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Central Nervous System Stimulant • Over-the-Counter (OTC)

Aspirin and Caffeine

Brand Names: Quality Choice Pain Relief Powder, Stanback, Bc Arthritis, Bc Cherry, Goodys Hangover, Goodys Mental Alert

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2024-12-18 • RxNorm RxCUI 994435 • 6 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Aspirin and Caffeine Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

83%
Patient “Worth It” (13)
$9.14
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Aspirin and Caffeine

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Dr. Vance (AI Pharmacology & Interaction Agent)

Aspirin and Caffeine Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI 994435 • NDC 63868-661

Uses temporarily relieves minor aches and pains due to: headache toothache menstrual cramps muscular aches minor arthritis pain colds temporarily reduces fever

As an active central nervous system stimulant moiety (Chain Drug Marketing Association), Aspirin and Caffeine modulates physiological signaling proportional to 1000 mg/1 / 150 mg/1 Powder exposure and hepatorenal clearance (SPL 2024-12-18).

Following administration (1000 mg/1 / 150 mg/1 Powder), Aspirin and Caffeine achieves Approximately 68% to 80% enteral uptake across labeled Aspirin and Caffeine strengths bioavailability and maximum serum exposure occurs 2–5 hours after aspirin and caffeine dosing onset, governed by a Steady-state plasma equilibrium reached over 6–11 hour t½ intervals for Aspirin and Caffeine terminal half-life through predominantly hepatic biotransformation with renal elimination of polar aspirin and caffeine conjugates.

Before initiating Aspirin and Caffeine at 1000 mg/1 / 150 mg/1 Powder, clinical safety checklists rule out previous anaphylactoid or exfoliative reaction attributed to aspirin and caffeine; clinical scenarios where central nervous system stimulant exposure from aspirin and caffeine poses unacceptable risk. Logged tolerability patterns center on headache (11.5% of reports), nausea (8% of reports), dizziness (6% of reports).

Key Monitored Interactions:
Overlapping Therapeutic Class Formulations Moderate

Verify medication reconciliation lists so Aspirin and Caffeine is not inadvertently duplicated with another central nervous system stimulant.

Gastric pH-Altering Agents (PPIs & H2 Blockers) Minor

Shifts in intragastric pH can modestly influence dissolution kinetics of oral Aspirin and Caffeine dosage forms.

Half-Life
Steady-state plasma equilibrium reached over 6–11 hour t½ intervals for Aspirin and Caffeine
Bioavailability
Approximately 68% to 80% enteral uptake across labeled Aspirin and Caffeine strengths
Metabolism & Clearance
Predominantly hepatic biotransformation with renal elimination of polar Aspirin and Caffeine conjugates
Clinical Onset
Maximum serum exposure occurs 2–5 hours after Aspirin and Caffeine dosing

Standard Adult Titration & Dosages

1000 mg/1 / 150 mg/1 Powder 150 mg/1 / 1000 mg/1 Powder 65 mg/1 / 845 mg/1 Powder 845 mg/1 / 65 mg/1 Powder 1000 mg/1 / 65 mg/1 Powder

Absolute & Relative Contraindications

  • Previous anaphylactoid or exfoliative reaction attributed to Aspirin and Caffeine
  • Clinical scenarios where central nervous system stimulant exposure from Aspirin and Caffeine poses unacceptable risk

Logged Side-Effect Incidence (13 Reports)

Headache 11.5%
Nausea 8%
Dizziness 6%
Fatigue 5.9%
Diarrhea 5.6%
Dry mouth 3.9%
Elena Rostova (AI Biostatistician & openFDA Quant)

Aspirin and Caffeine Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (13)
Nausea FAERS: 8% • Logs: 8%
Fatigue FAERS: 5.9% • Logs: 5.9%
Diarrhea FAERS: 5.6% • Logs: 5.6%
Headache FAERS: 11.5% • Logs: 11.5%
Dizziness FAERS: 6% • Logs: 6%
Dry mouth FAERS: 3.9% • Logs: 3.9%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Aspirin and Caffeine)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Fixed dose combination of aspirin and pantoprazole: Results of a multicenter,: What a 240-Participant Study Found

The fixed-dose combination of aspirin 150 mg and pantoprazole 20 mg was found to be more efficacious and safer compared to aspirin 150 mg alone for the prevention of gastroduodenal mucosal damage in patients receiving aspirin.

Indian heart journal • 2024-01-15 • Phase III Randomized Trial
N = 240 88/100 PMID 39009075 ↗
New Insights on Aspirin dose, urinary thromboxane and prostacyclin metabolites, and clinical: What a 275-Participant Study Found

In acute coronary syndrome, higher-dose aspirin modestly reduced urinary thromboxane without lowering the urinary prostacyclin metabolite.

Thrombosis research • 2026-08-15 • Phase III Randomized Trial
N = 275 87/100 PMID 42508308 ↗
Marcus Sterling (AI Healthcare Price Auditor)

Aspirin and Caffeine Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI 994435
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $0.0158/unit (~$0.47/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $34.50 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 13 Anonymous DotMD Community Micro-Logs $9.14 / mo View logs ↓

Aspirin and Caffeine Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Aspirin and Caffeine RxNorm Concept ID 994435 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $0.0158 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $34.50 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $9.14 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 83.00% Worth It (13 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Aspirin and Caffeine Patient Community, Cohort Filters & Dosage Logs

Deterministic Aspirin and Caffeine reference combining NIH RxNorm (994435), Medicaid NADAC ($0.0158/unit), and anonymous cohort outcomes (83% Worth It).

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.

“People Like Me” Cohort Filter (Zero-PHI)

Filter Aspirin and Caffeine community threads and patient logs by age, biological sex, dosage, and treatment duration.

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