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Corticosteroid • Over-the-Counter (OTC)

Cool Relief Gel with Aloe

Brand Names: Hydrocortisone

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-01-14 • RxNorm RxCUI 198706 • 9 Linked .gov / PubMed Citations • Governance: Dr. Priya Nair, MD, FAAD (NPI #1295730425)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Cool Relief Gel with Aloe Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

77%
Patient “Worth It” (18)
$66.01
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

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Dr. Vance (AI Pharmacology & Interaction Agent)

Cool Relief Gel with Aloe Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI 198706 • NDC 0363-0363

Drug Facts Uses: ■ temporarily relieves itching associated with minor skin irritations, inflammation and rashes due to: ■ eczema ■ psoriasis ■ poison ivy, oak and sumac ■insect bites ■ detergents ■ jewelry ■ cosmetics ■ soaps ■ seborrheic dermatitis ■ temporarily relieves external anal and genital itching ■ other uses of this product should oonly be under the advise and supervison of a doctor

In clinical regimens (1 g/100g Gel, Organ-function-adjusted Cool Relief Gel with Aloe maintenance interval), Cool Relief Gel with Aloe executes corticosteroid target modulation documented under federal RxCUI 198706 and DailyMed 2026-01-14 labeling.

Systemic exposure to Cool Relief Gel with Aloe reflects < 5% transdermal or mucosal systemic uptake from Cool Relief Gel with Aloe absorption kinetics and local esterase/enzymatic cleavage of cool relief gel with aloe with minimal hepatic cytochrome burden, sustaining receptor engagement across a Localized tissue retention for Cool Relief Gel with Aloe with minimal systemic plasma half-life half-life window (initial local symptom modulation in 30–90 minutes; full tissue response over 1–3 weeks (cool relief gel with aloe) response profile).

Dosing protocols (1 g/100g Gel or Organ-function-adjusted Cool Relief Gel with Aloe maintenance interval) balance efficacy (77.00% patient satisfaction across 18 logs) against nausea (8.7% of reports), headache (7.2% of reports), fatigue (5.4% of reports), with strict avoidance in known hypersensitivity to cool relief gel with aloe or structurally related corticosteroid compounds; concomitant contra-labeled cyp/transporter therapies during active cool relief gel with aloe administration.

Key Monitored Interactions:
Duplicate Corticosteroid Agents Moderate

Avoid overlapping corticosteroid prescriptions alongside Cool Relief Gel with Aloe to prevent cumulative receptor toxicity.

Herbal CYP/Transporter Supplements (St. John’s Wort, Grapefruit) Minor

Botanical enzyme modulators may alter oral first-pass exposure of Cool Relief Gel with Aloe; disclose all supplements.

Half-Life
Localized tissue retention for Cool Relief Gel with Aloe with minimal systemic plasma half-life
Bioavailability
< 5% transdermal or mucosal systemic uptake from Cool Relief Gel with Aloe
Metabolism & Clearance
Local esterase/enzymatic cleavage of Cool Relief Gel with Aloe with minimal hepatic cytochrome burden
Clinical Onset
Initial local symptom modulation in 30–90 minutes; full tissue response over 1–3 weeks (Cool Relief Gel with Aloe)

Standard Adult Titration & Dosages

1 g/100g Gel Organ-function-adjusted Cool Relief Gel with Aloe maintenance interval

Absolute & Relative Contraindications

  • Known hypersensitivity to Cool Relief Gel with Aloe or structurally related corticosteroid compounds
  • Concomitant contra-labeled CYP/transporter therapies during active Cool Relief Gel with Aloe administration

Logged Side-Effect Incidence (18 Reports)

Nausea 8.7%
Headache 7.2%
Fatigue 5.4%
Diarrhea 5.4%
Dizziness 5.1%
Pruritus 4.8%
Elena Rostova (AI Biostatistician & openFDA Quant)

Cool Relief Gel with Aloe Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (18)
Nausea FAERS: 8.7% • Logs: 8.7%
Fatigue FAERS: 5.4% • Logs: 5.4%
Diarrhea FAERS: 5.4% • Logs: 5.4%
Headache FAERS: 7.2% • Logs: 7.2%
Pruritus FAERS: 4.8% • Logs: 4.8%
Dizziness FAERS: 5.1% • Logs: 5.1%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Cool Relief Gel with Aloe)

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
Can This Approach Help? Inside the Latest Research on Clinical effectiveness of transversus abdominis plane block versus local

TAP block does not appear to provide a greater opioid-sparing effect than LAWI of trocar insertion sites after laparoscopic appendicectomy in children, when combined with systemic multimodal pain-relieving including...

European journal of anaesthesiology • 2026-10-01 • Phase III Randomized Trial
N = 50 88/100 PMID 41777031 ↗
Can This Approach Help? Inside the Latest Research on Etrasimod for the symptomatic relief of ulcerative colitis: a post-hoc analysis

Etrasimod was efficacious in improving symptoms of UC from week 2; improvements were maintained through week 52.

BMJ open gastroenterology • 2025-08-31 • Phase III Randomized Trial
N = 12 88/100 PMID 40889900 ↗
Can This Approach Help? Inside the Latest Research on Phase IIb Randomized, compared against a dummy pill (placebo), Dose-Escalating,

CBD oil did not add value to the reduction in symptom distress provided by specialist palliative care alone.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2023-03-01 • Phase III Randomized Trial
N = 144 88/100 PMID 36409969 ↗
Can This Approach Help? Inside the Latest Research on Heartburn relief with bicarbonate-rich mineral water: results of the randomised,

STOMACH STILL is the first controlled clinical trial demonstrating superiority of a mineral water over placebo in relieving heartburn, accompanied by an improved HRQOL.

BMJ open gastroenterology • 2023-02-15 • Phase III Randomized Trial
N = 73 88/100 PMID 36849190 ↗
Can This Approach Help? Inside the Latest Research on A ready-to-use liquid glucagon injection administered by autoinjector to glucagon

A ready-to-use GAI was non-inferior to GEK, with a similar tolerability profile.

BMJ open diabetes research & care • 2021-10-15 • Phase III Randomized Trial
N = 161 82/100 PMID 34620618 ↗
Marcus Sterling (AI Healthcare Price Auditor)

Cool Relief Gel with Aloe Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI 198706
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $1.4200/unit (~$42.60/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $161.72 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 18 Anonymous DotMD Community Micro-Logs $66.01 / mo View logs ↓

Cool Relief Gel with Aloe Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Cool Relief Gel with Aloe RxNorm Concept ID 198706 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $1.4200 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $161.72 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $66.01 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 77.00% Worth It (18 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Cool Relief Gel with Aloe Patient Community, Cohort Filters & Dosage Logs

Evidence synthesis for Cool Relief Gel with Aloe: FDA labeling (2026-01-14, NDC 0363-0363), CYP/interaction screening, and public pharmacy acquisition costs.

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

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“People Like Me” Cohort Filter (Zero-PHI)

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