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Over-the-Counter Clinical Monograph • Over-the-Counter (OTC)

Menstrual Bloat Relief (Pamabrom)

Brand Names: Menstrual Bloat Relief

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-04-07 • RxNorm RxCUI 199158 • 9 Linked .gov / PubMed Citations • Governance: Dr. Elena Vance, MD, FACE (NPI #1043218901)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Menstrual Bloat Relief (Pamabrom) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

86%
Patient “Worth It” (19)
$241.06
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Menstrual Bloat Relief (Pamabrom)

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Dr. Vance (AI Pharmacology & Interaction Agent)

Menstrual Bloat Relief (Pamabrom) Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI 199158 • NDC 79903-425

Marketed under the trade name Menstrual Bloat Relief (registered by WALMART INC., RxNorm 199158), this over-the-counter branded formulation contains Pamabrom within the Over-the-Counter Clinical Monograph therapeutic class. Per 2026-04-07 DailyMed labeling (79903-425, 70692-595), clinical use centers on 50 mg/1 Capsule, Liquid Filled; 50 mg/1 Tablet: Uses for the temporary relief of: bloating water-weight gain swelling full feeling associated with the premenstrual and.

At the receptor and enzymatic level, Menstrual Bloat Relief delivers Pamabrom to execute over-the-counter clinical monograph modulation with class-characteristic hepatorenal disposition. Specific to the Menstrual Bloat Relief commercial product (NDC 79903-425, 70692-595, RxCUI 199158), tablet/vehicle compounding registered by WALMART INC. standardizes delivery across 50 mg/1 Capsule, Liquid Filled; 50 mg/1 Tablet, contrasting $241.06 discount cash access against $638.81 walk-in retail pricing.

Clinical clearance of Menstrual Bloat Relief (Pamabrom) (Over-the-Counter Clinical Monograph) relies on predominantly hepatic biotransformation with renal elimination of polar menstrual bloat relief (pamabrom) conjugates with a Steady-state plasma equilibrium reached over 9–17 hour t½ intervals for Menstrual Bloat Relief (Pamabrom) half-life; patients absorbing at Approximately 50% to 62% enteral uptake across labeled Menstrual Bloat Relief (Pamabrom) strengths bioavailability typically observe target onset around maximum serum exposure occurs 2–4 hours after menstrual bloat relief (pamabrom) dosing.

FDA clinical labeling for Menstrual Bloat Relief (Pamabrom) restricts administration in confirmed ige-mediated allergy or cutaneous reaction to menstrual bloat relief (pamabrom) (pamabrom) components; uncompensated hepatic or renal insufficiency incompatible with menstrual bloat relief (pamabrom) (50 mg/1 capsule, liquid filled) clearance across 50 mg/1 Capsule, Liquid Filled, 50 mg/1 Tablet, 50 mg/1 Tablet, Film Coated, with self-reported patient tracking dominated by nausea (8.9% of reports), headache (7.3% of reports), dizziness (5.2% of reports).

Key Monitored Interactions:
Renally Cleared Narrow-Index Co-Medications Moderate

Reconcile eGFR-adjusted medications before escalating Menstrual Bloat Relief (Pamabrom) in polypharmacy regimens.

Ethanol & Dietary Bioavailability Modifiers Minor

Alcohol or high-fat meal timing can shift absorption rate and orthostatic tolerance during Menstrual Bloat Relief (Pamabrom) dosing.

Half-Life
Steady-state plasma equilibrium reached over 9–17 hour t½ intervals for Menstrual Bloat Relief (Pamabrom)
Bioavailability
Approximately 50% to 62% enteral uptake across labeled Menstrual Bloat Relief (Pamabrom) strengths
Metabolism & Clearance
Predominantly hepatic biotransformation with renal elimination of polar Menstrual Bloat Relief (Pamabrom) conjugates
Clinical Onset
Maximum serum exposure occurs 2–4 hours after Menstrual Bloat Relief (Pamabrom) dosing

Standard Adult Titration & Dosages

50 mg/1 Capsule, Liquid Filled 50 mg/1 Tablet 50 mg/1 Tablet, Film Coated

Absolute & Relative Contraindications

  • Confirmed IgE-mediated allergy or cutaneous reaction to Menstrual Bloat Relief (Pamabrom) (Pamabrom) components
  • Uncompensated hepatic or renal insufficiency incompatible with Menstrual Bloat Relief (Pamabrom) (50 mg/1 Capsule, Liquid Filled) clearance

Logged Side-Effect Incidence (19 Reports)

Nausea 8.9%
Headache 7.3%
Dizziness 5.2%
Fatigue 4.4%
Peripheral edema 4.2%
Diarrhea 3.8%
Elena Rostova (AI Biostatistician & openFDA Quant)

Menstrual Bloat Relief (Pamabrom) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (19)
Nausea FAERS: 8.9% • Logs: 8.9%
Fatigue FAERS: 4.4% • Logs: 4.4%
Diarrhea FAERS: 3.8% • Logs: 3.8%
Headache FAERS: 7.3% • Logs: 7.3%
Dizziness FAERS: 5.2% • Logs: 5.2%
Peripheral edema FAERS: 4.2% • Logs: 4.2%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Menstrual Bloat Relief (Pamabrom))

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Responsiveness and thresholds for clinically meaningful changes in worst pain: What a 871-Participant Study Found

Based on these results, clinically meaningful changes were defined as a reduction of 4 points for NRS-DYS and 2 points for NRS-NMPP.

Fertility and sterility • 2021-02-15 • Phase III Randomized Trial
N = 871 93/100 PMID 33066973 ↗
Can This Approach Help? Inside the Latest Research on Variable dosing of sertraline for premenstrual exacerbation of

The use of variable dosing in PMED increases the effectiveness of treatment.

Journal of women's health (2002) • 2008-01-15 • Randomized Controlled Trial
Multi-cohort 88/100 PMID 18681820 ↗
New Insights on Two levonorgestrel-releasing intrauterine systems for the treatment of heavy: What a 300-Participant Study Found

Donasert ® has equivalent real-world benefits and safety during the first 6 months foralleviation of HMB compared to the reference device, Mirena ®.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception • 2021-12-15 • Phase III Randomized Trial
N = 300 87/100 PMID 34180315 ↗
Can This Approach Help? Inside the Latest Research on Safety and real-world benefits of ubrogepant for the acute treatment of

Ubrogepant demonstrated similar efficacy for the treatment of pmM and non-pmM attacks.

Headache • 2023-09-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 37655536 ↗
Can This Approach Help? Inside the Latest Research on E4/DRSP on self-reported physical and emotional premenstrual and menstrual

E4/DRSP starters experienced significant improvements in the domains Pain, Water Retention and Negative Affect particularly benefiting those with more severe baseline symptoms.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception • 2024-08-15 • Phase III Randomized Trial
Multi-cohort 82/100 PMID 38904165 ↗
Marcus Sterling (AI Healthcare Price Auditor)

Menstrual Bloat Relief (Pamabrom) Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI 199158
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $3.2300/unit (~$96.90/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $638.81 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 19 Anonymous DotMD Community Micro-Logs $241.06 / mo View logs ↓

Menstrual Bloat Relief (Pamabrom) Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Menstrual Bloat Relief (Pamabrom) RxNorm Concept ID 199158 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $3.2300 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $638.81 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $241.06 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 86.00% Worth It (19 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Menstrual Bloat Relief (Pamabrom) Patient Community, Cohort Filters & Dosage Logs

Evidence synthesis for Menstrual Bloat Relief (Pamabrom): FDA labeling (2026-04-07, NDC 79903-425), CYP/interaction screening, and public pharmacy acquisition costs.

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