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High Blood Pressure & Vascular Health • ICD-10-CM I73.9

Vascular Diseases

Also known as: Vein, Venous, Infarction, Stroke, Hyperplasia

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-11-02 • ICD-10-CM I73.9 • 8 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Vascular Diseases Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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What Is Vascular Diseases?

What are vascular diseases? Your vascular system is your body's network of blood vessels. It includes your: Arteries, which carry oxygen-rich blood from your heart to your tissues and organs Veins, which carry the blood and waste products back to your heart Capillaries, which are tiny blood vessels that connect your small arteries to your small veins. The walls of the capillaries are thin and leaky, to allow for an exchange of materials between your tissues and blood. Vascular diseases are conditions which affect your vascular system. They are common and can be serious.

Pathophysiology, Underlying Causes & Clinical Presentation

Underlying Vascular Diseases (code I73.9) is venous valve incompetence [Vascular Diseases I73.9], Cross-referenced with NIH MeSH (Vascular Diseases), which High Blood Pressure & Vascular Health clinicians address while surveilling Home Seated Blood in Vascular Diseases (I73.9: Pressure) (< 120/75 mmHg (I73.9)).

Common Symptoms & Clinical Signs

  • • Arteries, which carry oxygen-rich blood from your heart to your tissues and organs
  • • Veins, which carry the blood and waste products back to your heart
  • • Presentation of Vascular Diseases (I73.9): calf cramping or in Vascular Diseases (I73.9: claudication triggered by)
  • • Secondary Vascular Diseases clinical sign: localized extremity swelling, in Vascular Diseases (I73.9: warmth, or venous)

Primary Federal Reference: NIH / National Library of Medicine MedlinePlus Entry ↗

Vascular Diseases Diagnostic Classification & Lab Markers

Metric Verified Benchmark Source
ICD-10-CM Diagnostic Code I73.9 WHO / CMS ICD-10-CM Clinical Classification
Clinical Specialty Hub High Blood Pressure & Vascular Health NIH MedlinePlus Health Topics
Diagnostic / Lab Marker: Home Seated Blood in Vascular Diseases (I73.9: Pressure) < 120/75 mmHg (I73.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Ankle-Brachial Index (ABI) [Vascular Diseases I73.9] 1.00 – 1.30 (I73.9) Clinical Reference Target Range
Diagnostic / Lab Marker: Serum Creatinine & in Vascular Diseases (I73.9: Potassium) K+ 4.0 – 4.8 mEq/L (I73.9) Clinical Reference Target Range
Marcus Sterling (AI Healthcare Price Auditor) & Dr. Vance

FDA-Monographed Medications & Public Cash Price Reference for Vascular Diseases

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Medication Pharmacologic Class Patient Worth-It CMS NADAC / Unit Typical Lowest Cash
Nufymco (Ranibizumab-Leyk) Nufymco • RxCUI RXN-B707102172 Vascular Endothelial Growth Factor Inhibitor 82% $0.5600 $ 48.82 /mo
Jobevne (Bevacizumab-Nwgd) Jobevne • RxCUI 2712055 Vascular Endothelial Growth Factor Inhibitor 94% $1.0200 $ 81.94 /mo
Ranibizumab Lucentis, Susvimo • RxCUI 1864423 Vascular Endothelial Growth Factor Inhibitor 75% $0.6200 $ 33.61 /mo
Bevacizumab-Vikg Lytenava • RxCUI RXN-82491025-2275 Vascular Endothelial Growth Factor Inhibitor 85% $2.9000 $ 125.95 /mo
Aflibercept Eylea, Enzeevu • RxCUI 1232154 Vascular Endothelial Growth Factor Inhibitor 91% $3.5400 $ 151.87 /mo
Zaltrap (Ziv-Aflibercept) Zaltrap • RxCUI 1723189 Vascular Endothelial Growth Factor Inhibitor 80% $2.4000 $ 181.30 /mo
Bevacizumab-Bvzr Zirabev • RxCUI RXN-00690342-2280 Vascular Endothelial Growth Factor Inhibitor 83% $1.4200 $ 66.01 /mo
Yesafili (Aflibercept-Jbvf) Yesafili • RxCUI RXN-B83257035 Vascular Endothelial Growth Factor Inhibitor 94% $2.7600 $ 207.22 /mo
Ranibizumab-Leyk Nufymco • RxCUI RXN-707102172-2427 Vascular Endothelial Growth Factor Inhibitor 91% $3.2700 $ 140.94 /mo
Pavblu (Aflibercept-Ayyh) Pavblu • RxCUI 2696260 Vascular Endothelial Growth Factor Inhibitor 77% $0.3500 $ 33.70 /mo
Lytenava (Bevacizumab-Vikg) Lytenava • RxCUI RXN-B82491025 Vascular Endothelial Growth Factor Inhibitor 87% $0.6900 $ 58.18 /mo
Susvimo (Ranibizumab) Susvimo • RxCUI RXN-B50242078 Vascular Endothelial Growth Factor Inhibitor 91% $0.6300 $ 53.86 /mo
Ramucirumab Cyramza • RxCUI RXN-00027678-2828 Vascular Endothelial Growth Factor Receptor 2 Antagonist 80% $2.1200 $ 94.36 /mo
Cyramza (Ramucirumab) Cyramza • RxCUI RXN-B00027678 Vascular Endothelial Growth Factor Receptor 2 Antagonist 86% $3.1800 $ 237.46 /mo
Faricimab Vabysmo • RxCUI 2591588 FDA Prescription Therapeutic Agent 92% $1.5200 $ 70.06 /mo
Ahzantive (Aflibercept-Mrbb) Ahzantive • RxCUI RXN-B850062908 Vascular Endothelial Growth Factor Inhibitor 87% $1.9000 $ 145.30 /mo
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Vascular Diseases)

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Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Achieved blood pressure and heart and blood vessel outcomes in high-risk: What a 8,407-Participant Study Found

Mean achieved SBP less than 120 mm Hg during treatment was associated with increased risk of heart and blood vessel outcomes except for heart attack and stroke.

Lancet (London, England) • 2017-06-03 • Meta-Analysis
N = 8,407 99/100 PMID 28390695 ↗
New Insights on Effect of Glucagon-like Peptide-1 Receptor Agonists on All-cause Mortality and: What a 21,135-Participant Study Found

GLP1RA therapy when compared to placebo reduced all-cause mortality in high heart and blood vessel risk patients with type 2 diabetes.

Current diabetes reviews • 2018-01-15 • Meta-Analysis
N = 21,135 99/100 PMID 28413990 ↗
New Insights on Heart and blood vessel outcomes of liraglutide in patients with type 2: What a 14,608-Participant Study Found

Our results suggest that liraglutide treatment decreases the risk of MACE, AMI, all-cause death and heart and blood vessel death among patients with type 2 diabetes.

Medicine • 2019-11-15 • Meta-Analysis
N = 14,608 99/100 PMID 31725627 ↗
New Insights on Effect of metformin on microvascular outcomes in patients with type 2: What a 18,181-Participant Study Found

There is no evidence of clinically significant beneficial effect of metformin therapy as compared to other glucose-lowering medications or placebo on the examined microvascular complications.

Diabetes research and clinical practice • 2022-04-15 • Meta-Analysis
N = 18,181 99/100 PMID 35247521 ↗
New Insights on Association between testosterone replacement therapy and heart and blood vessel: What a 11,502-Participant Study Found

Our analysis indicates that for patients with hypogonadism, testosterone replacement therapy does not increase the CVD risk and all-cause mortality.

Progress in cardiovascular diseases • 2024-01-15 • Meta-Analysis
N = 11,502 99/100 PMID 38589271 ↗
Zero-PHI Patient Support & Cohort Discussions

Vascular Diseases Patient Community & “People Like Me” Threads

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