Demeclocycline Hydrochloride
Brand Names: Declomycin
Methodology & AI Transparency ⓘ
Demeclocycline Hydrochloride Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Indications and usage: Demeclocycline hydrochloride tablets USP is indicated in the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions below: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by rickettsiae; Respiratory tract infections caused by Mycoplasma pneumoniae ; Lymphogranuloma venereum due to Chlamydia trachomatis ; Psittacosis (Ornithosis) due to Chlamydia psittaci ; Trachoma due to Chlamydia trachomatis , although the infectious agent is not always eliminated, as judged by.
- 2 Real-world patient consensus: 82% patient "Worth It" rating across 18 anonymous logs for Demeclocycline Hydrochloride (RxNorm 905341).
- 3 Typical cash cost range: 30-day cash pricing ranges from $50.21 on Cost Plus Drugs to $123.01 walk-in retail (NADAC $2.1230/unit).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Demeclocycline Hydrochloride: nausea (11%), diarrhea (8.3%), vomiting (4.6%).
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Demeclocycline Hydrochloride Mechanism, CYP450 Pathways & DailyMed Monograph
Indications and usage: Demeclocycline hydrochloride tablets USP is indicated in the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions below: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by rickettsiae; Respiratory tract infections caused by Mycoplasma pneumoniae ; Lymphogranuloma venereum due to Chlamydia trachomatis ; Psittacosis (Ornithosis) due to Chlamydia psittaci ; Trachoma due to Chlamydia trachomatis , although the infectious agent is not always eliminated, as judged by.
CLINICAL PHARMACOLOGY Pharmacokinetics The absorption of demeclocycline is slower than that of tetracycline. The time to reach the peak concentration is about 4 hours. After a 150 mg oral dose of demeclocycline tablet, the mean concentrations at 1 hour and 3 hours are 0.46 and 1.22 mcg/mL (n = 6), respectively. The serum half-life ranges between 10 and 16 hours. When demeclocycline hydrochloride is given concomitantly with some dairy products, or antacids containing aluminum, calcium, or magnesium, the extent of absorption is reduced by more than 50%.
Pharmacokinetic profiling of Demeclocycline Hydrochloride demonstrates an elimination half-life of 16 hours terminal elimination (Demeclocycline Hydrochloride SPL) with Systemic oral bioavailability of roughly 67%–79% following first-pass transit systemic bioavailability; clearance proceeds via hepatic enzymatic processing and renal clearance proportional to creatinine clearance (demeclocycline hydrochloride), reaching clinical onset within initial pharmacodynamic onset within 1–3 hrs (peak cmax) for demeclocycline hydrochloride.
Titration schedules for Demeclocycline Hydrochloride (150 mg/1 Tablet, Film Coated → 300 mg/1 Tablet, Film Coated → 150mg Tablet → 300mg Tablet) require excluding contraindications this drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines or any of the components of the product formulation.; prior anaphylaxis, angioedema, or severe hypersensitivity to demeclocycline hydrochloride or demeclocycline hydrochloride excipients; real-world patient logs highlight nausea (11% of reports), diarrhea (8.3% of reports), headache (5.5% of reports) alongside a 82.00% Worth-It consensus.
Co-administering Demeclocycline Hydrochloride with coumarin anticoagulants can shift prothrombin INR values and heighten hemorrhage risk.
Chelation with aluminum, magnesium, calcium, or iron in the gut lumen can lower oral Demeclocycline Hydrochloride absorption; stagger doses by 2–4 hours.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- CONTRAINDICATIONS This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines or any of the components of the product formulation.
- Prior anaphylaxis, angioedema, or severe hypersensitivity to Demeclocycline Hydrochloride or Demeclocycline Hydrochloride excipients
Logged Side-Effect Incidence (18 Reports)
Demeclocycline Hydrochloride Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Demeclocycline Hydrochloride)
Human clinical trial evidence for Demeclocycline Hydrochloride is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Demeclocycline Hydrochloride Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $2.1230/unit (~$63.69/30u) | Wholesale baseline |
| Mark Cuban Cost Plus Drugs (Mail-Order Generic) | Public Wholesale Price List (NADAC + 15% + pharmacy fee) | $50.21 / mo | Formulary listing ↗ |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $123.01 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 18 Anonymous DotMD Community Micro-Logs | $57.74 / mo | View logs ↓ |
Demeclocycline Hydrochloride Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Demeclocycline Hydrochloride RxNorm Concept ID | 905341 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $2.1230 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $123.01 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $50.21 / mo (Cost Plus Drugs) | Mark Cuban Cost Plus Public API |
| Real-World Patient Consensus | 82.00% Worth It (18 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Demeclocycline Hydrochloride Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Demeclocycline Hydrochloride integrating DailyMed SPL (2025-12-11), CMS NADAC ($2.1230/unit), and 18 Zero-PHI patient logs.
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Filter Demeclocycline Hydrochloride community threads and patient logs by age, biological sex, dosage, and treatment duration.