Intestinal Alpha-Glucosidase & Pancreatic Alpha-Amylase Inhibitor • Rx

Acarbose

Brand Reference: Precose

Medically Reviewed by Dr. Devon Caldwell, DO, MPH (NPI #1568063758)
83.40%
Patient “Worth It”
21 verified logs
$11.80
Lowest Monthly Cash

Acarbose Clinical & Real-World Cost Fact Matrix

Metric Verified Benchmark Source
Acarbose RxNorm Concept ID 16681 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $0.1840 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $64.00 / mo CMS NADAC + U.S. Retail Markup Index
Mark Cuban Cost Plus Wholesale Price $11.80 / mo Cost Plus Drugs Wholesale Feed
Community Mean Out-of-Pocket Paid $14.50 / mo 21 Zero-PHI Verified Patient Logs
INSTANT PRESCRIPTION & CASH ROUTING

Verified Online Prescribers & Wholesale Pharmacies for Acarbose

DotMD Club Members get $29 flat-rate script renewals →
Mark Cuban Cost Plus Drugs (Wholesale Pharmacy)
Requires an existing doctor prescription. Need a script? Pair with a $29 DotMD Club TeleMed consult.
$11.80/mo
Wholesale Cash Price
View Wholesale Rx →
Ro Body & Metabolic Clinic (Online Doctor Consult + Delivery)
Asynchronous physician review included • Ships in ~2 days
$ 45.00
Consult / Starting Tier
Start Online Visit →
AgelessRx Geroprotective Telehealth (Online Doctor Consult + Delivery)
Asynchronous physician review included • Ships in ~3 days • Rx included in monthly tier
$ 65.00
All-In Monthly
Start Online Visit →
Hone Health Hormone & At-Home Biomarker Lab (Online Doctor Consult + Delivery)
Asynchronous physician review included • Ships in ~3 days
$ 65.00
Consult / Starting Tier
Start Online Visit →
Sesame Direct Cash-Pay Prescriber Network (Online Doctor Consult + Delivery)
Asynchronous physician review included • Ships in ~1 days
$ 29.00
Consult / Starting Tier
Start Online Visit →

Acarbose Clinical Pharmacology & DailyMed Monograph

RxCUI 16681 • NDC 00093-7356-01

Pseudotetrasaccharide that competitively inhibits small-intestinal brush-border alpha-glucosidases (glucoamylase, sucrase, maltase), blunting postprandial glycemic and insulinemic excursions while increasing colonic short-chain fatty acid fermentation.

Across 21 community cost disclosures for Acarbose (Precose), cash buyers routing around $64.00 retail markups capture a 82% discount ($11.80/mo benchmark vs $0.1840 NADAC acquisition).

Following administration (25 mg PO with first bite of meal TID), Acarbose achieves < 2% absorbed intact from GI lumen bioavailability and immediate intraluminal action with first bite of meal onset, governed by a ~2 hours systemic terminal half-life through degraded exclusively by intestinal bacterial amylases and digestive enzymes.

Before initiating Acarbose at 25 mg PO with first bite of meal TID, clinical safety checklists rule out inflammatory bowel disease or colonic ulceration; cirrhosis; partial intestinal obstruction. Logged tolerability patterns center on flatulence (46% of reports), abdominal borborygmi (28% of reports), soft stools (14% of reports).

Half-Life
~2 hours systemic
Bioavailability
< 2% absorbed intact from GI lumen
Metabolism & Clearance
Degraded exclusively by intestinal bacterial amylases and digestive enzymes
Clinical Onset
Immediate intraluminal action with first bite of meal

Standard Adult Titration & Dosages

25 mg PO with first bite of meal TID 50 mg PO TID 100 mg PO TID

Absolute & Relative Contraindications

  • Inflammatory bowel disease or colonic ulceration
  • Cirrhosis
  • Partial intestinal obstruction

Logged Side-Effect Incidence (21 Reports)

Flatulence 46%
Abdominal borborygmi 28%
Soft stools 14%

Acarbose Patient Dosage Logs & Out-of-Pocket Cost Ledger

Across 21 verified cash-pay logs, Acarbose achieves a 83.40% Worth-It rating with out-of-pocket spend averaging $14.50/mo versus $64.00/mo walk-in retail.

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.

Effectiveness: 5/5 • Worth It Dosage: 25 mg PO with first bite of meal TID • Paid: $10.38/mo via Cost Plus Drugs
Flatulence

Switched to Cost Plus Drugs at 25 mg PO with first bite of meal TID for Acarbose; monthly out-of-pocket dropped to $10.38 compared with $64.00 retail.

Effectiveness: 5/5 • Worth It Dosage: 50 mg PO TID • Paid: $12.04/mo via Compounding

Completed 10 weeks on Acarbose (50 mg PO TID). Zero notable side effects on steady dosing.

Effectiveness: 4/5 • Worth It Dosage: 100 mg PO TID • Paid: $13.69/mo via Cash Clinic
Soft stools

Consistent biomarker response on 100 mg PO TID Acarbose sourced via Cash Clinic ($13.69/mo cash pay without insurance prior authorization).