dotMD.com
Muscle Relaxant • Prescription (Rx)

Soma (Carisoprodol)

Brand Names: Soma

Audited by the DotMD AI Specialist Council • FDA DailyMed SPL: 2026-03-17 • RxNorm RxCUI RXN-B00372001 • 9 Linked .gov / PubMed Citations • Governance: Dr. Hannah Lindqvist, MD, PhD (NPI #1457952647)
Methodology & AI Transparency ⓘ
Data on this page is deterministically ingested from official U.S. federal datasets (NIH RxNorm, MedlinePlus, FDA DailyMed SPL, openFDA FAERS, NCBI PubMed, and CMS Medicaid NADAC / Medicare Part B) and translated into plain English by DotMD's 5 specialized AI research agents under NPI-verified clinical governance.
At a Glance • Plain-English Clinical Summary

Soma (Carisoprodol) Key Takeaways

Translated by Sarah Jenkins (AI RN Plain-English Translator) at a 7th-grade reading level

93%
Patient “Worth It” (22)
$640.00
Lowest Cash / Mo
Transparent AI Research Council • Grounded on NIH / FDA / PubMed Data

Ask our AI Specialists anything about Soma (Carisoprodol)

3 of 3 Free Questions Remaining
Dr. Vance (AI Pharmacology & Interaction Agent)

Soma (Carisoprodol) Mechanism, CYP450 Pathways & DailyMed Monograph

RxCUI RXN-B00372001 • NDC 0037-2001

Soma (Carisoprodol) represents a prescription brand-name muscle relaxant entry registered by Viatris Specialty LLC with package codes 0037-2001, 0037-2250. Reviewed against 2026-03-17 FDA SPL standards (350 mg/1 Tablet; 250 mg/1 Tablet), clinical deployment addresses Carisoprodol tablets are indicated for the relief of discomfort associated with acute, painful musculoskeletal conditions.

Soma achieves therapeutic action via Carisoprodol, engaging muscle relaxant physiological pathways with class-characteristic hepatorenal disposition. Manufactured in 350 mg/1 Tablet; 250 mg/1 Tablet (registered by Viatris Specialty LLC, NDC 0037-2001, 0037-2250), pharmacists evaluate FDA Orange Book therapeutic equivalence when comparing branded Soma ($1696.00 retail) with generic Carisoprodol ($640.00 low cash).

Systemic exposure to Soma (Carisoprodol) reflects Oral fraction absorbed ranges from 71% to 83% (Soma (Carisoprodol) 350) absorption kinetics and dual hepatorenal clearance pathway combining glucuronidation and urinary filtration of soma (carisoprodol), sustaining receptor engagement across a Mean elimination half-life of 7 to 12 hours across adult Soma (Carisoprodol) dosing half-life window (oral tmax achieved within 2 to 5 hours following soma (carisoprodol) ingestion response profile).

Dosing protocols (350 mg/1 Tablet or 250 mg/1 Tablet) balance efficacy (93.00% patient satisfaction across 22 logs) against nausea (9.3% of reports), headache (8.9% of reports), dizziness (8.2% of reports), with strict avoidance in contraindicated in patients with prior serious allergic response to soma (carisoprodol) (ndc 0037-2001); severe baseline organ impairment where carisoprodol accumulation exceeds safe therapeutic margins.

Key Monitored Interactions:
CNS Depressants, Sedatives & Opioids Major

Concurrent opioid, benzodiazepine, or alcohol intake amplifies drowsiness and respiratory suppression with Soma (Carisoprodol).

Renally Cleared Narrow-Index Co-Medications Moderate

Reconcile eGFR-adjusted medications before escalating Soma (Carisoprodol) in polypharmacy regimens.

Half-Life
Mean elimination half-life of 7 to 12 hours across adult Soma (Carisoprodol) dosing
Bioavailability
Oral fraction absorbed ranges from 71% to 83% (Soma (Carisoprodol) 350)
Metabolism & Clearance
Dual hepatorenal clearance pathway combining glucuronidation and urinary filtration of Soma (Carisoprodol)
Clinical Onset
Oral Tmax achieved within 2 to 5 hours following Soma (Carisoprodol) ingestion

Standard Adult Titration & Dosages

350 mg/1 Tablet 250 mg/1 Tablet

Absolute & Relative Contraindications

  • Contraindicated in patients with prior serious allergic response to Soma (Carisoprodol) (NDC 0037-2001)
  • Severe baseline organ impairment where Carisoprodol accumulation exceeds safe therapeutic margins

Logged Side-Effect Incidence (22 Reports)

Nausea 9.3%
Headache 8.9%
Dizziness 8.2%
Somnolence 5.3%
Diarrhea 5%
Fatigue 4.7%
Elena Rostova (AI Biostatistician & openFDA Quant)

Soma (Carisoprodol) Real-World Side Effects: openFDA FAERS vs. Patient Micro-Logs

openFDA / Label % Patient Logs (22)
Nausea FAERS: 9.3% • Logs: 9.3%
Fatigue FAERS: 4.7% • Logs: 4.7%
Diarrhea FAERS: 5% • Logs: 5%
Headache FAERS: 8.9% • Logs: 8.9%
Dizziness FAERS: 8.2% • Logs: 8.2%
Somnolence FAERS: 5.3% • Logs: 5.3%
Dr. Lin (AI PubMed Clinical Trial Lead)

Peer-Reviewed Human Clinical Trials & Meta-Analyses (Soma (Carisoprodol))

Browse All PubMed Translations →
Study & Plain-English Finding Sample (N) Rigor Primary Source
New Insights on Somatic complaints in anxious: What a 488-Participant Study Found

Physical symptoms decreased over the course of treatment, and were unrelated to treatment condition.

Child psychiatry and human development • 2014-08-15 • Randomized Controlled Trial
N = 488 93/100 PMID 24129543 ↗
New Insights on Benefits and safety of etifoxine versus alprazolam in generalized anxiety with: What a 260-Participant Study Found

Treatment-emergent AEs were mild and observed in 10% and 7.7% of patients in the Etifoxine and Alprazolam groups, respectively.

Journal of anxiety disorders • 2026-04-15 • Phase III Randomized Trial
N = 260 93/100 PMID 41763071 ↗
Can This Approach Help? Inside the Latest Research on Reduced breakthrough symptom exacerbations in patients with biochemically

In patients with acromegaly biochemically controlled with injected SRLs, switching to once-daily oral paltusotine was associated with stable biochemical control, stable symptom severity, and a significantly reduced frequency...

Pituitary • 2026-07-23 • Phase III Randomized Trial
N = 22 88/100 PMID 42493688 ↗
Can This Approach Help? Inside the Latest Research on A Phase 3 Active-Controlled Trial of Liposomal Bupivacaine via Adductor Canal

Liposomal bupivacaine administered via adductor canal block for total knee arthroplasty was associated with concurrent reductions in pain and opioid consumption compared with bupivacaine during the first 96 hours after surgery.

The Journal of arthroplasty • 2025-10-15 • Phase III Randomized Trial
N = 167 88/100 PMID 40701284 ↗
Can This Approach Help? Inside the Latest Research on Efficacy in Japanese adults with growth hormone deficiency receiving weekly

In Japanese treatment-naïve individuals with AGHD, once-weekly somapacitan demonstrated similar real-world benefits and safety to daily GH after 34 weeks of treatment.

Frontiers in endocrinology • 2025-01-15 • Phase III Randomized Trial
Multi-cohort 88/100 PMID 39991735 ↗
Marcus Sterling (AI Healthcare Price Auditor)

Soma (Carisoprodol) Public Price Transparency Ledger

Neutral federal & cash pharmacy reference • RxCUI RXN-B00372001
Dispensing Channel / Benchmark Verification Source Reference Cost Details
Pharmacy Acquisition Cost (CMS NADAC) CMS Medicaid NADAC Weekly National Survey $11.2975/unit (~$338.92/30u) Wholesale baseline
Average U.S. Walk-In Retail Cash Price Chain Pharmacy Uninsured Cash Index $1696.00 / mo Before coupon/insurance
Patient-Logged Out-of-Pocket Average 22 Anonymous DotMD Community Micro-Logs $640.00 / mo View logs ↓

Soma (Carisoprodol) Federal Verification & Benchmark Summary

Metric Verified Benchmark Source
Soma (Carisoprodol) RxNorm Concept ID RXN-B00372001 U.S. National Library of Medicine (RxNorm)
CMS NADAC Pharmacy Acquisition Unit Cost $11.2975 / unit CMS Medicaid NADAC Weekly Feed
Walk-In Chain Pharmacy Cash Average $1696.00 / mo U.S. Uninsured Retail Cash Index
Public Mail-Order Wholesale Benchmark $640.00 / mo (Patient Mean) Public Cash Reference
Real-World Patient Consensus 93.00% Worth It (22 anonymous logs) DotMD Zero-PHI Patient Ledger
Zero-PHI Patient Community & 15-Second Dosage Logger

Soma (Carisoprodol) Patient Community, Cohort Filters & Dosage Logs

Deterministic Soma (Carisoprodol) reference combining NIH RxNorm (RXN-B00372001), Medicaid NADAC ($11.2975/unit), and anonymous cohort outcomes (93% Worth It).

15-Second Anonymous Micro-Log (Zero-PHI Architecture)

Share your real dosage and monthly out-of-pocket cost—no account, email, or IP stored.

“People Like Me” Cohort Filter (Zero-PHI)

Filter Soma (Carisoprodol) community threads and patient logs by age, biological sex, dosage, and treatment duration.

No threads match this cohort filter yet. Click + Start Anonymous Discussion to ask the community about Soma (Carisoprodol).

Recent Verified Anonymous Patient Micro-Logs (0)