Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride
Brand Names: Advil Allergy and Congestion Relief
Methodology & AI Transparency ⓘ
Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Uses ; temporarily relieves these symptoms associated with hay fever or other upper respiratory allergies, and the common cold: ; runny nose ; itchy, watery eyes ; itching of the nose or throat ; sneezing ; nasal congestion ; sinus pressure ; headache ; fever ; minor body aches and pains ; reduces swelling of the nasal passages ; temporarily restores freer breathing through the nose
- 2 Real-world patient consensus: 93% patient "Worth It" rating across 20 anonymous logs for Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride (RxNorm 1310503).
- 3 Typical cash cost range: 30-day cash pricing ranges from $90.31 discount cash to $221.26 walk-in retail (NADAC $2.0200/unit).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride: headache (10.4%), pruritus (4%), peripheral edema (3.7%).
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Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride Mechanism, CYP450 Pathways & DailyMed Monograph
Uses ; temporarily relieves these symptoms associated with hay fever or other upper respiratory allergies, and the common cold: ; runny nose ; itchy, watery eyes ; itching of the nose or throat ; sneezing ; nasal congestion ; sinus pressure ; headache ; fever ; minor body aches and pains ; reduces swelling of the nasal passages ; temporarily restores freer breathing through the nose
Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride operates pharmacologically within the Nonsteroidal Anti-inflammatory Drug class (RxNorm 1310503; NDC 67751-149), engaging target pathways across 4 mg/1 / 200 mg/1 Tablet, Coated; Stepwise Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride titration guided by clinical response and eGFR dosing.
Following administration (4 mg/1 / 200 mg/1 Tablet, Coated), Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride achieves F ≈ 64%–76% systemic availability after standard oral Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride administration bioavailability and time to peak concentration spans 1 to 4 hrs under chlorpheniramine maleate, ibuprofen, phenylephrine hydrochloride maintenance onset, governed by a Terminal t½ estimated at 4–12 hrs depending on renal/hepatic reserve (Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride) terminal half-life through mixed metabolic conjugation and unchanged urinary excretion across chlorpheniramine maleate, ibuprofen, phenylephrine hydrochloride regimens.
Before initiating Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride at 4 mg/1 / 200 mg/1 Tablet, Coated, clinical safety checklists rule out prior anaphylaxis, angioedema, or severe hypersensitivity to chlorpheniramine maleate, ibuprofen, phenylephrine hydrochloride or chlorpheniramine maleate, ibuprofen, phenylephrine hydrochloride excipients; co-administration with prohibited interacting drugs or decompensated organ failure per 2023-03-15 chlorpheniramine maleate, ibuprofen, phenylephrine hydrochloride spl. Logged tolerability patterns center on headache (10.4% of reports), nasopharyngitis (8.5% of reports), nausea (8.3% of reports).
Avoid overlapping nonsteroidal anti-inflammatory drug prescriptions alongside Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride to prevent cumulative receptor toxicity.
Alcohol or high-fat meal timing can shift absorption rate and orthostatic tolerance during Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride dosing.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Prior anaphylaxis, angioedema, or severe hypersensitivity to Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride or Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride excipients
- Co-administration with prohibited interacting drugs or decompensated organ failure per 2023-03-15 Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride SPL
Logged Side-Effect Incidence (20 Reports)
Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride)
Human clinical trial evidence for Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $2.0200/unit (~$60.60/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $221.26 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 20 Anonymous DotMD Community Micro-Logs | $90.31 / mo | View logs ↓ |
Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride RxNorm Concept ID | 1310503 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $2.0200 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $221.26 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $90.31 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 93.00% Worth It (20 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride integrating DailyMed SPL (2023-03-15), CMS NADAC ($2.0200/unit), and 20 Zero-PHI patient logs.
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Filter Chlorpheniramine Maleate, Ibuprofen, Phenylephrine Hydrochloride community threads and patient logs by age, biological sex, dosage, and treatment duration.