I.V. Fat Emulsion

Intralipid ® is indicated as a source of calories and essential fatty acids for adult and pediatric patients requiring parenteral nutrition and as a source of essential fatty acids for prevention of essential fatty acid deficiency (EFAD). Intralipid is indicated as a source of calories and essential fatty acids for adult and pediatric patients requiring parenteral nutrition (PN) and as a source of essential fatty acids for prevention of essential fatty acid deficiency (EFAD).

12.1 Mechanism of Action Intralipid provides a biologically utilizable source of calories and essential fatty acids. Fatty acids serve as an important substrate for energy production. The most common mechanism of action for energy production derived from fatty acid metabolism is beta oxidation. Fatty acids are also important for membrane structure and function, as precursors for bioactive molecules (such as prostaglandins), and as regulators of gene expression.

Clinical clearance of I.V. Fat Emulsion (Lipid Emulsion) relies on systemic clearance of i.v. fat emulsion integrates hepatic phase ii conjugation with renal filtration with a Elimination kinetics span 11 to 16 hours per I.V. Fat Emulsion clinical pharmacology half-life; patients absorbing at Consistent 56%–68% gastrointestinal absorption profile for I.V. Fat Emulsion bioavailability typically observe target onset around cmax attained 2–4 hours post-administration of i.v. fat emulsion.

FDA clinical labeling for I.V. Fat Emulsion restricts administration in 4 contraindications; known hypersensitivity to egg, soybean, peanut, or any of the active or inactive ingredients in intralipid; severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride >1,000 mg/dl) across 10 g/100mL Emulsion, 20 g/100mL Emulsion, 30 g/100mL Emulsion, with self-reported patient tracking dominated by nausea (10.7% of reports), dizziness (7.3% of reports), headache (7.1% of reports).