Brand Reference: Invokana
| Metric | Verified Benchmark | Source |
|---|---|---|
| Canagliflozin RxNorm Concept ID | 1373458 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $19.1100 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $628.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $95.00 / mo (Direct TeleMed) | Direct Telehealth Formulary |
| Community Mean Out-of-Pocket Paid | $142.00 / mo | 11 Zero-PHI Verified Patient Logs |
Blocks renal SGLT2 glucose reabsorption while transiently blunting brush-border intestinal SGLT1 at 300 mg pre-meal dosing, blunting peak postprandial glucose spikes—demonstrated in NIA Interventions Testing Program male cohorts to extend median lifespan.
CMS National Average Drug Acquisition Cost (NADAC) tracking places Canagliflozin (Invokana, RxCUI 1373458) at $19.1100 per unit, whereas walk-in chain pharmacies bill cash patients an average of $628.00 monthly—creating a 77% ($486.00/mo) wholesale arbitrage spread down to $142.00.
Systemic exposure to Canagliflozin reflects 65% oral absorption kinetics and o-glucuronidation via ugt1a9 and ugt2b4 into two inactive metabolites, sustaining receptor engagement across a 10.6–13.1 hours half-life window (1–2 hours post-dose response profile).
Dosing protocols (100 mg PO before first meal or 300 mg PO before first meal) balance efficacy (81.00% patient satisfaction across 11 logs) against polyuria (21% of reports), thirst (18% of reports), yeast irritation (10% of reports), with strict avoidance in severe renal dialysis; active lower-limb ischemic ulceration.
Across 11 verified cash-pay logs, Canagliflozin achieves a 81.00% Worth-It rating with out-of-pocket spend averaging $142.00/mo versus $628.00/mo walk-in retail.
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Switched to Local Pharmacy at 100 mg PO before first meal for Canagliflozin; monthly out-of-pocket dropped to $124.96 compared with $628.00 retail.
Completed 10 weeks on Canagliflozin (300 mg PO before first meal). Zero notable side effects on steady dosing.
Consistent biomarker response on 100 mg PO before first meal Canagliflozin sourced via Compounding ($164.72/mo cash pay without insurance prior authorization).