Brand Reference: Clomid, Serophene
| Metric | Verified Benchmark | Source |
|---|---|---|
| Clomiphene Citrate (Racemic Enclomiphene / Zuclomiphene) RxNorm Concept ID | 2596 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $1.4200 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $124.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $34.50 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $42.00 / mo | 27 Zero-PHI Verified Patient Logs |
62:38 mixture of trans-enclomiphene and cis-zuclomiphene that antagonizes hypothalamic ER-alpha receptors to stimulate pituitary LH and FSH secretion for ovulation induction and off-label male secondary hypogonadism.
Out-of-pocket price dispersion on Clomiphene Citrate (Racemic Enclomiphene / Zuclomiphene) spans $34.50 to $124.00 per 30-day fill: pharmacy acquisition benchmarks sit near $1.4200/unit, allowing cash buyers bypassing PBM spread pricing to retain $89.50 each month (72% reduction).
With Enclomiphene ~10h / Zuclomiphene 14–30 days residence kinetics and ~85% oral bioavailability, Clomiphene Citrate (Racemic Enclomiphene / Zuclomiphene) undergoes enterohepatic recirculation and cyp2d6 metabolism and establishes therapeutic activity over 2–3 weeks gonadotropin rise.
Standard adult regimens span 25 mg PO every other day, 25 mg PO daily, 50 mg PO every other day. Prescribers screen specifically against retinal scotomata or blurred vision; hepatic dysfunction; hormone-sensitive pituitary lesion, while community micro-logs most frequently note emotional lability (zuclomiphene accumulation) (24% of reports), shbg elevation (19% of reports), visual floaters (9% of reports).
Across 27 verified cash-pay logs, Clomiphene Citrate (Racemic Enclomiphene / Zuclomiphene) achieves a 74.20% Worth-It rating with out-of-pocket spend averaging $42.00/mo versus $124.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 25 mg PO every other day for Clomiphene Citrate (Racemic Enclomiphene / Zuclomiphene); monthly out-of-pocket dropped to $30.36 compared with $124.00 retail.
Completed 10 weeks on Clomiphene Citrate (Racemic Enclomiphene / Zuclomiphene) (25 mg PO daily). Zero notable side effects on steady dosing.
Consistent biomarker response on 50 mg PO every other day Clomiphene Citrate (Racemic Enclomiphene / Zuclomiphene) sourced via Local Pharmacy ($40.02/mo cash pay without insurance prior authorization).