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Histamine-2 Receptor Antagonist • Over-the-Counter (OTC)

Acid Reducer (Famotidine)

Brand Names: Acid Reducer

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-06-03 • RxNorm RxCUI 310273-B42507194 • 9 Linked .gov / PubMed Citations • Governance: Dr. Marcus Thorne, MD, FACC (NPI #1184629314)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Acid Reducer (Famotidine) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

82%
Patient “Worth It” (22)
$15.64
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Acid Reducer (Famotidine)

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Dr. Vance (AI Pharmacology & Interaction Agent)

Acid Reducer (Famotidine) Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI 310273-B42507194 • NDC 42507-194

As a proprietary histamine-2 receptor antagonist presentation registered by HyVee Inc, Acid Reducer supplies active moiety Famotidine (cross-referenced at /meds/famotidine) in 20 mg/1 Tablet, Film Coated; 20 mg/1 Tablet, Delayed Release (NDC 42507-194, 72288-629; SPL 2026-06-03). Clinical prescribing and dispensing guidelines focus on Uses ; relieves heartburn associated with acid indigestion and sour stomach ; prevents heartburn associated with acid.

The active constituent inside Acid Reducer—Famotidine—functions as a targeted histamine-2 receptor antagonist agent with class-characteristic hepatorenal disposition. While therapeutic target engagement mirrors generic Famotidine, Acid Reducer (registered by HyVee Inc, SPL 2026-06-03) specifies proprietary packaging (42507-194, 72288-629) and 20 mg/1 Tablet, Film Coated; 20 mg/1 Tablet, Delayed Release quality controls alongside a $0.0992/unit NADAC acquisition baseline.

Clinical clearance of Acid Reducer (Famotidine) (Histamine-2 Receptor Antagonist) relies on hepatic enzymatic processing and renal clearance proportional to creatinine clearance (acid reducer (famotidine)) with a Biphasic clearance with 8–15 hr terminal t½ under Acid Reducer (Famotidine) maintenance half-life; patients absorbing at Systemic oral bioavailability of roughly 60%–72% following first-pass transit bioavailability typically observe target onset around initial pharmacodynamic onset within 1–3 hrs (peak cmax) for acid reducer (famotidine).

FDA clinical labeling for Acid Reducer (Famotidine) restricts administration in documented intolerance or hypersensitivity reaction involving famotidine (histamine-2 receptor antagonist); concurrent restricted medications flagged in section 4/7 of the acid reducer (famotidine) dailymed monograph (310273-b42507194) across 20 mg/1 Tablet, Film Coated, 20 mg/1 Tablet, Delayed Release, 20 mg/1 Tablet, 10 mg/1 Tablet, Film Coated, 20 mg/1 Capsule, Delayed Release, with self-reported patient tracking dominated by nausea (8.6% of reports), headache (7.1% of reports), dizziness (6.2% of reports).

Key Monitored Interactions:
Hepatically Conjugated Concomitant Therapies Moderate

Assess baseline hepatic panels and interacting prescriptions when starting Acid Reducer (Famotidine) (histamine-2 receptor antagonist).

Gastric pH-Altering Agents (PPIs & H2 Blockers) Minor

Shifts in intragastric pH can modestly influence dissolution kinetics of oral Acid Reducer (Famotidine) dosage forms.

Half-Life
Biphasic clearance with 8–15 hr terminal t½ under Acid Reducer (Famotidine) maintenance
Bioavailability
Systemic oral bioavailability of roughly 60%–72% following first-pass transit
Metabolism & Clearance
Hepatic enzymatic processing and renal clearance proportional to creatinine clearance (Acid Reducer (Famotidine))
Clinical Onset
Initial pharmacodynamic onset within 1–3 hrs (peak Cmax) for Acid Reducer (Famotidine)

Standard Adult Titration & Dosages

20 mg/1 Tablet, Film Coated 20 mg/1 Tablet, Delayed Release 20 mg/1 Tablet 10 mg/1 Tablet, Film Coated 20 mg/1 Capsule, Delayed Release

Absolute & Relative Contraindications

  • Documented intolerance or hypersensitivity reaction involving Famotidine (histamine-2 receptor antagonist)
  • Concurrent restricted medications flagged in Section 4/7 of the Acid Reducer (Famotidine) DailyMed monograph (310273-B42507194)

Logged Side-Effect Incidence (22 Reports)

Nausea 8.6%
Headache 7.1%
Dizziness 6.2%
Dyspepsia 5.4%
Fatigue 4.9%
Diarrhea 4%
Elena Rostova (AI Biostatistician & openFDA Quant)

Acid Reducer (Famotidine) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (22)
Nausea FAERS: 8.6% • Logs: 8.6%
Fatigue FAERS: 4.9% • Logs: 4.9%
Diarrhea FAERS: 4% • Logs: 4%
Headache FAERS: 7.1% • Logs: 7.1%
Dizziness FAERS: 6.2% • Logs: 6.2%
Dyspepsia FAERS: 5.4% • Logs: 5.4%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Acid Reducer (Famotidine))

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Factors Associated With Enhanced Low-Density Lipoprotein Cholesterol Lowering: What a 2,321-Participant Study Found

Factors including statin absence, female sex, diabetes history, ezetimibe use, and a higher high-sensitivity C-reactive protein level may be useful to identify patients who may have a greater LDL-C reduction with BA.

Journal of the American Heart Association • 2022-08-02 • Phase III Randomized Trial
N = 2,321 96/100 PMID 35916348 ↗
New Insights on Long-Term safety and real-world benefits of Bempedoic Acid in Patients With: What a 1,462-Participant Study Found

Bempedoic acid was generally well tolerated and demonstrated sustained efficacy with up to 2.5 years of continuous treatment.

The American journal of cardiology • 2022-07-01 • Phase III Randomized Trial
N = 1,462 96/100 PMID 35483979 ↗
New Insights on Benefits and safety of fenofibric acid in combination with atorvastatin and: What a 543-Participant Study Found

In patients with mixed high cholesterol, the combination of FA + Atorva/Eze significantly improved lipid and nonlipid parameters compared with Atorva/Eze and was generally well tolerated.

American heart journal • 2010-10-15 • Phase III Randomized Trial
N = 543 93/100 PMID 20934572 ↗
New Insights on A single intra-articular injection of JTA-004, a combination of human plasma,: What a 746-Participant Study Found

A single IA injection of JTA-004 was not superior to a saline solution (LSmean difference: -1.50 mm, 95%CI 5.12; 2.12, p= 0.42) or Synvisc-One® (LSmean difference: 2.40, 95% CI: -1.22; 6.02, p=0.20) for the treatment of OA...

Osteoarthritis and cartilage • 2026-02-15 • Phase III Randomized Trial
N = 746 93/100 PMID 41015076 ↗
New Insights on A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal: What a 256-Participant Study Found

Selenium supplementation was associated with a significantly smaller increase in 5-HETE after 12 months compared to the placebo, though no other results were statistically significant.

Nutrients • 2021-10-29 • Phase III Randomized Trial
N = 256 93/100 PMID 34836131 ↗
Marcus Sterling (AI Healthcare Price Auditor)

Acid Reducer (Famotidine) Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI 310273-B42507194
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $0.0992/unit (~$2.98/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $41.45 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 22 Anonymous DotMD Community Micro-Logs $15.64 / mo View logs ↓

Acid Reducer (Famotidine) Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Acid Reducer (Famotidine) RxNorm Concept ID 310273-B42507194 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $0.0992 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $41.45 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $15.64 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 82.00% Worth It (22 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Acid Reducer (Famotidine) Patient Community, Cohort Filters & Dosage Logs

Deterministic Acid Reducer (Famotidine) reference combining NIH RxNorm (310273-B42507194), Medicaid NADAC ($0.0992/unit), and anonymous cohort outcomes (82% Worth It).

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.

“People Like Me” Cohort Filter (Zero-PHI)

Filter Acid Reducer (Famotidine) community threads and patient logs by age, biological sex, dosage, and treatment duration.

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