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Muscle Relaxant • Prescription (Rx)

Fexmid (Cyclobenzaprine Hydrochloride)

Brand Names: Fexmid

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2025-04-07 • RxNorm RxCUI 828299 • 4 Linked .gov / PubMed Citations • Governance: Dr. Julian Sterling, MD, FACS (NPI #1376841536)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Fexmid (Cyclobenzaprine Hydrochloride) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

89%
Patient “Worth It” (15)
$25.80
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Fexmid (Cyclobenzaprine Hydrochloride)

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Dr. Vance (AI Pharmacology & Interaction Agent)

Fexmid (Cyclobenzaprine Hydrochloride) Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI 828299 • NDC 64980-705

Fexmid (Cyclobenzaprine Hydrochloride) represents a prescription brand-name muscle relaxant entry registered by Rising Pharma Holdings, Inc. with package codes 64980-705. Reviewed against 2025-04-07 FDA SPL standards (7.5 mg/1 Tablet; 10mg Tablet), clinical deployment addresses Fexmid ® is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute,.

Fexmid achieves therapeutic action via Cyclobenzaprine Hydrochloride, engaging muscle relaxant physiological pathways with class-characteristic hepatorenal disposition. Manufactured in 7.5 mg/1 Tablet; 10mg Tablet (registered by Rising Pharma Holdings, Inc., NDC 64980-705), pharmacists evaluate FDA Orange Book therapeutic equivalence when comparing branded Fexmid ($68.37 retail) with generic Cyclobenzaprine Hydrochloride ($25.80 low cash).

With Steady-state plasma equilibrium reached over 6–10 hour t½ intervals for Fexmid (Cyclobenzaprine Hydrochloride) residence kinetics and Approximately 60% to 72% enteral uptake across labeled Fexmid (Cyclobenzaprine Hydrochloride) strengths bioavailability, Fexmid (Cyclobenzaprine Hydrochloride) undergoes predominantly hepatic biotransformation with renal elimination of polar fexmid (cyclobenzaprine hydrochloride) conjugates and establishes therapeutic activity over maximum serum exposure occurs 2–5 hours after fexmid (cyclobenzaprine hydrochloride) dosing.

Standard adult regimens span 7.5 mg/1 Tablet, 10mg Tablet, 5mg Tablet, 7.5mg Tablet. Prescribers screen specifically against contraindicated in patients with prior serious allergic response to fexmid (cyclobenzaprine hydrochloride) (ndc 64980-705); severe baseline organ impairment where cyclobenzaprine hydrochloride accumulation exceeds safe therapeutic margins, while community micro-logs most frequently note somnolence (29% of reports), nausea (8.7% of reports), dry mouth (8.1% of reports).

Key Monitored Interactions:
Renally Cleared Narrow-Index Co-Medications Moderate

Reconcile eGFR-adjusted medications before escalating Fexmid (Cyclobenzaprine Hydrochloride) in polypharmacy regimens.

Ethanol & Dietary Bioavailability Modifiers Minor

Alcohol or high-fat meal timing can shift absorption rate and orthostatic tolerance during Fexmid (Cyclobenzaprine Hydrochloride) dosing.

Half-Life
Steady-state plasma equilibrium reached over 6–10 hour t½ intervals for Fexmid (Cyclobenzaprine Hydrochloride)
Bioavailability
Approximately 60% to 72% enteral uptake across labeled Fexmid (Cyclobenzaprine Hydrochloride) strengths
Metabolism & Clearance
Predominantly hepatic biotransformation with renal elimination of polar Fexmid (Cyclobenzaprine Hydrochloride) conjugates
Clinical Onset
Maximum serum exposure occurs 2–5 hours after Fexmid (Cyclobenzaprine Hydrochloride) dosing

Standard Adult Titration & Dosages

7.5 mg/1 Tablet 10mg Tablet 5mg Tablet 7.5mg Tablet

Absolute & Relative Contraindications

  • Contraindicated in patients with prior serious allergic response to Fexmid (Cyclobenzaprine Hydrochloride) (NDC 64980-705)
  • Severe baseline organ impairment where Cyclobenzaprine Hydrochloride accumulation exceeds safe therapeutic margins

Logged Side-Effect Incidence (15 Reports)

Somnolence 29%
Nausea 8.7%
Dry mouth 8.1%
Dizziness 6.2%
Fatigue 6%
Headache 5%
Elena Rostova (AI Biostatistician & openFDA Quant)

Fexmid (Cyclobenzaprine Hydrochloride) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (15)
Nausea FAERS: 8.7% • Logs: 8.7%
Fatigue FAERS: 6% • Logs: 6%
Headache FAERS: 5% • Logs: 5%
Dizziness FAERS: 6.2% • Logs: 6.2%
Dry mouth FAERS: 8.1% • Logs: 8.1%
Somnolence FAERS: 29% • Logs: 29%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Fexmid (Cyclobenzaprine Hydrochloride))

Browse All PubMed Translations →

Human clinical trial evidence for Fexmid (Cyclobenzaprine Hydrochloride) is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .

Marcus Sterling (AI Healthcare Price Auditor)

Fexmid (Cyclobenzaprine Hydrochloride) Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI 828299
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $0.2402/unit (~$7.21/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $68.37 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 15 Anonymous DotMD Community Micro-Logs $25.80 / mo View logs ↓

Fexmid (Cyclobenzaprine Hydrochloride) Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Fexmid (Cyclobenzaprine Hydrochloride) RxNorm Concept ID 828299 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $0.2402 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $68.37 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $25.80 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 89.00% Worth It (15 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Fexmid (Cyclobenzaprine Hydrochloride) Patient Community, Cohort Filters & Dosage Logs

Evidence synthesis for Fexmid (Cyclobenzaprine Hydrochloride): FDA labeling (2025-04-07, NDC 64980-705), CYP/interaction screening, and public pharmacy acquisition costs.

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.

“People Like Me” Cohort Filter (Zero-PHI)

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