Brand Reference: Prometrium
| Metric | Verified Benchmark | Source |
|---|---|---|
| Micronized Progesterone USP (Bioidentical) RxNorm Concept ID | 8727 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.2850 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $74.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $10.80 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $14.00 / mo | 35 Zero-PHI Verified Patient Logs |
Particle-micronized progesterone suspended in oil that induces secretory endometrial differentiation (preventing estrogenic hyperplasia) while 5-alpha-reducing into allopregnanolone—positively modulating neuronal GABA-A receptors to deepen slow-wave sleep without synthetic progestin breast/lipid risk.
Across 35 community cost disclosures for Micronized Progesterone USP (Bioidentical) (Prometrium), cash buyers routing around $74.00 retail markups capture a 85% discount ($10.80/mo benchmark vs $0.2850 NADAC acquisition).
Following administration (100 mg PO QHS continuous), Micronized Progesterone USP (Bioidentical) achieves ~10%–15% oral (doubled when taken with evening meal) bioavailability and 45–90 minutes bedtime somnolence; cyclic endometrial protection onset, governed by a 16–18 hours terminal half-life through hepatic 5-alpha/5-beta reductase to pregnanediol and neuroactive allopregnanolone.
Before initiating Micronized Progesterone USP (Bioidentical) at 100 mg PO QHS continuous, clinical safety checklists rule out severe peanut oil allergy (commercial softgels contain arachis oil); active thromboembolic stroke/dvt; breast carcinoma. Logged tolerability patterns center on evening drowsiness (beneficial qhs) (28% of reports), morning grogginess at 200 mg (12% of reports), bloating (9% of reports).
Across 35 verified cash-pay logs, Micronized Progesterone USP (Bioidentical) achieves a 93.70% Worth-It rating with out-of-pocket spend averaging $14.00/mo versus $74.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 100 mg PO QHS continuous for Micronized Progesterone USP (Bioidentical); monthly out-of-pocket dropped to $9.50 compared with $74.00 retail.
Completed 10 weeks on Micronized Progesterone USP (Bioidentical) (200 mg PO QHS continuous or days 15–28 cyclic). Zero notable side effects on steady dosing.
Consistent biomarker response on 100 mg PO QHS continuous Micronized Progesterone USP (Bioidentical) sourced via Local Pharmacy ($12.53/mo cash pay without insurance prior authorization).