Sofosbuvir
Brand Names: Sovaldi
Methodology & AI Transparency ⓘ
Sofosbuvir Key Takeaways
Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level
- 1 What it does: Within prescription hepatitis c virus nucleotide analog ns5b polymerase inhibitor care, Sofosbuvir (61958-1501, 61958-1505; manufactured/labeled by Gilead Sciences, Inc.) offers oral-route delivery via 400 mg/1 Tablet, Film Coated and 200 mg/1 Pellet with structured clinical follow-up.
- 2 Real-world patient consensus: Zero-PHI community consensus: 77% favorable across 12 logged regimens (Sovaldi).
- 3 Typical cash cost range: Dispensing cost comparison spans $185.00 mail/discount cash up to $453.25 uninsured retail (federal NADAC $278.3091).
- 4 Top reported side effects / signs: Most commonly reported Sofosbuvir tolerability events: nausea (7.7%), headache (7.8%), dizziness (5.4%).
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Sofosbuvir Mechanism, CYP450 Pathways & DailyMed Monograph
Within prescription hepatitis c virus nucleotide analog ns5b polymerase inhibitor care, Sofosbuvir (61958-1501, 61958-1505; manufactured/labeled by Gilead Sciences, Inc.) offers oral-route delivery via 400 mg/1 Tablet, Film Coated and 200 mg/1 Pellet with structured clinical follow-up.
In oral-route clinical dosing (400 mg/1 Tablet, Film Coated and 200 mg/1 Pellet), Sofosbuvir (manufactured/labeled by Gilead Sciences, Inc.; 61958-1501, 61958-1505) executes hepatitis c virus nucleotide analog ns5b polymerase inhibitor molecular modulation paired with routine metabolic and excretory disposition.
Pharmacokinetic profiling of Sofosbuvir demonstrates an elimination half-life of Steady-state plasma equilibrium reached over 6–19 hour t½ intervals for Sofosbuvir with Approximately 69% to 81% enteral uptake across labeled Sofosbuvir strengths systemic bioavailability; clearance proceeds via predominantly hepatic biotransformation with renal elimination of polar sofosbuvir conjugates, reaching clinical onset within maximum serum exposure occurs 2–3 hours after sofosbuvir dosing.
Titration schedules for Sofosbuvir (400 mg/1 Tablet, Film Coated → 200 mg/1 Pellet → 150 mg/1 Pellet → 200 mg/1 Tablet, Film Coated) require excluding contraindicated in patients with prior serious allergic response to sofosbuvir (ndc 61958-1501); severe baseline organ impairment where sofosbuvir accumulation exceeds safe therapeutic margins; real-world patient logs highlight headache (7.8% of reports), nausea (7.7% of reports), dizziness (5.4% of reports) alongside a 77.00% Worth-It consensus.
Reconcile eGFR-adjusted medications before escalating Sofosbuvir in polypharmacy regimens.
Shifts in intragastric pH can modestly influence dissolution kinetics of oral Sofosbuvir dosage forms.
Standard Adult Titration & Dosages
Absolute & Relative Contraindications
- Contraindicated in patients with prior serious allergic response to Sofosbuvir (NDC 61958-1501)
- Severe baseline organ impairment where Sofosbuvir accumulation exceeds safe therapeutic margins
Logged Side-Effect Incidence (12 Reports)
Sofosbuvir Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs
Peer-Reviewed Human Clinical Trials & Meta-Analyses (Sofosbuvir)
| Study & Plain-English Finding | Sample (N) | Rigor | Primary Source |
|---|---|---|---|
| Can This Approach Help? Inside the Latest Research on Benefits and safety of sofosbuvir plus daclatasvir or ravidasvir in patients with On the other hand, adding SOF-RDV to SOC did not show significant improvements in endpoints. Journal of medical virology • 2021-12-15 • Phase III Randomized Trial | Multi-cohort | 82/100 | PMID 34379337 ↗ |
Sofosbuvir Public Price Transparency Ledger
| Dispensing Channel / Benchmark | Verification Source | Reference Cost | Details |
|---|---|---|---|
| Pharmacy Acquisition Cost (CMS NADAC) | CMS Medicaid NADAC Weekly National Survey | $278.3091/unit (~$8349.27/30u) | Wholesale baseline |
| Average U.S. Walk-In Retail Cash Price | Chain Pharmacy Uninsured Cash Index | $453.25 / mo | Before coupon/insurance |
| Patient-Logged Out-of-Pocket Average | 12 Anonymous DotMD Community Micro-Logs | $185.00 / mo | View logs ↓ |
Sofosbuvir Federal Verification & Benchmark Summary
| Metric | Verified Benchmark | Source |
|---|---|---|
| Sofosbuvir RxNorm Concept ID | RXN-619581501-2393 | U.S. National Library of Medicine (RxNorm) |
| CMS NADAC Pharmacy Acquisition Unit Cost | $278.3091 / unit | CMS Medicaid NADAC Weekly Feed |
| Walk-In Chain Pharmacy Cash Average | $453.25 / mo | U.S. Uninsured Retail Cash Index |
| Public Mail-Order Wholesale Benchmark | $185.00 / mo (Patient Mean) | Public Cash Reference |
| Real-World Patient Consensus | 77.00% Worth It (12 anonymous logs) | DotMD Zero-PHI Patient Ledger |
Sofosbuvir Patient Community, Cohort Filters & Dosage Logs
Cross-verified Sofosbuvir (hepatitis c virus nucleotide analog ns5b polymerase inhibitor) monograph synthesizing RxNorm RXN-619581501-2393, openFDA FAERS signals, and $185.00–$453.25 cash benchmarks.
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Filter Sofosbuvir community threads and patient logs by age, biological sex, dosage, and treatment duration.