Acetaminophen, Phenylephrine HCl
Brand Names: Sinus and Headache, Sinus Congestion and Pain Relief Non-Drowsy, Vicks Sinex Severe, Sinus Pressure and Pain, Sinus Pressure Pain, Sinus Congestion and Pain
Methodology & AI Transparency ⓘ
Acetaminophen, Phenylephrine HCl Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Uses temporarily relieves these symptoms associated with hay fever or other respiratory allergies, and the common cold: minor aches and pains headache nasal congestion sinus congestion and pressure helps decongest sinus openings and passages promotes sinus drainage helps clear nasal passages temporarily reduces fever
- 2 Real-world patient consensus: 93% patient "Worth It" rating across 19 anonymous logs for Acetaminophen, Phenylephrine HCl (RxNorm 1046378).
- 3 Typical cash cost range: Public pharmacy ledger: $9.29 low cash benchmark vs. $34.50 chain retail average ($0.0194/unit CMS NADAC).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Acetaminophen, Phenylephrine HCl: headache (10.4%), nausea (7.3%), dizziness (5.3%).
Ask our AI Specialists anything about Acetaminophen, Phenylephrine HCl
Acetaminophen, Phenylephrine HCl Mechanism, CYP450 Pathways & DailyMed Monograph
Uses temporarily relieves these symptoms associated with hay fever or other respiratory allergies, and the common cold: minor aches and pains headache nasal congestion sinus congestion and pressure helps decongest sinus openings and passages promotes sinus drainage helps clear nasal passages temporarily reduces fever
In clinical regimens (325 mg/1 / 5 mg/1 Tablet, Film Coated, 325 mg/1 / 5 mg/1 Tablet), Acetaminophen, Phenylephrine HCl executes alpha-1 adrenergic agonist target modulation documented under federal RxCUI 1046378 and DailyMed 2026-04-09 labeling.
Pharmacokinetic profiling of Acetaminophen, Phenylephrine HCl demonstrates an elimination half-life of Terminal t½ estimated at 4–14 hrs depending on renal/hepatic reserve (Acetaminophen, Phenylephrine HCl) with F ≈ 78%–90% systemic availability after standard oral Acetaminophen, Phenylephrine HCl administration systemic bioavailability; clearance proceeds via mixed metabolic conjugation and unchanged urinary excretion across acetaminophen, phenylephrine hcl regimens, reaching clinical onset within time to peak concentration spans 1 to 4 hrs under acetaminophen, phenylephrine hcl maintenance.
Titration schedules for Acetaminophen, Phenylephrine HCl (325 mg/1 / 5 mg/1 Tablet, Film Coated → 325 mg/1 / 5 mg/1 Tablet → 325 mg/1 / 5 mg/1 Capsule, Liquid Filled → 5 mg/1 / 500 mg/1 Tablet) require excluding known hypersensitivity to acetaminophen, phenylephrine hcl or structurally related alpha-1 adrenergic agonist compounds; concomitant contra-labeled cyp/transporter therapies during active acetaminophen, phenylephrine hcl administration; real-world patient logs highlight headache (10.4% of reports), nausea (7.3% of reports), dizziness (5.3% of reports) alongside a 93.00% Worth-It consensus.
Avoid overlapping alpha-1 adrenergic agonist prescriptions alongside Acetaminophen, Phenylephrine HCl to prevent cumulative receptor toxicity.
Botanical enzyme modulators may alter oral first-pass exposure of Acetaminophen, Phenylephrine HCl; disclose all supplements.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Known hypersensitivity to Acetaminophen, Phenylephrine HCl or structurally related alpha-1 adrenergic agonist compounds
- Concomitant contra-labeled CYP/transporter therapies during active Acetaminophen, Phenylephrine HCl administration
Logged Side-Effect Incidence (19 Reports)
Acetaminophen, Phenylephrine HCl Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Acetaminophen, Phenylephrine HCl)
Human clinical trial evidence for Acetaminophen, Phenylephrine HCl is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Acetaminophen, Phenylephrine HCl Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.0194/unit (~$0.58/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 19 Anonymous DotMD Community Micro-Logs | $9.29 / mo | View logs ↓ |
Acetaminophen, Phenylephrine HCl Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Acetaminophen, Phenylephrine HCl RxNorm Concept ID | 1046378 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0194 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $9.29 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 93.00% Worth It (19 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Acetaminophen, Phenylephrine HCl Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Acetaminophen, Phenylephrine HCl integrating DailyMed SPL (2026-04-09), CMS NADAC ($0.0194/unit), and 19 Zero-PHI patient logs.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Filter Acetaminophen, Phenylephrine HCl community threads and patient logs by age, biological sex, dosage, and treatment duration.