Ferrous Fumarate, Folic Acid
Brand Names: Vitrexate Fe, Vitrexyl Plus Iron, Venexa Fe, Ventrixyl Fe, Folitin-Z, Vitranol Fe
Methodology & AI Transparency ⓘ
Ferrous Fumarate, Folic Acid Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: INDICATIONS: Vitrexate FE is indicated for the treatment of iron deficiency anemia and folate deficiency as in extended convalescence, menorrhagia, pregnancy, puberty, excessive blood loss and advanced age.Also for the treatment of a condition in which iron deficiency and vitamin C deficiency occur together, along with a deficient intake or increased need for B-Complex vitamins in chronic and acute illness, as well as cases of metabolic stress, and in convalescence.
- 2 Real-world patient consensus: Real-world cohort score of 86% across 10 de-identified Ferrous Fumarate, Folic Acid entries.
- 3 Typical cash cost range: Uninsured 30-day outlay compares $28.34 cash mean against $69.43 retail pharmacy pricing.
- 4 Top reported side effects / signs: Key post-marketing and trial adverse reactions (Ferrous Fumarate, Folic Acid): nausea (10.5%), diarrhea (7.8%), constipation (5%).
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Ferrous Fumarate, Folic Acid Mechanism, CYP450 Pathways & DailyMed Monograph
INDICATIONS: Vitrexate FE is indicated for the treatment of iron deficiency anemia and folate deficiency as in extended convalescence, menorrhagia, pregnancy, puberty, excessive blood loss and advanced age.Also for the treatment of a condition in which iron deficiency and vitamin C deficiency occur together, along with a deficient intake or increased need for B-Complex vitamins in chronic and acute illness, as well as cases of metabolic stress, and in convalescence.
In clinical regimens (1500 ug/1 / 250 mg/1 Tablet, 35 ug/1 / 1000 ug/1 Tablet), Ferrous Fumarate, Folic Acid executes vitamin b12 target modulation documented under federal RxCUI RXN-59088168-2006 and DailyMed 2023-01-11 labeling.
With Steady-state plasma equilibrium reached over 9–14 hour t½ intervals for Ferrous Fumarate, Folic Acid residence kinetics and Approximately 71% to 83% enteral uptake across labeled Ferrous Fumarate, Folic Acid strengths bioavailability, Ferrous Fumarate, Folic Acid undergoes predominantly hepatic biotransformation with renal elimination of polar ferrous fumarate, folic acid conjugates and establishes therapeutic activity over maximum serum exposure occurs 2–4 hours after ferrous fumarate, folic acid dosing.
Standard adult regimens span 1500 ug/1 / 250 mg/1 Tablet, 35 ug/1 / 1000 ug/1 Tablet, 200 mg/1 / 2.6 mg/1 Tablet, 27 mg/1 / 25 mg/1 Tablet. Prescribers screen specifically against contraindications: this product is contraindicated in patients with known hypersensitivity to any of its ingredients; also, all iron compounds are contraindicated in patients with hemosiderosis, hemochromatosis, or hemolytic anemias.; pernicious anemia is a contraindication, as folic acid may obscure its signs and symptoms., while community micro-logs most frequently note nausea (10.5% of reports), headache (8.6% of reports), diarrhea (7.8% of reports).
Monitor kidney function and gastrointestinal symptoms when Ferrous Fumarate, Folic Acid overlaps with daily NSAID analgesia.
Verify medication reconciliation lists so Ferrous Fumarate, Folic Acid is not inadvertently duplicated with another vitamin b12.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- CONTRAINDICATIONS: This product is contraindicated in patients with known hypersensitivity to any of its ingredients
- also, all iron compounds are contraindicated in patients with hemosiderosis, hemochromatosis, or hemolytic anemias.
- Pernicious anemia is a contraindication, as folic acid may obscure its signs and symptoms.
Logged Side-Effect Incidence (10 Reports)
Ferrous Fumarate, Folic Acid Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Ferrous Fumarate, Folic Acid)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| Can This Approach Help? Inside the Latest Research on Benefits and safety of ferric citrate hydrate compared with sodium ferrous The incidences of nausea and vomiting were significantly lower in the FC treatment groups than in the SF group. International journal of hematology • 2021-07-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 33719027 ↗ |
| Can This Approach Help? Inside the Latest Research on A phase III gold-standard blind, compared against a dummy pill (placebo), These findings suggest that SPP-004 is safe and may provide therapeutic effect for LS patients who achieved an initial clinical response. PloS one • 2026-01-15 • Phase III Randomized Trial | N = 54 | 88/100 | PMID 42467686 ↗ |
Ferrous Fumarate, Folic Acid Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.4900/unit (~$14.70/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $69.43 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 10 Anonymous DotMD Community Micro-Logs | $28.34 / mo | View logs ↓ |
| Hone Health Hormone & At-Home Biomarker Lab (Licensed Telehealth Cash Program) | State-licensed clinician review • ~3d mail fulfillment | $65.00 consult | Program details |
Ferrous Fumarate, Folic Acid Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Ferrous Fumarate, Folic Acid RxNorm Concept ID | RXN-59088168-2006 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.4900 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $69.43 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $28.34 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 86.00% Worth It (10 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Ferrous Fumarate, Folic Acid Patient Community, Cohort Filters & Dosage Logs
Deterministic Ferrous Fumarate, Folic Acid reference combining NIH RxNorm (RXN-59088168-2006), Medicaid NADAC ($0.4900/unit), and anonymous cohort outcomes (86% Worth It).
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