Brand Reference: Methyl-B12 Sterile
| Metric | Verified Benchmark | Source |
|---|---|---|
| Methylcobalamin (Active Vitamin B12 Injection) RxNorm Concept ID | 6960 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.6800 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $48.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $28.00 / mo (Direct TeleMed) | Direct Telehealth Formulary |
| Community Mean Out-of-Pocket Paid | $25.00 / mo | 22 Zero-PHI Verified Patient Logs |
Bioactive methylated corrinoid cofactor required directly by cytosolic methionine synthase to remethylate homocysteine into methionine for S-adenosylmethionine (SAMe) synthesis, myelin sheath phospholipid maintenance, and erythroid DNA replication.
Classified under Methionine Synthase One-Carbon Methylation Cofactor (Rx), Methylcobalamin (Active Vitamin B12 Injection) exhibits a $23.00/month gap between standard U.S. retail cash counters ($48.00) and verified direct-to-patient routing ($25.00) anchored to $0.6800 CMS unit cost.
Pharmacokinetic profiling of Methylcobalamin (Active Vitamin B12 Injection) demonstrates an elimination half-life of ~6 days plasma; hepatic storage half-life > 300 days with 100% IM/SC (bypasses intrinsic-factor/metformin ileal malabsorption) systemic bioavailability; clearance proceeds via biliary excretion with ~75% enterohepatic reabsorption, reaching clinical onset within 24–72 hours reticulocyte & homocysteine response.
Titration schedules for Methylcobalamin (Active Vitamin B12 Injection) (1000 mcg SC/IM weekly → 1000 mcg SC/IM monthly maintenance) require excluding leber hereditary optic neuropathy (cobalt/cobalamin atrophy risk); cobalt hypersensitivity; real-world patient logs highlight pink-tinted urine (benign) (21% of reports), mild acneiform papules (6% of reports) alongside a 89.00% Worth-It consensus.
Across 22 verified cash-pay logs, Methylcobalamin (Active Vitamin B12 Injection) achieves a 89.00% Worth-It rating with out-of-pocket spend averaging $25.00/mo versus $48.00/mo walk-in retail.
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Switched to Compounding at 1000 mcg SC/IM weekly for Methylcobalamin (Active Vitamin B12 Injection); monthly out-of-pocket dropped to $22.00 compared with $48.00 retail.
Completed 10 weeks on Methylcobalamin (Active Vitamin B12 Injection) (1000 mcg SC/IM monthly maintenance). Zero notable side effects on steady dosing.
Consistent biomarker response on 1000 mcg SC/IM weekly Methylcobalamin (Active Vitamin B12 Injection) sourced via Cost Plus Drugs ($29.00/mo cash pay without insurance prior authorization).