Progesterone

Indications and usage: Progesterone capsules are indicated for use in the prevention of endometrial hyperplasia in nonhysterectomized postmenopausal women who are receiving conjugated estrogens tablets. They are also indicated for use in secondary amenorrhea.

CLINICAL PHARMACOLOGY Progesterone capsules are an oral dosage form of micronized progesterone which is chemically identical to progesterone of ovarian origin. The oral bioavailability of progesterone is increased through micronization. Pharmacokinetics A. Absorption After oral administration of progesterone as a micronized soft-gelatin capsule formulation, maximum serum concentrations were attained within 3 hours. The absolute bioavailability of micronized progesterone is not known.

With Biphasic clearance with 11–15 hr terminal t½ under Progesterone maintenance residence kinetics and Systemic oral bioavailability of roughly 47%–59% following first-pass transit bioavailability, Progesterone undergoes hepatic enzymatic processing and renal clearance proportional to creatinine clearance (progesterone) and establishes therapeutic activity over initial pharmacodynamic onset within 1–3 hrs (peak cmax) for progesterone.

Standard adult regimens span 100 mg/1 Capsule, 200 mg/1 Capsule, 6 [hp_X]/mL Liquid, 100 mg/1 Insert, 45 mg/1.125g Gel. Prescribers screen specifically against progesterone capsules contain peanut oil and should never be used by patients allergic to peanuts.; undiagnosed abnormal genital bleeding., while community micro-logs most frequently note nausea (8.5% of reports), headache (8.2% of reports), dizziness (6.7% of reports).