Prozac (Fluoxetine Hydrochloride)
Brand Names: Prozac
Methodology & AI Transparency ⓘ
Prozac (Fluoxetine Hydrochloride) Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Within the Serotonin Reuptake Inhibitor category, Prozac provides branded delivery of active moiety Fluoxetine Hydrochloride (cross-referenced at /meds/fluoxetine-hcl) (registered by Dista Products Company; NDC 0777-3104, 0777-3105).
- 2 Real-world patient consensus: Registered under RxNorm 104849 and SPL 2026-01-08, pairing Prozac packaging with active ingredient Fluoxetine Hydrochloride.
- 3 Typical cash cost range: 30-day cash pricing ranges from $5.37 on Cost Plus Drugs to $34.50 walk-in retail (NADAC $13.5891/unit).
- 4 Top reported side effects / signs: Leading openFDA/SPL adverse events for Prozac (Fluoxetine Hydrochloride): insomnia (6.3%), vomiting (5.6%), cutaneous rash (3.9%).
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Prozac (Fluoxetine Hydrochloride) Mechanism, CYP450 Pathways & DailyMed Monograph
Within the Serotonin Reuptake Inhibitor category, Prozac provides branded delivery of active moiety Fluoxetine Hydrochloride (cross-referenced at /meds/fluoxetine-hcl) (registered by Dista Products Company; NDC 0777-3104, 0777-3105). Characterized by 10 mg/1 Capsule; 20 mg/1 Capsule under 2026-01-08 SPL documentation, Prozac targets 1 Indications and usage prozac: ® is indicated for the treatment of: Acute and maintenance treatment of Major Depressive.
Through its Fluoxetine Hydrochloride active moiety, Prozac exerts serotonin reuptake inhibitor activity involving CYP2D6 clearance pathways. Registered under NDC 0777-3104, 0777-3105 (registered by Dista Products Company; effective 2026-01-08), the 10 mg/1 Capsule; 20 mg/1 Capsule presentation ensures reproducible pharmacokinetic release profiles documented in federal RxNorm (104849) and CMS NADAC ($13.5891/unit) ledgers.
Pharmacokinetic profiling of Prozac (Fluoxetine Hydrochloride) demonstrates an elimination half-life of Approximately 6–16 hours terminal plasma half-life for Prozac (Fluoxetine Hydrochloride) with Estimated 57%–69% oral systemic absorption for Prozac (Fluoxetine Hydrochloride) systemic bioavailability; clearance proceeds via hepatic oxidation via cyp2d6 followed by renal and biliary excretion of prozac (fluoxetine hydrochloride) metabolites, reaching clinical onset within peak plasma concentration (tmax) reached 1–2 hours post-dose for prozac (fluoxetine hydrochloride).
Titration schedules for Prozac (Fluoxetine Hydrochloride) (10 mg/1 Capsule → 20 mg/1 Capsule → 40 mg/1 Capsule → 10mg Capsule) require excluding severe drug-induced hypersensitivity to fluoxetine hydrochloride or inactive tablet/vehicle binders; prohibited co-prescriptions or physiological states specified in fda spl 2026-01-08 for prozac (fluoxetine hydrochloride); real-world patient logs highlight nausea (8.8% of reports), headache (7.2% of reports), insomnia (6.3% of reports) alongside a 86.00% Worth-It consensus.
Allow at least two weeks between MAOI discontinuation and Prozac (Fluoxetine Hydrochloride) dosing to prevent neurotransmitter toxicity.
Review concurrent CYP2D6 substrates and inhibitors when titrating Prozac (Fluoxetine Hydrochloride) maintenance doses.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Severe drug-induced hypersensitivity to Fluoxetine Hydrochloride or inactive tablet/vehicle binders
- Prohibited co-prescriptions or physiological states specified in FDA SPL 2026-01-08 for Prozac (Fluoxetine Hydrochloride)
Logged Side-Effect Incidence (22 Reports)
Prozac (Fluoxetine Hydrochloride) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Prozac (Fluoxetine Hydrochloride))
Human clinical trial evidence for Prozac (Fluoxetine Hydrochloride) is indexed directly from the U.S. National Library of Medicine NCBI PubMed database. Explore recent randomized trials in the PubMed Research Pulse .
Prozac (Fluoxetine Hydrochloride) Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $13.5891/unit (~$407.67/30u) | Wholesale baseline |
| Mark Cuban Cost Plus Drugs (Mail-Order Generic) | Public Wholesale Price List (NADAC + 15% + pharmacy fee) | $5.37 / mo | Formulary listing ↗ |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.50 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 22 Anonymous DotMD Community Micro-Logs | $7.50 / mo | View logs ↓ |
Prozac (Fluoxetine Hydrochloride) Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Prozac (Fluoxetine Hydrochloride) RxNorm Concept ID | 104849 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $13.5891 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.50 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $5.37 / mo (Cost Plus Drugs) | Mark Cuban Cost Plus Public API |
| Real-World Patient Consensus | 86.00% Worth It (22 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Prozac (Fluoxetine Hydrochloride) Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Prozac (Fluoxetine Hydrochloride) integrating DailyMed SPL (2026-01-08), CMS NADAC ($13.5891/unit), and 22 Zero-PHI patient logs.
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