Atovaquone and Proguanil Hydrochloride Pediatric
Brand Names: Atovaquone and Proguanil Hydrochloride Pediatric Generic
Methodology & AI Transparency ⓘ
Atovaquone and Proguanil Hydrochloride Pediatric Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Atovaquone and proguanil hydrochloride tablets are an antimalarial indicated for: ; prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported.
- 2 Real-world patient consensus: 82% patient "Worth It" rating across 19 anonymous logs for Atovaquone and Proguanil Hydrochloride Pediatric (RxNorm 864675).
- 3 Typical cash cost range: Uninsured 30-day outlay compares $44.47 cash mean against $108.95 retail pharmacy pricing.
- 4 Top reported side effects / signs: Most commonly reported Atovaquone and Proguanil Hydrochloride Pediatric tolerability events: headache (9.6%), diarrhea (8.3%), abdominal discomfort (3.8%).
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Atovaquone and Proguanil Hydrochloride Pediatric Mechanism, CYP450 Pathways & DailyMed Monograph
Atovaquone and proguanil hydrochloride tablets are an antimalarial indicated for: ; prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. ( 1.1 ) ; treatment of acute, uncomplicated P. falciparum malaria. ( 1.2 ) 1.1 Prevention of Malaria Atovaquone and proguanil hydrochloride tablets are indicated for the prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. 1.2 Treatment of Malaria Atovaquone and proguanil hydrochloride tablets are indicated for the treatment of acute, uncomplicated P.
12.1 Mechanism of Action Atovaquone and proguanil hydrochloride tablets, fixed-dose combination of atovaquone and proguanil hydrochloride is an antimalarial agent .
Systemic exposure to Atovaquone and Proguanil Hydrochloride Pediatric reflects Systemic oral bioavailability of roughly 74%–86% following first-pass transit absorption kinetics and hepatic enzymatic processing and renal clearance proportional to creatinine clearance (atovaquone and proguanil hydrochloride pediatric), sustaining receptor engagement across a Biphasic clearance with 5–10 hr terminal t½ under Atovaquone and Proguanil Hydrochloride Pediatric maintenance half-life window (initial pharmacodynamic onset within 1–3 hrs (peak cmax) for atovaquone and proguanil hydrochloride pediatric response profile).
Dosing protocols (62.5 mg/1 / 25 mg/1 Tablet, Film Coated or Stepwise Atovaquone and Proguanil Hydrochloride Pediatric titration guided by clinical response and eGFR) balance efficacy (82.00% patient satisfaction across 19 logs) against headache (9.6% of reports), diarrhea (8.3% of reports), nausea (7.5% of reports), with strict avoidance in 4 contraindications; known serious hypersensitivity reactions to atovaquone or proguanil hydrochloride or any component of the formulation.; falciparum malaria in patients with severe renal impairment (creatinine clearance <30 ml/min)..
Co-administering Atovaquone and Proguanil Hydrochloride Pediatric with coumarin anticoagulants can shift prothrombin INR values and heighten hemorrhage risk.
Enzyme inducers accelerate biotransformation of Atovaquone and Proguanil Hydrochloride Pediatric, potentially lowering trough levels below therapeutic threshold.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- 4 CONTRAINDICATIONS
- Known serious hypersensitivity reactions to atovaquone or proguanil hydrochloride or any component of the formulation.
- falciparum malaria in patients with severe renal impairment (creatinine clearance <30 mL/min).
Logged Side-Effect Incidence (19 Reports)
Atovaquone and Proguanil Hydrochloride Pediatric Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Atovaquone and Proguanil Hydrochloride Pediatric)
Human clinical trial evidence for Atovaquone and Proguanil Hydrochloride Pediatric is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Atovaquone and Proguanil Hydrochloride Pediatric Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.8880/unit (~$26.64/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $108.95 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 19 Anonymous DotMD Community Micro-Logs | $44.47 / mo | View logs ↓ |
| Ro Body & Metabolic Clinic (Licensed Telehealth Cash Program) | State-licensed clinician review • ~2d mail fulfillment | $45.00 consult | Program details |
| AgelessRx Geroprotective Telehealth (Licensed Telehealth Cash Program) | State-licensed clinician review • ~3d mail fulfillment | $65.00/mo program | Program details |
Atovaquone and Proguanil Hydrochloride Pediatric Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Atovaquone and Proguanil Hydrochloride Pediatric RxNorm Concept ID | 864675 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.8880 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $108.95 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $44.47 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 82.00% Worth It (19 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Atovaquone and Proguanil Hydrochloride Pediatric Patient Community, Cohort Filters & Dosage Logs
Cross-verified Atovaquone and Proguanil Hydrochloride Pediatric (antimalarial) monograph synthesizing RxNorm 864675, openFDA FAERS signals, and $44.47–$108.95 cash benchmarks.
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