Brand Reference: Singulair
| Metric | Verified Benchmark | Source |
|---|---|---|
| Montelukast Sodium RxNorm Concept ID | 88249 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.0410 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $32.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $5.20 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $6.40 / mo | 26 Zero-PHI Verified Patient Logs |
Binds bronchial and nasal mucosal CysLT1 receptors with high selectivity to block leukotriene D4-mediated airway edema, eosinophil recruitment, and exercise-induced bronchoconstriction.
CMS National Average Drug Acquisition Cost (NADAC) tracking places Montelukast Sodium (Singulair, RxCUI 88249) at $0.0410 per unit, whereas walk-in chain pharmacies bill cash patients an average of $32.00 monthly—creating a 84% ($26.80/mo) wholesale arbitrage spread down to $5.20.
Systemic exposure to Montelukast Sodium reflects 64% oral absorption kinetics and hepatic cyp2c8 (major), cyp3a4, and cyp2c9; 86% biliary fecal clearance, sustaining receptor engagement across a 2.7–5.5 hours half-life window (2–4 hours airway leukotriene blockade response profile).
Dosing protocols (10 mg PO once daily in evening) balance efficacy (78.60% patient satisfaction across 26 logs) against vivid dreams / sleep disturbance (18% of reports), headache (8% of reports), with strict avoidance in prior montelukast neuropsychiatric mood/sleep disturbance.
Across 26 verified cash-pay logs, Montelukast Sodium achieves a 78.60% Worth-It rating with out-of-pocket spend averaging $6.40/mo versus $32.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 10 mg PO once daily in evening for Montelukast Sodium; monthly out-of-pocket dropped to $4.58 compared with $32.00 retail.
Completed 10 weeks on Montelukast Sodium (10 mg PO once daily in evening). Zero notable side effects on steady dosing.
Consistent biomarker response on 10 mg PO once daily in evening Montelukast Sodium sourced via Local Pharmacy ($6.03/mo cash pay without insurance prior authorization).