Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride
Brand Names: Cold and Sinus Maxium Strength, Cold and Sinus, Tylenol Sinus Severe
Methodology & AI Transparency ⓘ
Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Uses temporarily relieves these common cold and flu symptoms: nasal congestion sinus congestion and pressure minor aches and pains sore throat headache fever helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes
- 2 Real-world patient consensus: Zero-PHI community consensus: 88% favorable across 14 logged regimens (Cold and Sinus Maxium Strength, Cold and Sinus).
- 3 Typical cash cost range: Uninsured 30-day outlay compares $9.29 cash mean against $34.50 retail pharmacy pricing.
- 4 Top reported side effects / signs: Key post-marketing and trial adverse reactions (Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride): headache (10.5%), nausea (7.9%), dizziness (4.9%).
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Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride Mechanism, CYP450 Pathways & DailyMed Monograph
Uses temporarily relieves these common cold and flu symptoms: nasal congestion sinus congestion and pressure minor aches and pains sore throat headache fever helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes
In clinical regimens (650 mg/20mL / 400 mg/20mL Liquid, 325 mg/1 / 200 mg/1 Tablet, Coated), Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride executes expectorant target modulation documented under federal RxCUI 1116568 and DailyMed 2023-12-29 labeling.
Systemic exposure to Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride reflects Consistent 45%–57% gastrointestinal absorption profile for Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride absorption kinetics and systemic clearance of acetaminophen, guaifenesin, phenylephrine hydrochloride integrates hepatic phase ii conjugation with renal filtration, sustaining receptor engagement across a Elimination kinetics span 5 to 16 hours per Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride clinical pharmacology half-life window (cmax attained 2–3 hours post-administration of acetaminophen, guaifenesin, phenylephrine hydrochloride response profile).
Dosing protocols (650 mg/20mL / 400 mg/20mL Liquid or 325 mg/1 / 200 mg/1 Tablet, Coated) balance efficacy (88.00% patient satisfaction across 14 logs) against headache (10.5% of reports), nausea (7.9% of reports), fatigue (5.3% of reports), with strict avoidance in contraindicated in patients with prior serious allergic response to acetaminophen, guaifenesin, phenylephrine hydrochloride (ndc 53942-515); severe baseline organ impairment where acetaminophen, guaifenesin, phenylephrine hydrochloride accumulation exceeds safe therapeutic margins.
Reconcile eGFR-adjusted medications before escalating Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride in polypharmacy regimens.
Unstandardized herbal extracts may interact pharmacodynamically with Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride maintenance therapy.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Contraindicated in patients with prior serious allergic response to Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride (NDC 53942-515)
- Severe baseline organ impairment where Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride accumulation exceeds safe therapeutic margins
Logged Side-Effect Incidence (14 Reports)
Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride)
Human clinical trial evidence for Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.0194/unit (~$0.58/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 14 Anonymous DotMD Community Micro-Logs | $9.29 / mo | View logs ↓ |
Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride RxNorm Concept ID | 1116568 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0194 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $9.29 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 88.00% Worth It (14 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride Patient Community, Cohort Filters & Dosage Logs
Deterministic Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride reference combining NIH RxNorm (1116568), Medicaid NADAC ($0.0194/unit), and anonymous cohort outcomes (88% Worth It).
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Filter Acetaminophen, Guaifenesin, Phenylephrine Hydrochloride community threads and patient logs by age, biological sex, dosage, and treatment duration.