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Radiographic Contrast Agent • Prescription (Rx)

Carbon Dioxide

Brand Names: Carbon Dioxide Generic

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-07-01 • RxNorm RxCUI RXN-14961009-2304 • 9 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Carbon Dioxide Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

79%
Patient “Worth It” (6)
$29.97
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Carbon Dioxide

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Dr. Vance (AI Pharmacology & Interaction Agent)

Carbon Dioxide Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI RXN-14961009-2304 • NDC 14961-009

Clinicians prescribe Carbon Dioxide (990 mL/L Gas and 995 mL/L Gas; NDC 14961-009, 10736-014) as a respiratory (inhalation)-route radiographic contrast agent formulation manufactured/labeled by Haun Specialty Gases, Inc. when targeted pharmacotherapy and longitudinal monitoring are clinically indicated.

Carbon Dioxide exerts selective radiographic contrast agent pharmacodynamic activity across 990 mL/L Gas and 995 mL/L Gas (respiratory (inhalation)-route route, manufactured/labeled by Haun Specialty Gases, Inc.), coupling targeted tissue distribution with predictable systemic biotransformation (NDC 14961-009, 10736-014).

Pharmacokinetic profiling of Carbon Dioxide demonstrates an elimination half-life of Elimination kinetics span 5 to 16 hours per Carbon Dioxide clinical pharmacology with Consistent 50%–62% gastrointestinal absorption profile for Carbon Dioxide systemic bioavailability; clearance proceeds via systemic clearance of carbon dioxide integrates hepatic phase ii conjugation with renal filtration, reaching clinical onset within cmax attained 2–5 hours post-administration of carbon dioxide.

Titration schedules for Carbon Dioxide (990 mL/L Gas → 995 mL/L Gas → 1 g/g Gas → 99 L/100L Gas → 990 g/kg Gas) require excluding history of severe allergic sensitivity to carbon dioxide active moiety or formulation vehicle; acute clinical instability or interacting polypharmacy excluded under 2026-07-01 carbon dioxide labeling; real-world patient logs highlight nausea (9.2% of reports), headache (8.5% of reports), dizziness (5.8% of reports) alongside a 79.00% Worth-It consensus.

Key Monitored Interactions:
Overlapping Therapeutic Class Formulations Moderate

Verify medication reconciliation lists so Carbon Dioxide is not inadvertently duplicated with another radiographic contrast agent.

Gastric pH-Altering Agents (PPIs & H2 Blockers) Minor

Shifts in intragastric pH can modestly influence dissolution kinetics of oral Carbon Dioxide dosage forms.

Half-Life
Elimination kinetics span 5 to 16 hours per Carbon Dioxide clinical pharmacology
Bioavailability
Consistent 50%–62% gastrointestinal absorption profile for Carbon Dioxide
Metabolism & Clearance
Systemic clearance of Carbon Dioxide integrates hepatic phase II conjugation with renal filtration
Clinical Onset
Cmax attained 2–5 hours post-administration of Carbon Dioxide

Standard Adult Titration & Dosages

990 mL/L Gas 995 mL/L Gas 1 g/g Gas 99 L/100L Gas 990 g/kg Gas

Absolute & Relative Contraindications

  • History of severe allergic sensitivity to Carbon Dioxide active moiety or formulation vehicle
  • Acute clinical instability or interacting polypharmacy excluded under 2026-07-01 Carbon Dioxide labeling

Logged Side-Effect Incidence (6 Reports)

Nausea 9.2%
Headache 8.5%
Dizziness 5.8%
Diarrhea 5%
Fatigue 4.7%
Dry mouth 4.7%
Elena Rostova (AI Biostatistician & openFDA Quant)

Carbon Dioxide Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (6)
Nausea FAERS: 9.2% • Logs: 9.2%
Fatigue FAERS: 4.7% • Logs: 4.7%
Diarrhea FAERS: 5% • Logs: 5%
Headache FAERS: 8.5% • Logs: 8.5%
Dizziness FAERS: 5.8% • Logs: 5.8%
Dry mouth FAERS: 4.7% • Logs: 4.7%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Carbon Dioxide)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Veverimer on serum bicarbonate and physical function in women with chronic kidney

Veverimer was effective in treating metabolic acidosis in women with CKD, and significantly improved how they felt and functioned.

BMC nephrology • 2022-02-25 • Phase III Randomized Trial
N = 77 88/100 PMID 35216581 ↗
Can This Approach Help? Inside the Latest Research on Efficacy of carboxytherapy in hair

Carboxytherapy seems to be a promising therapeutic option for patchy AA and could be helpful as an add-on treatment of AGA but more than 6 sessions are required and adjuvants are recommended for maintenance of the results.

Journal of cosmetic dermatology • 2018-12-15 • Randomized Controlled Trial
N = 80 88/100 PMID 29460509 ↗
Can This Approach Help? Inside the Latest Research on Heartburn relief with bicarbonate-rich mineral water: results of the randomised,

STOMACH STILL is the first controlled clinical trial demonstrating superiority of a mineral water over placebo in relieving heartburn, accompanied by an improved HRQOL.

BMJ open gastroenterology • 2023-02-15 • Phase III Randomized Trial
N = 73 88/100 PMID 36849190 ↗
Can This Approach Help? Inside the Latest Research on Veverimer on serum bicarbonate and physical function in diabetic patients with

Few interventions for patients with diabetes and CKD have successfully improved quality of life or physical functioning.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2022-06-23 • Phase III Randomized Trial
N = 70 88/100 PMID 34240198 ↗
Can This Approach Help? Inside the Latest Research on Hormone replacement therapy on cerebral serotonin-1A receptor binding in

Although we were not able to confirm effects of gonadal hormone treatment on 5-HT₁A receptor binding, our data do not preclude associations between sex steroid levels and serotonin, the neurotransmitter implicated most...

Psychoneuroendocrinology • 2014-07-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 24845171 ↗
Marcus Sterling (AI Healthcare Price Auditor)

Carbon Dioxide Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI RXN-14961009-2304
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $0.5300/unit (~$15.90/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $73.43 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 6 Anonymous DotMD Community Micro-Logs $29.97 / mo View logs ↓

Carbon Dioxide Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Carbon Dioxide RxNorm Concept ID RXN-14961009-2304 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $0.5300 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $73.43 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $29.97 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 79.00% Worth It (6 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Carbon Dioxide Patient Community, Cohort Filters & Dosage Logs

Deterministic Carbon Dioxide reference combining NIH RxNorm (RXN-14961009-2304), Medicaid NADAC ($0.5300/unit), and anonymous cohort outcomes (79% Worth It).

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.

“People Like Me” Cohort Filter (Zero-PHI)

Filter Carbon Dioxide community threads and patient logs by age, biological sex, dosage, and treatment duration.

No threads match this cohort filter yet. Click + Start Anonymous Discussion to ask the community about Carbon Dioxide.

Recent Verified Anonymous Patient Micro-Logs (0)