Diphenhydramine Hydrochloride
Brand Names: Allergy Childrens Allergy, Axiv - Vrozzz, Basic Care Allergy Relief, Diphenhydramine HCl Oral Solution, Allergy Relief, Diphenhydramine Oral Liquid
Methodology & AI Transparency ⓘ
Diphenhydramine Hydrochloride Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Indications and usage: Diphenhydramine hydrochloride in the oral form is effective for the following indications: Antihistaminic For allergic conjunctivitis due to foods; mild, uncomplicated allergic skin manifestations of urticaria and angioedema; amelioration of allergic reactions to blood or plasma; dermatographism; as therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.
- 2 Real-world patient consensus: Tracked across 12 patient dosage logs with a 80% satisfaction benchmark (RxCUI 1049906).
- 3 Typical cash cost range: Public pharmacy ledger: $5.27 low cash benchmark vs. $34.50 chain retail average ($0.0159/unit CMS NADAC).
- 4 Top reported side effects / signs: Key post-marketing and trial adverse reactions (Diphenhydramine Hydrochloride): headache (10.6%), dizziness (6.3%), fatigue (6.1%).
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Diphenhydramine Hydrochloride Mechanism, CYP450 Pathways & DailyMed Monograph
Indications and usage: Diphenhydramine hydrochloride in the oral form is effective for the following indications: Antihistaminic For allergic conjunctivitis due to foods; mild, uncomplicated allergic skin manifestations of urticaria and angioedema; amelioration of allergic reactions to blood or plasma; dermatographism; as therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled. Motion Sickness For active and prophylactic treatment of motion sickness.
CLINICAL PHARMACOLOGY Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. A single oral dose of diphenhydramine hydrochloride is quickly absorbed with maximum activity occurring in approximately one hour. The duration of activity following an average dose of diphenhydramine hydrochloride is from four to six hours. Diphenhydramine is widely distributed throughout the body, including the CNS.
Clinical clearance of Diphenhydramine Hydrochloride (Histamine-1 Receptor Antagonist) relies on phase i/ii hepatic conjugation of diphenhydramine hydrochloride coupled with glomerular and tubular renal excretion with a Approximately 6–10 hours terminal plasma half-life for Diphenhydramine Hydrochloride half-life; patients absorbing at Estimated 65%–77% oral systemic absorption for Diphenhydramine Hydrochloride bioavailability typically observe target onset around peak plasma concentration (tmax) reached 1–3 hours post-dose for diphenhydramine hydrochloride.
FDA clinical labeling for Diphenhydramine Hydrochloride restricts administration in contraindications use in neonates or premature infants this drug should not be used in neonates or premature infants.; documented intolerance or hypersensitivity reaction involving diphenhydramine hydrochloride (histamine-1 receptor antagonist) across 25 mg/1 Tablet, 25 mg/1 Tablet, Film Coated, 25 mg/1 Capsule, 50 mg/mL Injection, Solution, 12.5 mg/5mL Liquid, with self-reported patient tracking dominated by headache (10.6% of reports), insomnia (6.3% of reports), dizziness (6.3% of reports).
Patients taking Diphenhydramine Hydrochloride should avoid unmonitored CNS depressants due to compounded vigilance impairment.
Assess baseline hepatic panels and interacting prescriptions when starting Diphenhydramine Hydrochloride (histamine-1 receptor antagonist).
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- CONTRAINDICATIONS Use in Neonates or Premature Infants This drug should not be used in neonates or premature infants.
- Documented intolerance or hypersensitivity reaction involving Diphenhydramine Hydrochloride (histamine-1 receptor antagonist)
Logged Side-Effect Incidence (12 Reports)
Diphenhydramine Hydrochloride Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Diphenhydramine Hydrochloride)
Human clinical trial evidence for Diphenhydramine Hydrochloride is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Diphenhydramine Hydrochloride Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.0159/unit (~$0.48/30u) | Wholesale baseline |
| Mark Cuban Cost Plus Drugs (Mail-Order Generic) | Public Wholesale Price List (NADAC + 15% + pharmacy fee) | $5.27 / mo | Formulary listing ↗ |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 12 Anonymous DotMD Community Micro-Logs | $7.50 / mo | View logs ↓ |
Diphenhydramine Hydrochloride Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Diphenhydramine Hydrochloride RxNorm Concept ID | 1049906 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0159 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $5.27 / mo (Cost Plus Drugs) | Mark Cuban Cost Plus Public API |
| Real-World Patient Consensus | 80.00% Worth It (12 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Diphenhydramine Hydrochloride Patient Community, Cohort Filters & Dosage Logs
Evidence synthesis for Diphenhydramine Hydrochloride: FDA labeling (2024-04-05, NDC 55910-891), CYP/interaction screening, and public pharmacy acquisition costs.
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Filter Diphenhydramine Hydrochloride community threads and patient logs by age, biological sex, dosage, and treatment duration.