Cetirizine Hydrochloride

Indications and usage: Perennial Allergic Rhinitis: Cetirizine hydrochloride is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in children 6 to 23 months of age. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing. Chronic Urticaria: Cetirizine hydrochloride is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in children 6 months to 5 years of age.

Mechanism of Actions: Cetirizine, a human metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H 1 receptors. The antihistaminic activity of cetirizine has been clearly documented in a variety of animal and human models. In vivo and ex vivo animal models have shown negligible anticholinergic and antiserotonergic activity. In clinical studies, however, dry mouth was more common with cetirizine than with placebo. In vitro receptor binding studies have shown no measurable affinity for other than H 1 receptors.

With Biphasic clearance with 11–22 hr terminal t½ under Cetirizine Hydrochloride maintenance residence kinetics and Systemic oral bioavailability of roughly 68%–80% following first-pass transit bioavailability, Cetirizine Hydrochloride undergoes hepatic enzymatic processing and renal clearance proportional to creatinine clearance (cetirizine hydrochloride) and establishes therapeutic activity over peak plasma tmax within 1 hour (cetirizine hydrochloride).

Standard adult regimens span 10 mg/1 Tablet, 10 mg/1 Tablet, Film Coated, 5 mg/5mL Solution, 10 mg/1 Tablet, Orally Disintegrating, 10 mg/1 Tablet, Coated. Prescribers screen specifically against contraindications cetirizine hydrochloride is contraindicated in those patients with a known hypersensitivity to it or any of its ingredients or hydroxyzine.; severe drug-induced hypersensitivity to cetirizine hydrochloride or inactive tablet/vehicle binders, while community micro-logs most frequently note nausea (8.4% of reports), headache (7% of reports), dizziness (5% of reports).