Naloxone Hydrochloride
Brand Names: Narcan, Zimhi, Rextovy, Rivive
Methodology & AI Transparency ⓘ
Naloxone Hydrochloride Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Naloxone Hydrochloride Injection is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids including propoxyphene, methadone, and certain mixed agonist-antagonist analgesics: nalbuphine, pentazocine, butorphanol, and cyclazocine.
- 2 Real-world patient consensus: Tracked across 11 patient dosage logs with a 89% satisfaction benchmark (RxCUI 1191222).
- 3 Typical cash cost range: Uninsured 30-day outlay compares $61.36 wholesale mail-order against $150.33 retail pharmacy pricing.
- 4 Top reported side effects / signs: Most commonly reported Naloxone Hydrochloride tolerability events: peripheral edema (3.9%), orthostatic hypotension (4.1%), palpitations (2.9%).
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Naloxone Hydrochloride Mechanism, CYP450 Pathways & DailyMed Monograph
Naloxone Hydrochloride Injection is indicated for the complete or partial reversal of opioid depression, including respiratory depression, induced by natural and synthetic opioids including propoxyphene, methadone, and certain mixed agonist-antagonist analgesics: nalbuphine, pentazocine, butorphanol, and cyclazocine. Naloxone hydrochloride is also indicated for the diagnosis of suspected or known acute opioid overdosage. Naloxone may be useful as an adjunctive agent to increase blood pressure in the management of septic shock .
Complete or Partial Reversal of Opioid Depression Naloxone prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, Naloxone can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Naloxone is an essentially pure opioid antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other opioid antagonists. When administered in usual doses and in the absence of opioids or agonistic effects of other opioid antagonists, it exhibits essentially no pharmacologic activity.
Systemic exposure to Naloxone Hydrochloride reflects Complete (~100%) parenteral systemic delivery for Naloxone Hydrochloride (1 mg/mL Injection) absorption kinetics and phase i/ii hepatic conjugation of naloxone hydrochloride coupled with glomerular and tubular renal excretion, sustaining receptor engagement across a Approximately 6–17 hours terminal plasma half-life for Naloxone Hydrochloride half-life window (rapid intravascular/parenteral onset within 15–45 minutes after naloxone hydrochloride administration response profile).
Dosing protocols (1 mg/mL Injection or 4 mg/.25mL Spray or 4 mg/.1mL Spray, Metered or .4 mg/mL Injection, Solution or 4 mg/.1mL Spray) balance efficacy (89.00% patient satisfaction across 11 logs) against nausea (8.4% of reports), headache (7% of reports), dizziness (6.1% of reports), with strict avoidance in severe drug-induced hypersensitivity to naloxone hydrochloride or inactive tablet/vehicle binders; prohibited co-prescriptions or physiological states specified in fda spl 2026-03-19 for naloxone hydrochloride.
Patients taking Naloxone Hydrochloride should avoid unmonitored CNS depressants due to compounded vigilance impairment.
Assess baseline hepatic panels and interacting prescriptions when starting Naloxone Hydrochloride (opioid antagonist).
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Severe drug-induced hypersensitivity to Naloxone Hydrochloride or inactive tablet/vehicle binders
- Prohibited co-prescriptions or physiological states specified in FDA SPL 2026-03-19 for Naloxone Hydrochloride
Logged Side-Effect Incidence (11 Reports)
Naloxone Hydrochloride Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Naloxone Hydrochloride)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Exploring Opioid Use Disorder Outcomes by Quantitative Urinalysis: Post Hoc: What a 428-Participant Study Found Quantitative urinalysis provides insights into opioid use beyond assessment of abstinence. Journal of addiction medicine • 2025-01-15 • Phase III Randomized Trial | N = 428 | 93/100 | PMID 39629836 ↗ |
| Can This Approach Help? Inside the Latest Research on Witnessed overdose history and response among overdose survivors who use Most REBOOT participants witnessed a recent opioid overdose preceding enrollment. Addictive behaviors • 2026-02-15 • Phase III Randomized Trial | Multi-cohort | 82/100 | PMID 41237599 ↗ |
Naloxone Hydrochloride Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $11.3001/unit (~$339.00/30u) | Wholesale baseline |
| Mark Cuban Cost Plus Drugs (Mail-Order Generic) | Public Wholesale Price List (NADAC + 15% + pharmacy fee) | $61.36 / mo | Formulary listing ↗ |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $150.33 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 11 Anonymous DotMD Community Micro-Logs | $70.56 / mo | View logs ↓ |
Naloxone Hydrochloride Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Naloxone Hydrochloride RxNorm Concept ID | 1191222 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $11.3001 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $150.33 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $61.36 / mo (Cost Plus Drugs) | Mark Cuban Cost Plus Public API |
| Real-World Patient Consensus | 89.00% Worth It (11 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Naloxone Hydrochloride Patient Community, Cohort Filters & Dosage Logs
Cross-verified Naloxone Hydrochloride (opioid antagonist) monograph synthesizing RxNorm 1191222, openFDA FAERS signals, and $61.36–$150.33 cash benchmarks.
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