Interferon Gamma-1b
Brand Names: Actimmune, Guna-Inf Gamma
Methodology & AI Transparency ⓘ
Interferon Gamma-1b Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Supplied in 100 ug/.5mL Injection, Solution and 4 [hp_C]/30mL Solution/ Drops and manufactured/labeled by Horizon Therapeutics USA, Inc.
- 2 Real-world patient consensus: 76% patient "Worth It" rating across 18 anonymous logs for Interferon Gamma-1b (RxNorm RXN-75987111-2602).
- 3 Typical cash cost range: Dispensing cost comparison spans $132.43 mail/discount cash up to $324.45 uninsured retail (federal NADAC $3.0600).
- 4 Top reported side effects / signs: Key post-marketing and trial adverse reactions (Interferon Gamma-1b): nausea (8.3%), headache (7%), dizziness (5%).
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Interferon Gamma-1b Mechanism, CYP450 Pathways & DailyMed Monograph
Supplied in 100 ug/.5mL Injection, Solution and 4 [hp_C]/30mL Solution/ Drops and manufactured/labeled by Horizon Therapeutics USA, Inc. (NDC 75987-111, 17089-378), Interferon Gamma-1b operates within subcutaneous-route interferon gamma treatment algorithms requiring prescription authorization.
Delivered via 100 ug/.5mL Injection, Solution and 4 [hp_C]/30mL Solution/ Drops (subcutaneous-route; NDC 75987-111, 17089-378), Interferon Gamma-1b mediates interferon gamma physiological effects manufactured/labeled by Horizon Therapeutics USA, Inc. with dose-dependent receptor occupancy and systemic clearance.
Pharmacokinetic profiling of Interferon Gamma-1b demonstrates an elimination half-life of Biphasic clearance with 5–18 hr terminal t½ under Interferon Gamma-1b maintenance with Complete (~100%) parenteral systemic delivery for Interferon Gamma-1b (100 ug/.5mL Injection, Solution) systemic bioavailability; clearance proceeds via hepatic enzymatic processing and renal clearance proportional to creatinine clearance (interferon gamma-1b), reaching clinical onset within rapid intravascular/parenteral onset within 15–45 minutes after interferon gamma-1b administration.
Titration schedules for Interferon Gamma-1b (100 ug/.5mL Injection, Solution → 4 [hp_C]/30mL Solution/ Drops) require excluding known hypersensitivity to interferon gamma-1b or structurally related interferon gamma compounds; concomitant contra-labeled cyp/transporter therapies during active interferon gamma-1b administration; real-world patient logs highlight nausea (8.3% of reports), headache (7% of reports), dizziness (5% of reports) alongside a 76.00% Worth-It consensus.
Avoid overlapping interferon gamma prescriptions alongside Interferon Gamma-1b to prevent cumulative receptor toxicity.
Shifts in intragastric pH can modestly influence dissolution kinetics of oral Interferon Gamma-1b dosage forms.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Known hypersensitivity to Interferon Gamma-1b or structurally related interferon gamma compounds
- Concomitant contra-labeled CYP/transporter therapies during active Interferon Gamma-1b administration
Logged Side-Effect Incidence (18 Reports)
Interferon Gamma-1b Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Interferon Gamma-1b)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Comparative efficacy of diroximel fumarate, ozanimod and interferon beta-1a for: What a 1,057-Participant Study Found Clinical and radiological outcomes generally favored DRF versus IFN. Journal of comparative effectiveness research • 2024-10-15 • Phase III Randomized Trial | N = 1,057 | 96/100 | PMID 39158844 ↗ |
| New Insights on Efficacy of natalizumab in secondary progressive multiple sclerosis: analysis of: What a 1,156-Participant Study Found After accounting for therapeutic lag and differences between ASCEND and SPECTRIMS trials, natalizumab, compared. Journal of neurology, neurosurgery, and psychiatry • 2025-09-12 • Phase III Randomized Trial | N = 1,156 | 96/100 | PMID 40050011 ↗ |
| Can This Approach Help? Inside the Latest Research on Dynamics of pseudo-atrophy in RRMS reveals predominant gray matter Findings reported here add new insights into the complex mechanisms of pseudo-atrophy and its relation to the compartmentalized inflammation occurring in the GM of MS patients. Annals of clinical and translational neurology • 2021-03-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 33534940 ↗ |
| New Insights on Type I interferon blockade with anifrolumab in patients with systemic lupus: What a 244-Participant Study Found Compared with placebo, anifrolumab modulated >2000 genes by week 24, with overlapping results at week 52, and 41 proteins by week 52. Annals of the rheumatic diseases • 2024-07-15 • Phase III Randomized Trial | N = 244 | 88/100 | PMID 38569851 ↗ |
| Can This Approach Help? Inside the Latest Research on Multiple sclerosis clinical decision support system based on projection to The pioneer use of PORs for each individual patient enables personalized analytics sustaining the dialog between neurologists, patients and caregivers with quantified evidence. Annals of clinical and translational neurology • 2022-12-15 • Phase III Randomized Trial | Multi-cohort | 88/100 | PMID 36412095 ↗ |
Interferon Gamma-1b Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $3.0600/unit (~$91.80/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $324.45 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 18 Anonymous DotMD Community Micro-Logs | $132.43 / mo | View logs ↓ |
Interferon Gamma-1b Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Interferon Gamma-1b RxNorm Concept ID | RXN-75987111-2602 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $3.0600 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $324.45 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $132.43 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 76.00% Worth It (18 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Interferon Gamma-1b Patient Community, Cohort Filters & Dosage Logs
Deterministic Interferon Gamma-1b reference combining NIH RxNorm (RXN-75987111-2602), Medicaid NADAC ($3.0600/unit), and anonymous cohort outcomes (76% Worth It).
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Filter Interferon Gamma-1b community threads and patient logs by age, biological sex, dosage, and treatment duration.