Brand Reference: Urocit-K
| Metric | Verified Benchmark | Source |
|---|---|---|
| Potassium Citrate Wax-Matrix ER (Urocit-K) RxNorm Concept ID | 8591 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.2800 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $86.00 / mo | CMS NADAC + U.S. Retail Markup Index |
| Mark Cuban Cost Plus Wholesale Price | $12.40 / mo | Cost Plus Drugs Wholesale Feed |
| Community Mean Out-of-Pocket Paid | $15.00 / mo | 16 Zero-PHI Verified Patient Logs |
Hepatically oxidized to bicarbonate (3 mEq alkali per mmol citrate), raising urinary pH to 6.5–7.0 to dissolve uric-acid stones while boosting renal tubular citrate excretion—forming soluble calcium-citrate complexes that prevent calcium-oxalate crystallization on ketogenic or topiramate regimens.
Classified under Urinary Citrate Chelator & Systemic Alkali Buffer (Rx), Potassium Citrate Wax-Matrix ER (Urocit-K) exhibits a $73.60/month gap between standard U.S. retail cash counters ($86.00) and verified direct-to-patient routing ($12.40) anchored to $0.2800 CMS unit cost.
Pharmacokinetic profiling of Potassium Citrate Wax-Matrix ER (Urocit-K) demonstrates an elimination half-life of 4–6 hours wax-matrix release with > 90% gastrointestinal absorption systemic bioavailability; clearance proceeds via complete tricarboxylic acid cycle oxidation to bicarbonate (<5% excreted un-metabolized as direct citrate), reaching clinical onset within 24 hours urinary ph & 24h-citrate rise.
Titration schedules for Potassium Citrate Wax-Matrix ER (Urocit-K) (10 mEq (1080 mg) PO BID–TID with meals → 15 mEq PO BID with meals) require excluding hyperkalemia or concurrent spironolactone/eplerenone without k+ labs; delayed gastric emptying / gi stricture; active proteus urease uti; real-world patient logs highlight wax-matrix ghost shell in stool (21% of reports), mild gastric irritation if fasting (13% of reports) alongside a 88.20% Worth-It consensus.
Across 16 verified cash-pay logs, Potassium Citrate Wax-Matrix ER (Urocit-K) achieves a 88.20% Worth-It rating with out-of-pocket spend averaging $15.00/mo versus $86.00/mo walk-in retail.
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Switched to Cost Plus Drugs at 10 mEq (1080 mg) PO BID–TID with meals for Potassium Citrate Wax-Matrix ER (Urocit-K); monthly out-of-pocket dropped to $10.91 compared with $86.00 retail.
Completed 10 weeks on Potassium Citrate Wax-Matrix ER (Urocit-K) (15 mEq PO BID with meals). Zero notable side effects on steady dosing.
Consistent biomarker response on 10 mEq (1080 mg) PO BID–TID with meals Potassium Citrate Wax-Matrix ER (Urocit-K) sourced via Local Pharmacy ($14.38/mo cash pay without insurance prior authorization).