Silver Sulfadiazine
Brand Names: Silvadene, Ssd Cream, Thermazene, Ssd, SSD
Methodology & AI Transparency ⓘ
Silver Sulfadiazine Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Indications and usage: Silver sulfadiazine cream, USP 1% is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns.
- 2 Real-world patient consensus: Tracked across 6 patient dosage logs with a 86% satisfaction benchmark (RxCUI 106351).
- 3 Typical cash cost range: 30-day cash pricing ranges from $12.60 on Cost Plus Drugs to $34.60 walk-in retail (NADAC $0.1197/unit).
- 4 Top reported side effects / signs: Most commonly reported Silver Sulfadiazine tolerability events: diarrhea (8.8%), nausea (8.5%), headache (5.5%).
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Silver Sulfadiazine Mechanism, CYP450 Pathways & DailyMed Monograph
Indications and usage: Silver sulfadiazine cream, USP 1% is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns.
CLINICAL PHARMACOLOGY Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from in vitro testing are listed below. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine.
With Localized tissue retention for Silver Sulfadiazine with minimal systemic plasma half-life residence kinetics and < 5% transdermal or mucosal systemic uptake from Silver Sulfadiazine bioavailability, Silver Sulfadiazine undergoes local esterase/enzymatic cleavage of silver sulfadiazine with minimal hepatic cytochrome burden and establishes therapeutic activity over initial local symptom modulation in 30–90 minutes; full tissue response over 1–3 weeks (silver sulfadiazine).
Standard adult regimens span 10 mg/g Cream, 10 g/1000g Cream, 1% Tube of Cream, 1% Jar of Cream. Prescribers screen specifically against contraindications silver sulfadiazine cream, usp 1% is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation.; severe drug-induced hypersensitivity to silver sulfadiazine or inactive tablet/vehicle binders, while community micro-logs most frequently note diarrhea (8.8% of reports), nausea (8.5% of reports), headache (5.5% of reports).
Assess baseline hepatic panels and interacting prescriptions when starting Silver Sulfadiazine (sulfonamide antibacterial).
Alcohol or high-fat meal timing can shift absorption rate and orthostatic tolerance during Silver Sulfadiazine dosing.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- CONTRAINDICATIONS Silver sulfadiazine cream, USP 1% is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation.
- Severe drug-induced hypersensitivity to Silver Sulfadiazine or inactive tablet/vehicle binders
Logged Side-Effect Incidence (6 Reports)
Silver Sulfadiazine Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Silver Sulfadiazine)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| New Insights on Controlled Trial of Silver Diamine Fluoride Application: What a 665-Participant Study Found The trial found an increase in the proportion of arrested lesions with increasing SDF application time, although the rate of the proportion of arrested lesions decreased over application time. Journal of dental research • 2025-12-15 • Phase III Randomized Trial | N = 665 | 93/100 | PMID 40583169 ↗ |
| Can This Approach Help? Inside the Latest Research on Hypericum and neem oil for dehisced post-surgical wounds: a randomised, This randomised controlled trial confirmed the efficacy of 1PWD, an investigational product, in the management of surgical dehiscence with critical colonisation or infection, with the added benefit of significant pain... Journal of wound care • 2022-06-02 • Phase III Randomized Trial | N = 99 | 82/100 | PMID 35678785 ↗ |
Silver Sulfadiazine Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $0.1197/unit (~$3.59/30u) | Wholesale baseline |
| Mark Cuban Cost Plus Drugs (Mail-Order Generic) | Public Wholesale Price List (NADAC + 15% + pharmacy fee) | $12.60 / mo | Formulary listing ↗ |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $34.60 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 6 Anonymous DotMD Community Micro-Logs | $14.49 / mo | View logs ↓ |
Silver Sulfadiazine Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Silver Sulfadiazine RxNorm Concept ID | 106351 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $0.1197 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $34.60 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $12.60 / mo (Cost Plus Drugs) | Mark Cuban Cost Plus Public API |
| Real-World Patient Consensus | 86.00% Worth It (6 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Silver Sulfadiazine Patient Community, Cohort Filters & Dosage Logs
Federal clinical ledger for Silver Sulfadiazine integrating DailyMed SPL (2026-07-13), CMS NADAC ($0.1197/unit), and 6 Zero-PHI patient logs.
Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.
Filter Silver Sulfadiazine community threads and patient logs by age, biological sex, dosage, and treatment duration.