), Bladder & Urinary Tract • ICD-10-CM R35.0

Urinary frequency

Also known as: Urine, Urinary, Urinate

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM R35.0 • 8 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Urinary frequency Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Urinary frequency?

Under Prostate (BPH), Bladder & Urinary Tract diagnostic criteria (R35.0), workup for Urinary frequency (also termed Urine or Urinary) integrates IPSS symptom scoring [Urinary frequency R35.0] with evidence-graded therapy tailored to IPSS Urinary Symptom in Urinary frequency (R35.0: Score) response.

Pathophysiology, Underlying Causes & Clinical Presentation

Mechanistic hallmarks of Urinary frequency (R35.0) center on prostatic fibromuscular stromal in Urinary frequency (R35.0: hyperplasia). targeted urology & prostate interventions aim to normalize IPSS Urinary Symptom in Urinary frequency (R35.0: Score).

Common Symptoms & Clinical Signs

  • • Presentation of Urinary frequency (R35.0): weak, hesitant, or in Urinary frequency (R35.0: intermittent urinary stream)
  • • Secondary Urinary frequency clinical sign: waking two or in Urinary frequency (R35.0: more times nightly)
  • • Symptom flares in Urinary frequency correlating with IPSS Urinary Symptom in Urinary frequency (R35.0: Score) deviation outside 0 – 7 (mild symptoms) (R35.0)
  • • Functional urology & prostate impact requiring IPSS symptom scoring [Urinary frequency R35.0] evaluation (R35.0)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Urinary frequency Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code R35.0 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub Prostate (BPH), Bladder & Urinary Tract NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: IPSS Urinary Symptom in Urinary frequency (R35.0: Score) 0 – 7 (mild symptoms) (R35.0) Clinical Reference Target Range
Diagnostic / Lab Marker: Urinalysis & Post-Void in Urinary frequency (R35.0: Residual (PVR)) Negative leukocyte/nitrite; PVR < 50 mL (R35.0) Clinical Reference Target Range
Diagnostic / Lab Marker: Total PSA & in Urinary frequency (R35.0: Serum Creatinine/eGFR) Age-specific PSA; eGFR > 75 mL/min (R35.0) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Urinary frequency

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Phenazopyridine Hydrochloride Uqora Maximum Uti Pain Relief, Urinary Pain Relief • RxCUI 1094104 Over-the-Counter Clinical Monograph 92% $0.1748 $ 15.58 /mo
Flavoxate Hydrochloride Urispas • RxCUI 1095229 Cholinergic Muscarinic Antagonist 76% $0.3821 $ 15.84 /mo
Marstacimab-Hncq Hympavzi • RxCUI 2697139 FDA Prescription Therapeutic Agent 74% $0.6400 $ 34.42 /mo
Mitoxantrone Mitoxantrone Generic • RxCUI 197989 Topoisomerase Inhibitor 93% $0.3500 $ 22.68 /mo
Emicizumab Hemlibra • RxCUI 1989799 FDA Prescription Therapeutic Agent 88% $2.1400 $ 95.17 /mo
Etomidate Injection, Solution Etomidate Injection, Solution Generic • RxCUI 1654006 General Anesthetic 90% $2.7500 $ 119.88 /mo
Droxia (Hydroxyurea) Droxia • RxCUI 200342 Antimetabolite 86% $0.7291 $ 61.00 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Urinary frequency)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Testosterone Replacement Therapy on Lower Urinary Tract: What a 2,029-Participant Study Found

In this meta-analysis of 14 clinical trials of TRT for LOH, the change in IPSS was similar among men receiving TRT versus placebo, suggesting that TRT treatment does not worsen LUTS among men with LOH.

European urology • 2016-06-15 • Meta-Analysis
N = 2,029 99/100 PMID 26874809 ↗
New Insights on Urinary tract infections in patients with diabetes treated with: What a 3,152-Participant Study Found

Treatment of type 2 diabetes with once-daily dapagliflozin 5 or 10mg is accompanied by a slightly increased risk of urinary tract infection.

Journal of diabetes and its complications • 2013-01-15 • Meta-Analysis
N = 3,152 99/100 PMID 23849632 ↗
New Insights on Effect of testosterone replacement therapy on lower urinary tract: What a 2,453-Participant Study Found

The results demonstrate that TRT does not worsen LUTS regardless of the administration route.

Journal of evidence-based medicine • 2024-09-15 • Meta-Analysis
N = 2,453 99/100 PMID 39004879 ↗
New Insights on Baseline Total Testosterone Level on Successful Treatment of Sexual Dysfunction: What a 1,075-Participant Study Found

Low TT levels at baseline did not negatively influence response to tadalafil in men of advancing age with concomitant lower urinary tract symptoms and benign prostatic hyperplasia and erectile dysfunction.

The journal of sexual medicine • 2016-05-15 • Randomized Controlled Trial
N = 1,075 96/100 PMID 27017071 ↗
New Insights on Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated: What a 2,222-Participant Study Found

Sulopenem was noninferior to amoxicillin/clavulanate for the treatment of adult women with uncomplicated urinary tract infection, but was associated with more frequent mild side effects.

NEJM evidence • 2025-07-15 • Phase III Randomized Trial
N = 2,222 96/100 PMID 40552968 ↗
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